Peptide nucleic acids

G-quadruplex (G4) là acid nucleic có cấu trúc bậc hai được hình thành bởi các trình tự giàu guanine. G4 hiện diện phổ biến trong tất cả các bản phiên mã và bộ gen của sinh vật. Bài viết tập trung thảo luận về những ứng dụng của tương tác đặc hiệu giữa peptide RHAU và G4 song song trong những phản ứng sinh hóa.

11p vithomson 02-07-2024 0 0   Download

Ebook "Innate immunity of plants, animals, and humans (Nucleic acids and molecular biology, Volume 21)" wants to give an overview of our current knowledge about the innate immune system of plants, animals and humans. It not only covers the innate immune mechanisms and responses of so diverse organisms such as plants, Cnidaria, Drosophila, urochordates and zebrafish, but also the major receptor systems in mammalians and humans as well as the central defense mechanisms, antimicrobial peptides and the complement system.

248p tachieuhoa 28-01-2024 3 2   Download

Exerkines are all peptides, metabolites, and nucleic acids released into the bloodstream during and after physical exercise. Exerkines liberated from skeletal muscle (myokines), the heart (cardiokines), liver (hepatokines), white adipose tissue (adipokines), brown adipose tissue (batokines), and neurons (neurokines) may benefit health and wellbeing.

21p vioracle 29-09-2023 4 2   Download

Ebook Principles of biochemistry (8th edition): Part 1 includes content: The foundations of biochemistry; water, the solvent of life; amino acids, peptides, and proteins; the three dimensional structure of proteins protein function enzymes carbohydrates and glycobiology; nucleotides and nucleic acids; DNA-Based information technologies.

1283p oursky05 20-09-2023 2 2   Download

Part 1 of ebook "Lehninger principles of biochemistry (7th edition)" provides readers with contents including: the foundations of biochemistry; amino acids, peptides, and proteins; the three-dimensional structure of proteins; protein function; carbohydrates and glycobiology; nucleotides and nucleic acids; DNA-based information technologies;...

1486p lytamnguyet 04-08-2023 8 4   Download

Part 1 of ebook "Principles of biochemistry (4th edition)" provide readers with content about: the foundations of biochemistry; structure and catalysis; water; amino acids, peptides, and proteins; the three-dimensional structure of proteins; protein function; enzymes; carbohydrates and glycobiology; nucleotides and nucleic acids; DNA-based information technologies; lipids; biological membranes and transport; biosignaling; bioenergetics and metabolism; principles of bioenergetics;...

526p hanlinhchi 11-11-2022 12 3   Download

The use of salivary biomarkers has garnered attention because the composition of saliva refects the body’s physiological state. Saliva contains a wide range of components, including peptides, nucleic acids, electrolytes, enzymes, and hormones.

9p vidarwin 22-02-2022 10 1   Download

The RCSB Protein Data Bank (PDB) provides public access to experimentally determined 3D-structures of biological macromolecules (proteins, peptides and nucleic acids). While various tools are available to explore the PDB, options to access the global structural diversity of the entire PDB and to perceive relationships between PDB structures remain very limited.

15p vioklahoma2711 19-11-2020 14 1   Download

Analysis of high microsatellite instability (MSI-H) phenotype in colorectal carcinoma (CRC) is important for evaluating prognosis and choosing a proper adjuvant therapy. Although the conventional MSI analysis methods such as polymerase chain reaction (PCR) fragment analysis and immunohistochemistry (IHC) show high specificity and sensitivity, there are substantial barriers to their use.

10p viputrajaya2711 22-06-2020 13 0   Download

In this paper, we reported a system for the ultrasensitive fluorescence detection of cytokeratin fragment antigen 21–1 DNA (CYFRA21-1 DNA) for the early diagnosis of lung cancer. The approach used electron transfer atom transfer radical polymerization (ARGET-ATRP) with ethylenediaminetetraacetic acid (EDTA) as the metal ligand. Firstly, thiolated peptide nucleic acid (PNA) was linked to aminated magnetic beads solutions (MBs) by a cross-linking agent and then hybridized with CYFRA21-1 DNA (tDNA).

