Personalization of treatment

Radiotherapy is a mainstay of cancer treatment. The clinical response to radiotherapy is heterogeneous, from a complete response to early progression. Recent studies have explored the importance of patient characteristics in response to radiotherapy. In this editorial, we invite contributions for a BMC Cancer collection of articles titled ‘Advances in personalized radiotherapy’ towards the improvement of treatment response.

3p vishanshan 27-06-2024 2 1   Download

Germline mutations in BRCA1 and BRCA2 genes are among the main causes of hereditary ovarian cancer. Identifying these mutations may reduce cancer risk, facilitate early detection, and enable personalized treatment.

6p vishanshan 27-06-2024 1 1   Download

This study aims to develop a nomogram integrating inflammation (NLR), Prognostic Nutritional Index (PNI), and EBV DNA (tumor burden) to achieve personalized treatment and prediction for stage IVA NPC. Furthermore, it endeavors to pinpoint specific subgroups that may derive significant benefits from S-1 adjuvant chemotherapy.

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Treatment summaries and a personalized survivorship care plans based on internationally approved, organ-specific follow-up care recommendations are essential in preserving the health and quality of life for cancer survivors.

10p vikoch 27-06-2024 3 1   Download

A food allergy is an abnormal response of the body to a certain food. Food allergy is described as an increasing disease over time in the community expectly in children. Mechanism of food allergy is complicated such as due to IgE, non IgE and mix. Symptoms of an allergic reaction can vary in type and severity, and some may even be fatal. Allergic reactions may also differ from person-toperson and change over time.

6p vicarlos 11-06-2024 1 0   Download

A comprehensive understanding of cancer has been furthered with technological improvements and decreasing costs of next-generation sequencing (NGS). However, the complexity of interpreting genomic data is hindering the implementation of high-throughput technologies in the clinical context: increasing evidence on gene–drug interactions complicates the task of assigning clinical significance to genomic variants.

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Personalized care of cancer patients undergoing treatment with immune checkpoint inhibitors will require approaches that can predict their susceptibility to immune-related adverse events. Understanding the role of germline genetic factors in determining individual responses to immunotherapy will deepen our understanding of immune toxicity and, importantly, it may lead to tools for identifying patients who are at risk.

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The analysis of circulating tumor cells (CTCs) is an outstanding tool to provide insights into the biology of metastatic cancers, to monitor disease progression and with potential for use in liquid biopsy-based personalized cancer treatment.

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Tumor cell-intrinsic mechanisms and complex interactions with the tumor microenvironment contribute to therapeutic failure via tumor evolution. It may be possible to overcome treatment resistance by developing a personalized approach against relapsing cancers based on a comprehensive analysis of cell typespecific transcriptomic changes over the clinical course of the disease using single-cell RNA sequencing (scRNA-seq).

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Monitoring treatment and early detection of fatal breast cancer (BC) remains a major unmet need. Aberrant circulating DNA methylation (DNAme) patterns are likely to provide a highly specific cancer signal. We hypothesized that cell-free DNAme markers could indicate disseminated breast cancer, even in the presence of substantial quantities of background DNA.

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Despite a myriad of attempts in the last three decades to diagnose ovarian cancer (OC) earlier, this clinical aim still remains a significant challenge. Aberrant methylation patterns of linked CpGs analyzed in DNA fragments shed by cancers into the bloodstream (i.e. cell-free DNA) can provide highly specific signals indicating cancer presence.

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Multiple sclerosis is a chronic neuroinfammatory disease with a highly heterogeneous disease course. Preventing lasting disability requires early identification of persons at risk and novel approaches towards patient stratification for personalized treatment decisions. In this comment, we discuss the importance of large datasets of real-world cohorts in order to address this unmet need.

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Treatment with tumor necrosis factor α (TNFα) antagonists in IBD patients sufers from primary non-response rates of up to 40%. Biomarkers for early prediction of therapy success are missing. We investigated the dynamics of gene expression and DNA methylation in blood samples of IBD patients treated with the TNF antagonist infliximab and analyzed the predictive potential regarding therapy outcome.

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Part 1 book "Fast facts for the critical care nurse - Critical care nursing in a nutshell" includes content: Critical care nursing overview, the importance of documentation, advance directives and organ donation, withdrawal of treatment and palliative care, basic patient care in the critical care setting, patient nutrition, the sterile field, pre procedural patient preparation and consciouns sedation, isolation precautions and personal protective equipment, everything iv.

122p muasambanhan09 16-03-2024 2 1   Download

The precise characterization of individual tumors and immune microenvironments using transcriptome sequencing has provided a great opportunity for successful personalized cancer treatment.

21p vicwell 29-02-2024 3 2   Download

Part 1 book "Handbook of formulating dermal applications" includes content: Pre formulation design and considerations, the use of thickeners in topically applied formulations, the incorporation of delivery systems into topical formulations - a case study on the use of salicylic acid for acne treatment, formulating skin care products with silicones - approaches and strategies, th e use of corn derived ingredients in personal care applications,... and other contents.

351p muasambanhan08 23-02-2024 3 1   Download

Ebook "Green technologies for wastewater treatment: Energy recovery and emerging compounds removal" evaluates water management together with energy use. The strong effects that the release of emerging pollutants such as endocrine disruptors (EDCs), pharmaceuticals and personal care products (PPCPs) have in wastewater reuse applications are examined, as well as the need to optimize the energy consumption in wastewater treatment.

105p nhanphanguyet 28-01-2024 10 2   Download

Stuttering may include repetition of words in whole or part, difficulty saying words, and elongated pauses in speech. Approximately 5% of children stutter for a period lasting 6 months or more. Most of those children stop stuttering as they approach adulthood, but the condition persists in approximately 1% of adults. The cause of stuttering is unknown.

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Since the identification of multiple therapeutic targets, as is the case of anaplastic lymphoma kinase (ALK) translocation, the paradigm of treating patients with non-small cell lung cancer (NSCLC) has improved. In order to guarantee the possibility of longer survival outcomes with a better quality of life we must invest in the determination, in suitable time, of the consensual biomarkers and in the availability of the best treatments to our patients.

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Ebook "Bioinformatics for diagnosis, prognosis and treatment of complex diseases" introduces the bioinformatics tools, databases and strategies for the translational research, focuses on the biomarker discovery based on integrative data analysis and systems biological network reconstruction. With the coming of personal genomics era, the biomedical data will be accumulated fast and then it will become reality for the personalized and accurate diagnosis, prognosis and treatment of complex diseases.

219p lamquandat 28-12-2023 10 2   Download