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Pharmacokinetic interaction
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Part 1 book "Clinical pharmacy and therapeutics" includes content: Clinical pharmacy process, practical pharmacokinetics, drug interactions, adverse drug reactions, laboratory data, parenteral nutrition, liver disease, cute kidney injury, chronic kidney disease and end-stage renal disease, coronary heart disease.
493p
zizaybay1101
30-04-2024
3
2
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Drug-drug interaction (DDI), which can occur at the pharmacokinetics and/or the pharmacodynamics (PD) levels, can increase or decrease the therapeutic or adverse response of a drug itself or a combination of drugs. Cancer patients often receive, along their antineoplastic agents, antibiotics such as ß-lactams to treat or prevent infection.
11p
vipriyankagandhi
27-07-2022
4
1
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Extracorporeal membrane oxygenation (ECMO) is a supportive therapy and its success depends on optimal drug therapy along with other supportive care. Emerging evidence suggests significant interactions between the drug and the device resulting in altered pharmacokinetics (PK) of vital drugs which may be further complicated by the PK changes that occur in the context of critical illness.
10p
viisaacnewton
26-04-2022
16
1
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This study was taken up to assess the pharmacokinetic alterations of meloxicam if any, following interaction with quercetin pre treatment (10 mg.kg-1 and20 mg.kg-1 ) in rabbits.
7p
chauchaungayxua12
29-07-2021
7
1
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DCE@urLAB is a software application for analysis of dynamic contrast-enhanced magnetic resonance imaging data (DCE-MRI). The tool incorporates a friendly graphical user interface (GUI) to interactively select and analyze a region of interest (ROI) within the image set, taking into account the tissue concentration of the contrast agent (CA) and its effect on pixel intensity.
17p
viwyoming2711
16-12-2020
13
1
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Calcium and magnesium (Ca/Mg) infusions have been suggested as an effective intervention for preventing oxaliplatin-induced neurotoxicity, but the effects of Ca/Mg infusions on oxaliplatin pharmacokinetics, motor nerve hyperexcitability and acute neurotoxicity symptoms are unclear.
9p
vijennie2711
29-09-2020
12
1
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Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects
To investigate the effects of coadministration of esaxerenone with amlodipine on the pharmacokinetics (PK) of each drug, and of esaxerenone on the PK of digoxin.
10p
vidhaka2711
31-07-2020
51
3
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Present study was conducted for pharmacokinetic interaction of long acting moxofloxacin (LA moxifloxacin) with meloxicam at the dose rate of 7.5 mg.kg-1 and 0.5 mg.kg-1 respectively following intramuscular (IM) administration. Peak plasma concentrations of drug were estimated by using HPLC florescence detector
5p
chauchaungayxua6
26-06-2020
11
0
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Rivaroxaban is a direct inhibitor of coagulation factor Xa and is used for venous thromboembolic disorders. The rivaroxaban interaction with BSA was studied to understand its PK and PD (pharmacokinetics and pharmacokinetics) properties.
9p
vijiraiya2711
27-05-2020
14
1
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Disease-mediated therapeutic protein–drug interactions have recently gained attention from regulatory agencies and pharmaceutical industries in the development of new biological products. In this study, we developed a physiologically based pharmacokinetic (PBPK) model using SimCYP to predict the impact of elevated interleukin-6 (IL-6) levels on cytochrome P450 (CYP) enzymes and the treatment effect of an anti-IL-6 monoclonal antibody, sirukumab, in patients with rheumatoid arthritis (RA).
10p
caothientrangnguyen
09-05-2020
17
1
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The physiologically based pharmacokinetic (PBPK) model for liver transporter substrates has been established previously and used for predicting drug–drug interactions (DDI) and for clinical practice guidance. So far, nearly all the published PBPK models for liver transporter substrates have one or more hepatic clearance processes (i.e., active uptake, passive diffusion, metabolism, and biliary excretion) estimated by fitting observed systemic data.
11p
caothientrangnguyen
09-05-2020
18
0
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Pharmacokinetic interactions between rifampicin and protease inhibitors (PIs) complicate the management of HIV-associated tuberculosis. Rifabutin is an alternative rifamycin, for patients requiring PIs.
11p
vienzym2711
03-04-2020
15
1
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The antimalarial activity of plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), a naturally occurring naphthoquinone widely distributed in the Plumbaginaceae family has previously been demonstrated in vitro (good activity) and in vivo (weak activity).
10p
vienzym2711
30-03-2020
13
1
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Cola nitida is commonly chewed in many West African cultures to ease hunger pangs and sometimes for their stimulant and euphoriant qualities.
6p
vimax2711
27-03-2020
12
1
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Pharmacokinetic drug–drug interactions (in particular at metabolism) may result in fatal adverse effects in some cases. This basic information, therefore, is needed for drug therapy even in veterinary medicine, as multidrug therapy is not rare in canines and felines. The aim of this review was focused on possible drug–drug interactions in dogs and cats. The interaction includes enzyme induction by phenobarbital, enzyme inhibition by ketoconazole and flu- oroquinolones, and down-regulation of enzymes by dexamethasone.
10p
trinhthamhodang1
16-11-2019
15
0
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(bq) part 1 book "illustrated pharmacology for nurses" presentation of content: drug development, regulation and management of drug therapy and drug errors, classification and nomenclature of drugs, pharmacodynamics of drugs, pharmacokinetics of drugs,... and other contents.
107p
thangnamvoiva23
06-10-2016
42
5
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Hypertension and Chronic Kidney Disease: Cause and Consequence – Therapeutic Considerations 45 Elsa Morgado and Pedro Leão Neves Potassium-Sparing Diuretics in Hypertension 67 Cristiana Catena, GianLuca Colussi and Leonardo A. Sechi Hypertension and Renin-Angiotensin System Roberto de Barros Silva Pharmacokinetic Interactions of Antihypertensive Drugs with Citrus Juices 95 Yoshihiro Uesawa Drug Interaction
160p
xumxaxumxit
13-04-2013
63
3
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Pharmacokinetics of epinephrine in patients with septic shock: modelization and interaction with endogenous neurohormonal status...
8p
coxanh_6
29-10-2011
42
2
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models
15p
toshiba17
28-10-2011
43
2
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Pharmacokinetic Interactions Causing Decreased Drug Effects Gastrointestinal absorption can be reduced if a drug interaction results in drug binding in the gut, as with aluminum-containing antacids, kaolin-pectin suspensions, or bile acid sequestrants. Drugs such as histamine H 2 receptor antagonists or proton pump inhibitors that alter gastric pH may decrease the solubility and hence absorption of weak bases such as ketoconazole.
5p
tubreakdance
26-11-2010
82
3
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