Peptide design

Ebook "Protein design: Methods and applications (Second edition)" expands upon the previous edition with current, detailed ideas on how to approach a potential protein design project. With new chapters on metals as structure-forming elements and functional sites, the design and characterization of fluorinated proteins, top-down symmetric deconstruction and the design of protein libraries and novel or repurposed enzymes.

291p dongmelo 27-05-2024 5 2   Download

Ebook "Designing receptors for the next generation of biosensors" shows how synthetic receptors can be designed with characteristics that make them attractive alternatives to biological molecules in the sensory and diagnostics fields, with contributions from leading experts in the area.

271p coduathanh1122 27-03-2024 3 1   Download

Ebook Biomolecular simulations in structure-based drug discovery - Part 1 includes content: Predictive power of biomolecular simulations, molecular dynamics–based approaches describing protein binding, markov state models in drug design, understanding the structure and dynamics of peptides and proteins through the lens of network science,… and other contents.

172p longtimenosee03 01-02-2024 1 0   Download

Ebook "Biomolecular imaging at high spatial and temporal resolution in vitro and in vivo" gives the first molecular description of a de-novo designed peptide-based material. In general, this research will have a huge impact on the peptide assembly field, and also in electron microscopy as it introduces new methods and approaches, all of which are Thom's inventions and are described in this thesis.

161p nhanphanguyet 28-01-2024 3 2   Download

Ebook "Modeling peptide-protein interactions: Methods and protocols" covers an array of techniques available for studying peptide-protein docking and design. The book is divided into four sections: peptide binding site prediction; peptide-protein docking; prediction and design of peptide binding specificity; and the design of inhibitory peptides. The chapters in Modeling Peptide-Protein Interactions: Methods and Protocols cover topics such as the usage of ACCLUSTER and PeptiMap for peptide binding site prediction;...

311p lucchinguyen 28-12-2023 5 2   Download

Part 2 book "Vaccine design, methods and protocols (Vol 2 - Vaccines for veterinary diseases)" includes content: Strategies for vaccine design using phage display derived peptides, laboratory scale production of recombinant HAA86 tick protein in pichia pastoris and in escherichia coli system; transient expression of viral proteins in plants using agrobacterium tumefaciens, recombinant botulinum toxoids - a practical guide for production,.... and other contents.

433p oursky05 20-09-2023 1 0   Download

Part 1 book "Vaccine design, methods and protocols (Vol 2 - Vaccines for veterinary diseases)" includes content: Challenges in veterinary vaccine development and immunization, development of mycoplasma hyopneumoniae recombinant vaccines, computational prediction of immunodominant epitopes on outer membrane protein (OPM) H of pasteurella multocida toward designing of a peptide vaccine; DNA vaccines against maedi–visna virus, detection of avian antigen specific T-cells induced by viral vaccines,.... and other contents.

445p oursky05 20-09-2023 0 0   Download

In the present investigation, sea rough fish were hydrolyzed with alcalase/peptidase combined enzymes (EA/EP). Raw material proximate composition was investigated. The results indicated that sea rough fish was successfully converted into hydrolysates that mainly composed of small size peptides and free amino acids. The essential amino acid could be served as a valuable source of nutrition for humans and animals.

10p viannee 02-08-2023 3 3   Download

To propose a novel modeling of aflatoxin immunization and surrogate toxin conjugate from AFB1 vaccines, an immunogen based on the mimotope, (i.e. a peptide-displayed phage that mimics aflatoxins epitope without toxin hazards) was designed.

10p vihermione 06-01-2023 6 3   Download

Oromucosal administration is an attractive non-invasive route. However, drug absorption is challenged by salivary flow and the mucosa being a significant permeability barrier. The aim of this study was to design and investigate a multi-layered nanofiber-on-foam-on-film (NFF) drug delivery system with unique properties and based on polysaccharides combined as i) mucoadhesive chitosan-based nanofibers, ii) a peptide loaded hydroxypropyl methylcellulose foam, and iii) a saliva-repelling backing film based on ethylcellulose.

