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Pediatric sarcoma
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Children with relapsed central nervous system (CNS tumors), neuroblastoma, sarcomas, and other rare solid tumors face poor outcomes. This prospective clinical trial examined the feasibility of combining genomic and transcriptomic profiling of tumor samples with a molecular tumor board (MTB) approach to make real‑time treatment decisions for children with relapsed/refractory solid tumors.
18p
vicwell
29-02-2024
5
1
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Clear cell sarcoma of the kidney is an uncommon pediatric renal malignant neoplasm that is typically characterized in 2–3-year-olds by aggressive behavior and late relapses. Our literature review revealed fewer than ten previously reported cases of CCSK with inferior vena cava thrombus, with only five in the pediatric age group.
5p
vigamora
23-05-2023
4
2
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There have hardly been any reported cases of children presenting with Kaposi sarcoma as a second malignancy following treatment for acute lymphoblastic leukemia outside a transplant setting.
6p
vigamora
23-05-2023
8
2
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Synovial sarcoma (SS) is one of the reported sarcomas in the pediatric and adult populations. Delay in diagnosis and treatment is common in SS cases. SS may be excised before the correct diagnosis is made
5p
vimariana2711
22-12-2020
12
1
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Identification of new drugs against paediatric sarcomas represents an urgent clinical need that mainly relies on public investments due to the rarity of these diseases. In this paper we evaluated the in vitro and in vivo efficacy of a new maltol derived molecule (maltonis), belonging to the family of molecules named hydroxypyrones.
14p
virose2711
25-09-2020
19
1
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Embryonal Rhabdomyosarcoma (RMS) is a pediatric soft-tissue sarcoma derived from myogenic precursors that is characterized by a good prognosis in patients with localized disease. Conversely, metastatic tumors often relapse, leading to a dismal outcome.
15p
virose2711
25-09-2020
12
1
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Rhabdomyosarcoma (RMS), which can be classified as embryonal RMS (ERMS) and alveolar RMS (ARMS), represents the most frequent soft tissue sarcoma in the pediatric population; the latter shows greater aggressiveness and metastatic potential with respect to the former.
12p
vimale2711
25-08-2020
7
1
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Rhabdomyosarcomas (RMSs) are the most frequent soft tissue sarcoma in children and adolescents, defined by skeletal muscle differentiation and the status of FOXO1 fusions. In pediatric malignancies, in particular RMS, scant and controversial observations are reported about PD-L1 expression as a putative biomarker and few immune checkpoint clinical trials are conducted.
9p
vibaku2711
22-07-2020
10
2
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In pediatric sarcomas, outcomes of established therapies still remain poor, especially due to highgrade resistances to chemotherapeutic compounds. Taking novel biological approaches into account, virotherapy was found to be efficient in many pediatric sarcoma types.
15p
vikuala271
13-06-2020
10
1
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Cancer patients with advanced disease routinely exhaust available clinical regimens and lack actionable genomic medicine results, leaving a large patient population without effective treatments options when their disease inevitably progresses.
23p
vikuala271
13-06-2020
5
0
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About 2000 children and adolescents under the age of 18 are diagnosed with cancer each year in Germany. Because of current medical treatment methods, a high survival rate can be reached for many types of the disease. Nevertheless, patients face a number of long-term effects related to the treatment.
8p
vivalanbo2711
19-03-2020
10
1
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Kaposi’s sarcoma (KS), an endothelial neoplasm, is associated with human herpes virus (HHV) -8 infection. KS has four clinical sub-types: Mediterranean/classic, African/endemic, human immunodeficiency virus (HIV) -associated/epidemic, and transplantation-related/iatrogenic.
7p
videshiki2711
21-02-2020
21
1
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Rhabdomyosarcoma (RMS), one of the most common soft tissue sarcomas of childhood, is very rare in the neonatal period (0.4–2% of cases). In order to gain a deeper understanding of this disease at such age, patient and tumor features, as well as treatment modality and outcome need to be reported.
5p
vidr2711
19-02-2020
13
1
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There is no established standard chemotherapy for recurrent pediatric solid tumors such as neuroblastoma and sarcoma. Since some of these tumor cells show dysfunctions in homologous recombination repair, the goal is to conduct a phase I study of olaparib, a poly(ADP-ribose) polymerase inhibitor.
7p
vidublin2711
13-01-2020
10
1
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(bq) part 1 book "pediatric malignancies pathology and imaging" presentation of content: laboratory techniques used in the diagnosis of pediatric tumors, imaging techniques used in the diagnosis of pediatric tumors, soft tissue sarcomas, malignant bone tumors, tumors of lymphoid and hematopoietic tissues, tumors of the central nervous system.
209p
thangnamvoiva23
06-10-2016
45
4
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(bq) part 1 book "practical soft tissue pathology - a diagnostic approach" presentation of content: tumor classification and immunohistochemistry, biologic potential, grading, staging, and reporting of sarcomas, spindle cell tumors of adults, pediatric spindle cell tumors, tumors with myxoid stroma,... and other contents.
256p
thangnamvoiva23
06-10-2016
37
4
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Một phản ứng kém với điều trị. Osteogenic sarcoma xương cánh tay trái gần một cô gái 14 tuổi. Top hàng cho thấy pretherapy MRI (T1 postgadolinium) và nghiên cứu 18F-FDG. MRI cho thấy phá hủy được đánh dấu của xương cánh tay gần với khối u qua các tấm tăng trưởng, hoại tử xương trung tâm, và các mô mềm mở rộng khối u đại chúng.
59p
meomap5
12-12-2011
70
5
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