Pedigree method

Noninvasive prenatal testing (NIPT) of recessive monogenic diseases depends heavily on knowing the correct parental haplotypes. However, the currently used family-based haplotyping method requires pedigrees, and molecular haplotyping is highly challenging due to its high cost, long turnaround time, and complexity.

9p vibransone 28-03-2024 13 2   Download

For dichotomous traits, the generalized disequilibrium test with the moment estimate of the variance (GDT-ME) is a powerful family-based association method. Genomic imprinting is an important epigenetic phenomenon and currently, there has been increasing interest of incorporating imprinting to improve the test power of association analysis.

12p vinarcissa 21-03-2023 3 1   Download

The objective of this paper was (i) to compare the performance of 10 additive-dominance predictive models (including current models and proposed modifications), fitted using Bayesian, Lasso and Ridge regression approaches; and (ii) to decompose genomic heritability and accuracy in terms of three quantitative genetic information sources, namely, linkage disequilibrium (LD), co-segregation (CS) and pedigree relationships or family structure (PR).

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We propose a gene-level association test that accounts for individual relatedness and population structures in pedigree data in the framework of linear mixed models (LMMs). Our method data-adaptively combines the results across a class of score-based tests, only requiring fitting a single null model (under the null hypothesis) for the whole genome, thereby being computationally efficient.

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The results indicated that for eggplant improvement, additive variation is of great importance and makes it possible to successfully select better individuals in segregating populations, since the selective gains will depend only on gametic variation. For this reason, backcross, pedigree, single-seed descent or gametic selection methods are recommended for advancing the segregating populations.

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Pedigree files are ubiquitously used within bioinformatics and genetics studies to convey critical information about relatedness, sex and affected status of study samples. While the text based format of ped files is efficient for computational methods, it is not immediately intuitive to a bioinformatician or geneticist trying to understand family structures, many of which encode the affected status of individuals across multiple generations.

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Genomic imprinting is one of the well-known epigenetic factors causing the association between traits and genes, and has generally been examined by detecting parent-of-origin effects of alleles. A lot of methods have been proposed to test for parent-of-origin effects on autosomes based on nuclear families and general pedigrees.

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Genomic prediction is an advanced method for estimating genetic values, which has been widely accepted for genetic evaluation in animal and disease-risk prediction in human. It estimates genetic values with genome-wide distributed SNPs instead of pedigree.

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OL 12 is a single cut fodder variety released by State Variety Approval committee for general cultivation in Punjab state during the year 2018. This variety has been developed from the cross between Kent x OL 125 through pedigree method of selection. Its plants are tall with profuse tillering and leafy growth. The leaves are longer and broader (Fig. 1). The salient morphological characteristics of this variety are presented in Table 1. On an average, it attains plant height of 138 cm. It has higher leaf to stem ratio, stem thickness and bears more number of tillers per plant.

5p angicungduoc6 22-07-2020 11 2   Download

Maple syrup urine disease (MSUD) is an autosomal recessive inherited metabolic disorder caused by malfunction of the branched-chain α-ketoacid dehydrogenase complex (BCKDH). This enzyme complex participates in the catalyzing metabolisms of the branched-chain αketoacids, the second step of the degradation of branched-chain amino acids. Impaired activities of the BCKAD complex lead to an increase of the levels of branched- chain amino acid such as leucine, valine, and isoleucine in the blood.

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The rice variety Ratnagiri-8 (IET 25493; RTN 28-1-5-3-2) was evolved from the cross between IR64 and Karjat 184 using former parent as female through pedigree method of selection. The above variety is midlate in duration (135-138 days in Kharif), Semi-dwarf (102-110 cm plant height). Ratnagiri 8 rice variety recorded 38.52% higher grain yield over HYV’s medium slender check Palghar 1 pooled over five years testing in Station Trial.

18p nguathienthan5 04-06-2020 11 0   Download

An investigation was carried out with thirty six blackgram genotypes in rice fallow situation, to assess the variability, heritability and genetic advance for yield and yield attributing characters. The results revealed that high PCV and GCV for number of clusters per plant and high PCV coupled with moderate GCV for number of branches per plant and grain yield per plant exhibiting wider range of variability. Whereas, number of pods per plant and 100 seed weight recorded moderate variability.

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Tomato (Solanum lycopersicum L.) is one of the most important vegetable crops under solanaceous group which can be grown both under open field conditions and greenhouses. Tomato has achieved high popularity especially in the recent years because of lycopene’s anti-oxidative activities and anti-cancerous functions. The cultivated tomato has been used in genetic studies because of the ease with which it can be easily manipulated and also its diversity present within the population.

9p kequaidan2 13-12-2019 15 0   Download

The following study was conducted in order to compare the modified single-seed descent method of selection used in soybean breeding at the Institute of Field and Vegetable Crops in Novi Sad, Serbia, with the standard bulk method and the pedigree method.

12p vimb123 12-01-2019 22 1   Download

Prenatal diagnosis, traditionally used as a synonymous for invasive fetal testing and evaluation of chromosomal constellation, presently encompasses many other issues like pedigree analyses, fetal risk assessment, population screening, genetic counseling and fetal diagnostic testing as well. Ultrasound guided chorionic villus samling (CVS), amniocentesis and, to a lesser extent, fetal blood sampling are used routinely in fetal medicine units. Other fetal tissue biopsies such as skin, liver and muscle biopsy are used only rarely.

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Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: A rapid conditional enumeration haplotyping method in pedigrees

12p toshiba19 08-11-2011 40 3   Download

Chọn lọc phả hệ (Pedigree method). Phương pháp này có hiệu quả tốt, tập trung chọn lọc ra các kiểu gen cần thiết, được phân lập chi tiết ngay từ quần thể phân li F2. Ở kết quả có thể thu được các dòng giá trị, chúng được đánh giá khá chuẩn xác trước khi đưa thử nghiệm.

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Table 62-8 Genetic Approaches for Identifying Disease Genes Method Indications Advantages and Limitations Linkage Studies Classical linkage analysis Analysis of Difficult to collect (parametric monogenic traits large informative pedigrees methods) Suitable for genome scan Difficult to obtain sufficient statistical power for complex traits Control not required population Useful for multifactorial disorders in isolated populations Allele-sharing Suitable for Difficult to collect methods (nonparametric identification methods) susceptibility genes of sufficient nu...

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