Pharmaco-kinetics

Part 1 book "Rang and Dale's pharmacology" includes content: Cell proliferation, apoptosis, repair and regeneration; cellular mechanisms; method and measurement in pharmacology; drug absorption and distribution; drug metabolism and elimination; pharmacokinetics; pharmacogenetics, pharmacogenomics and ‘personalised medicine’; chemical mediators and the autonomic nervous system,... and other contents.

357p dianmotminh03 03-06-2024 3 0   Download

Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery.

607p vimeyers 29-05-2024 2 2   Download

A description of our current understanding of antiepileptic drug use during pregnancy, this book includes chapters on the impact of seizures on the mother and developing child, changes in maternal physiology during pregnancy and its impact on drug disposition, and the pharmacokinetic differences between the various anti-seizure medications.

235p vimeyers 29-05-2024 7 2   Download

This reference provides a concise overview of the key principles in dose selection and optimization and demonstrates applicability to recent successful new drug applications. Compiling key issues and current research on safety, efficacy, and clinical pharmacology, and PK-PD, this volume critically highlights the multidisciplinary nature of drug development and spans the fields of pharmacokinetics, clinical pharmacology, biostatistics, and experimental medicine.

301p vimeyers 29-05-2024 4 2   Download

Part 1 book "Basic and clinical pharmacology" includes contents: Introduction - The nature of drugs and drug development and regulation, drug receptors and pharmacodynamics, pharmacokinetics and pharmacodynamics - rational dosing and the time course of drug action, drug biotransformation, pharmacogenomics, introduction to autonomic pharmacology; cholinoceptor activating and cholinesterase inhibiting drugs; cholinoceptor blocking drugs; adrenoceptor agonists and sympathomimetic drugs, adrenoceptor antagonist drugs,... and other contents.

502p dianmotminh01 17-05-2024 3 3   Download

his study focused on finding alkaloid compounds collected from Chemfaces database that inhibit HER2 enzyme employing computational methods such as molecular docking and ADMET prediction. Out of 118 phytochemicals docked to the ATP binding site of the HER2 kinase domain, 10 alkaloid compounds exhibited higher binding affinity than the reference inhibitor and satisfied the Lipinski’s rule of five. All compounds have good pharmacokinetic properties.

10p dianmotminh02 03-05-2024 4 3   Download

Part 1 book "Anaesthesia science" includes content: Pharmacokinetic principles, pharmacodynamics, pharmacogenomics, receptors and second messenger systems, anaphylaxis, reflections on chirality, ion channels, immunosuppression, use and abuse of antibiotics, inflammation and immunity.

208p zizaybay1101 30-04-2024 3 2   Download

Part 1 book "Clinical pharmacy and therapeutics" includes content: Clinical pharmacy process, practical pharmacokinetics, drug interactions, adverse drug reactions, laboratory data, parenteral nutrition, liver disease, cute kidney injury, chronic kidney disease and end-stage renal disease, coronary heart disease.

493p zizaybay1101 30-04-2024 3 2   Download

Variability in drug efficacy and adverse effects are observed in clinical practice. While the extent of genetic variability in classic pharmacokinetic genes is rather well understood, the role of genetic variation in drug targets is typically less studied.

15p vioraclene 31-03-2024 5 1   Download

Efflux transporters like MDR1 and MRP2 may modulate the pharmacokinetics of about 50 % of all drugs. It is currently unknown how much of the variation in the activities of important drug membrane transporters like MDR1 or MRP2 is determined by genetic or by environmental factors. In this study we assessed the heritability of the pharmacokinetics of talinolol as a putative probe drug for MDR1 and possibly other membrane transporters.

12p vioraclene 31-03-2024 10 2   Download

Ebook "Reducing drug attrition (Topics in Medicinal chemistry, Volume 11)" is to provide guidance to those persons who are dedicated to the creation and development of new drugs to aid patients. Our aim was to address the key factors that have led to failure of preclinical and clinical drug candidates. Despite the significant scientific advances over the past few decades in the disciplines associated with research and development (R&D), the overall productivity, as measured by new approved drugs, has not improved.