8p partimesinhvien 08-05-2020 34 1   Download

Với sự phát triển của khoa học, vai trò và ý nghĩa của protein đối với sự sống càng được khẳng định. Cùng với nucleic acid, protein là cơ sở vật chất của sự sống. Bài giảng thông tin đến quý độc giả các nội dung kiến thức cấu tạo chung của Amino acid, một số tính chất của amino acid, các phương pháp xác định peptide, số lượng xoắn α và phiến gấp β trong chuỗi đơn một số protein...

32p partimesinhvien 05-05-2020 60 2   Download

Gene synthesis is becoming an important tool in many fields of recombinant DNA technology, including recombinant protein production. De novo gene synthesis is quickly replacing the classical cloning and mutagenesis procedures and allows generating nucleic acids for which no template is available.

13p vihamax2711 21-04-2020 21 2   Download

The application of antisense molecules, such as morpholino oligonucleotides, is an efficient method of gene inactivation in vivo. We recently introduced phosphonic ester modified peptide nucleic acids (PNA) for in vivo loss-of-function experiments in medaka embryos.

14p vihamax2711 21-04-2020 9 0   Download

Lung cancer is one of the quickest and most fatal diseases and is divided into two types: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). Approximately 50% of NSCLC patients harbour mutations in the epidermal growth factor receptor (EGFR) gene, spanning from exon 18 to exon 21, which are responsible for the tyrosine kinase domain of the EGFR protein. Currently, gefitinib and erlotinib are two drugs inhibiting EGFR which are used in the treatment of lung cancer. The indication for use of these drugs depends on the mutation status of EGFR.

8p caygaocaolon1 13-11-2019 34 1   Download

(bq) part 2 book "fundamentals of organic chemistry" has contents: carbonyl alpha substitution reactions and condensation reactions, structure determination, the organic chemistry of metabolic pathways; biomolecules - lipids and nucleic acids; biomolecules - amino acids, peptides, and proteins,...and other contents.

335p bautroibinhyen20 06-03-2017 48 9   Download

(bq) part 2 book "organic chemistry" has contents: alcohols, diols and thiols; ethers, epoxides and sulfides; enols and enolates, carboxylic acids, ester enolates, amino acids, peptides, and proteins. nucleic acids, carbohydrates, carboxylic acid derivatives - nucleophilic acyl substitution... and other contents.

666p bautroibinhyen20 06-03-2017 50 8   Download

(bq) part 1 book "organic chemistry" has contents: organometallic compounds, carboxycilic acids, enols and enolates, carbohydrates; nucleosides, nucleotides, and nucleic acids; amino acids, peptides, and proteins; lipids, amines; ethers, epoxides, and sulfides,...and other contents.

657p bautroibinhyen20 06-03-2017 40 6   Download

(NB) Phần 1 giáo trình "Hóa sinh học" cung cấp cho người học các kiến thức từ chương 1 đến chương 6 bao gồm: Glucid, lipid, acid amin, protein và peptid, acid nucleic, emzym, hormon. Sách được dùng làm tài liệu học tập và nghiên cứu cho sinh viên ngành Hóa dược.

127p bautroibinhyen8 17-12-2016 1276 83   Download

Human immunodeficiency virus type 1 protein R (HIV-1 Vpr) promotes nuclear entry of viral nucleic acids in nondividing cells, causes G2 cell cycle arrest and is involved in cellular differentiation and cell death. Vpr subcellular localization is as variable as its functions. It is known, that consistent with its role in nuclear transport, Vpr localizes to the nuclear envelope of human cells. Further, a reported ion channel activity of Vpr is clearly dependent on its localization in or at membranes.

6p system191 01-06-2013 31 3   Download

The decoy approach against nuclear factor kB (NF-kB) is a useful tool to alter NF-kB dependent gene expression using synthetic oligonucleotides (ODNs) carrying NF-kB specific cis-elements. Unfortunately, ODNs are not stable and need to be extensively modified to be used in vivo or ex vivo. We have previously evaluated the possible use of peptide nucleic acids (PNAs) as decoy molecules. The backbone of PNAs is composed of N-(2-aminoethyl)glycine units, rendering these molecules resistant to both nucleases and proteases.

10p system191 01-06-2013 41 3   Download