Pfam domain
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Every genome contains a large number of uncharacterized proteins that may encode entirely novel biological systems. Many of these uncharacterized proteins fall into related sequence families. By applying sequence and structural analysis we hope to provide insight into novel biology.
7p viwyoming2711 16-12-2020 12 1 Download
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A novel highly conserved protein domain, DUF162 [Pfam: PF02589], can be mapped to two proteins: LutB and LutC. Both proteins are encoded by a highly conserved LutABC operon, which has been implicated in lactate utilization in bacteria.
9p viwyoming2711 16-12-2020 11 1 Download
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N-terminal domains of BVU_4064 and BF1687 proteins from Bacteroides vulgatus and Bacteroides fragilis respectively are members of the Pfam family PF12985 (DUF3869). Proteins containing a domain from this family can be found in most Bacteroides species and, in large numbers, in all human gut microbiome samples.
9p vikentucky2711 26-11-2020 10 2 Download
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Many entries in the protein data bank (PDB) are annotated to show their component protein domains according to the Pfam classification, as well as their biological function through the enzyme commission (EC) numbering scheme.
11p vioklahoma2711 19-11-2020 8 1 Download
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The seed and full alignments, accompanied by annotation and cross-references to other family and structure databases and to the literature and the HMMs, are what make up Pfam-A. Each family has a permanent accession number and can thus be referenced from other databases. For release 1.0, we strived to include every family with more than 50 members in Pfam-A. All sequence domains not in Pfam-A were then clustered and aligned automati- cally by the Domainer program into Pfam-B. To- gether, Pfam-A and Pfam-B provide a complete clus- tering of all protein sequences.
12p yasuyidol 02-04-2013 71 4 Download
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At publication, the database lists 22 studies linking pesticides to reproductive health effects. These include decreased fertility in both males and females, antiandrogenic (demasculinizing) effects, increased rates of miscarriage, altered sex ratios and altered maturity. A 2006 study published in the journal Epidemiology has found inverse associations between pesticides and male testosterone levels.
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