176p tudohanhtau1006 29-03-2024 1 1   Download

Part 1 book "Drug delivery - Engineering principles for drug therapy" includes content: Introduction, drug administration and drug effectiveness, diffusion and drug dispersion, diffusion in biological systems, drug permeation through biological barriers, drug transport by fluid motion, pharmacokinetics of drug distribution.

209p muasambanhan09 12-03-2024 4 0   Download

Ebook Boh’s pharmacy practice manual: A guide to the clinical experience (fourth edition) - Part 2 includes content: Fluid and electrolyte therapy, enteral nutrition, parenteral nutrition, pharmacy calculations, clinical pharmacokinetics, clinical drug monitoring, pain management, vaccines and pharmacists as immunizers,… and other contents.

321p longtimenosee03 01-02-2024 1 0   Download

Part 1 book "Rang and Dale's pharmacology" includes content: How drugs act, how drugs act, how drugs act, how drugs act, cell proliferation, apoptosis, repair and regeneration, cellular mechanisms, method and measurement in pharmacology, absorption and distribution of drugs, drug metabolism and elimination, pharmacokinetics, individual variation, pharmacogenomics and personalised medicine,... and other contents.

413p muasambanhan05 22-01-2024 4 2   Download

Ebook "Betalains: Biomolecular aspects" provides comprehensive coverage of betalains, outlining the specific makeup and uses of this plant. The chapters provide deep insight into the biosynthesis, structures, pharmacokinetics, stability, extraction, health benefits and occurrence in nature of betalains. As the first major reference work to focus specifically on betalains, this book serves as an important reference for any researcher looking for insights into the use of betalains as functional foods, food coloring agents, and nutraceuticals.

193p lamquandat 28-12-2023 6 2   Download

Ebook "Drug target miRNA: Methods and protocols" provides a concise and technical discussion of recently developed approaches to overcome challenges, such as pharmacodynamics and pharmacokinetics difficulties, in miRNA drug discovery. These strategies cover anti-sense agents targeting miRNA that are applied in advanced formulations or are chemically optimized to increase delivery; small molecule miRNA modulators to overcome anti-sense agents’ limitations; general enhancers of miRNA maturation; and Argonaute 2 protein and its pharmacokinetic parameters.

318p lucchinguyen 28-12-2023 3 2   Download

Part 1 book "Small animal clinical pharmacology and therapeutics" includes content: Principles of clinical pharmacology, clinical pharmacokinetics, adverse drug reactions, the pharmacology of the autonomic nervous system, anesthetic agents, behavior-modifying drugs, antibacterial drugs, systemic antifungal therapy, antiparasitic drugs,.... and other contents.

484p muasambanhan03 25-12-2023 3 1   Download

Part 1 book "Small animal clinical pharmacology" includes content: Principles of clinical pharmacology, clinical pharmacokinetics, adverse drug reactions, the pharmacology of the autonomic nervous system, anesthetic agents, sedatives, behavior modifying drugs, antibacterial drugs, systemic antifungal therapy, antiparasitic drugs, glucocorticosteroids and antihistamines, immunomodulatory therapy.

291p muasambanhan03 25-12-2023 4 1   Download

The mammalian target of rapamycin (mTOR) kinase, a central component of the PI3K/AKT/mTOR pathway, plays a critical role in tumor biology as an attractive therapeutic target. We conducted this first-in-human study to investigate the safety, pharmacokinetics (PK), and pilot efficacy of LXI-15029, an mTORC1/2 dual inhibitor, in Chinese patients with advanced malignant solid tumors.

12p vialfrednobel 23-12-2023 2 2   Download

As a potential target receptor tyrosine kinase, mesenchymal-epithelial transition factor (MET) exhibits high aberrant expression across various tumors. This study aimed to evaluated the safety, tolerability, efficacy and pharmacokinetics (PK) of BPI-9016M, a novel tyrosine kinase inhibitor (TKI) targeting c-MET, in c-MET overexpression or MET exon 14 skipping mutation patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC).

13p vischultz 20-10-2023 3 1   Download