10p vihermione 30-12-2022 42 2   Download

We investigated and compared the robustness of supercritical fluid chromatography (SFC) separations of the peptide gramicidin, using either isocratic or gradient elution. This was done using design of experiments in a design space of co-solvent fraction, water mass fraction in co-solvent, pressure, and temperature.

11p viginny 23-12-2022 7 3   Download

(BQ) Ebook part 1 presents the following content: Chapter 1: Self-Assembling Cyclic Peptide-Based Nanomaterials; Chapter 2: Designer Nanomaterials for the Production of Energy and High Value-Added Chemicals; Chapter 3: Supramolecular Receptors for Fullerenes; Chapter 4: Click Chemistry: A Quote for Function; Chapter 5: Supramolecular Interactions and Smart Materials: C–X…X′–M Halogen Bonds and Gas Sorption in Molecular Solids; Chapter 6: Application of Advanced Solid-State NMR Techniques to the Characterization of Nanomaterials: A Focus on Interfaces and Structure; Chapter 7: New Tools for ...

248p runordie7 30-08-2022 9 2   Download

Our focus in this study is on the design and synthesis of a light-responsive peptide-based nanocarrier in order to develop effective and biocompatible drug delivery systems. The synthesized nanocarrier is basically composed of peptide amphiphiles comprising a micelle forming a Pro-Pro-Pro-Lys-Lys-Lys peptide sequence with an attached anthracene fluorophore. Anthracene containing an inner core of the micelle can serve as a storage site for poorly watersoluble drugs.

10p tudichquannguyet 29-11-2021 13 0   Download

Mutant peptides presented by MHC (major histocompatibility complex) Class II in cancer are important targets for cancer immunotherapy. Both animal studies and clinical trials in cancer patients showed that CD4 T cells specific to tumor-derived mutant peptides are essential for the efficacy of immune checkpoint blockade therapy by PD1 antibody.

9p vitzuyu2711 29-09-2021 10 1   Download

CD4+ T-cell epitopes play a crucial role in eliciting vigorous protective immune responses during peptide (epitope)-based vaccination. The prediction of these epitopes focuses on the peptide binding process by MHC class II proteins. The ability to account for MHC class II polymorphism is critical for epitope-based vaccine design tools, as different allelic variants can have different peptide repertoires.

11p viwyoming2711 16-12-2020 20 1   Download

In past, a number of peptides have been reported to possess highly diverse properties ranging from cell penetrating, tumor homing, anticancer, anti-hypertensive, antiviral to antimicrobials.

8p vikentucky2711 26-11-2020 10 1   Download

Understanding the interactions between antibodies and the linear epitopes that they recognize is an important task in the study of immunological diseases. We present a novel computational method for the design of linear epitopes of specified binding affinity to Intravenous Immunoglobulin (IVIg).

13p vioklahoma2711 19-11-2020 12 2   Download

Conventional de novo drug design is costly and time consuming, making it accessible to only the best resourced research organizations. An emergent approach to new drug development is drug repurposing, in which compounds that have already gone through some level of clinical testing are examined for efficacy against diseases divergent than their original application.

11p viconnecticut2711 28-10-2020 17 1   Download

Bioinformatics methods are helpful to identify new molecules for diagnostic or therapeutic applications. For example, the use of peptides capable of mimicking binding sites has several benefits in replacing a protein which is difficult to produce, or toxic. Using peptides is less expensive.

14p vijisoo2711 27-10-2020 9 0   Download

Computational methods provide approaches to identify epitopes in protein Ags to help characterizing potential biomarkers identified by high-throughput genomic or proteomic experiments. PEPOP version 1.0 was developed as an antigenic or immunogenic peptide prediction tool.

17p vicolorado2711 23-10-2020 10 0   Download