Pharmacokinetic principles

This reference provides a concise overview of the key principles in dose selection and optimization and demonstrates applicability to recent successful new drug applications. Compiling key issues and current research on safety, efficacy, and clinical pharmacology, and PK-PD, this volume critically highlights the multidisciplinary nature of drug development and spans the fields of pharmacokinetics, clinical pharmacology, biostatistics, and experimental medicine.

301p vimeyers 29-05-2024 2 2   Download

Part 1 book "Anaesthesia science" includes content: Pharmacokinetic principles, pharmacodynamics, pharmacogenomics, receptors and second messenger systems, anaphylaxis, reflections on chirality, ion channels, immunosuppression, use and abuse of antibiotics, inflammation and immunity.

208p zizaybay1101 30-04-2024 3 2   Download

Part 1 book "Drug delivery - Engineering principles for drug therapy" includes content: Introduction, drug administration and drug effectiveness, diffusion and drug dispersion, diffusion in biological systems, drug permeation through biological barriers, drug transport by fluid motion, pharmacokinetics of drug distribution.

209p muasambanhan09 12-03-2024 4 0   Download

Part 1 book "Rang and Dale's pharmacology" includes content: How drugs act, how drugs act, how drugs act, how drugs act, cell proliferation, apoptosis, repair and regeneration, cellular mechanisms, method and measurement in pharmacology, absorption and distribution of drugs, drug metabolism and elimination, pharmacokinetics, individual variation, pharmacogenomics and personalised medicine,... and other contents.

413p muasambanhan05 22-01-2024 3 2   Download

Part 1 book "Small animal clinical pharmacology and therapeutics" includes content: Principles of clinical pharmacology, clinical pharmacokinetics, adverse drug reactions, the pharmacology of the autonomic nervous system, anesthetic agents, behavior-modifying drugs, antibacterial drugs, systemic antifungal therapy, antiparasitic drugs,.... and other contents.

484p muasambanhan03 25-12-2023 2 1   Download

Part 1 book "Small animal clinical pharmacology" includes content: Principles of clinical pharmacology, clinical pharmacokinetics, adverse drug reactions, the pharmacology of the autonomic nervous system, anesthetic agents, sedatives, behavior modifying drugs, antibacterial drugs, systemic antifungal therapy, antiparasitic drugs, glucocorticosteroids and antihistamines, immunomodulatory therapy.

291p muasambanhan03 25-12-2023 4 1   Download

Part 1 book "Controlled release veterinary drug delivery, biological and pharmaceutical considerations" includes content: Utilization of biopharmaceutical and pharmacokinetic principles in the development of veterinary controlled release drug delivery systems; intraruminal controlled release bolusesl, design parameters for post-ruminal drug delivery systems and rumen-stable products,.... and other contents.

205p oursky06 17-10-2023 2 1   Download

Part 1 book "Comparative pharmacokinetics - Principles, techniques and applications" includes content: Introduction, principles of drug movement in the body, principles of drug movement in the body, absorption, distribution, renal elimination, hepatic biotransformation and biliary excretion, compartmental models, noncompartmental models.

208p oursky05 20-09-2023 5 1   Download

Part 1 book "Comparative pharmacokinetics - Principles, techniques and applications" includes content: Nonlinear models, physiological models, physiological models, simultaneous pharmacokinetic–pharmacodynamic modeling, study design and data analysis, bioequivalence studies, population pharmacokinetic models, population pharmacokinetic models, interspecies extrapolations, interspecies extrapolations.

234p oursky05 20-09-2023 6 1   Download

Part 1 book "Strategies for reducing drug and chemical residues in food animals - International approaches to residue avoidance, management, and testing" includes content: Importance of veterinary drug residues, pharmacokinetic principles for understanding drug depletion as a basis for determination of withdrawal periods for animal drugs, evaluation of drug residue depletion in the edible products of food producing animals for establishing withdrawal periods and milk discard times,... and other contents.

150p oursky05 20-09-2023 3 1   Download

Part 1 book "Fundamentals of pharmacology for veterinary technicians" includes content: A brief history of veterinary pharmacology; veterinary drug development and control principles and methods of drug administration, pharmacokinetics, systems of measurement in veterinary pharmacology, veterinary drug use, prescribing, acquisition, and pharmacy management, drugs affecting the nervous system,... and other contents.

475p oursky05 20-09-2023 3 2   Download

(BQ) Part 1 of the document Essentials of pharmacology for anesthesia, pain medicine and critical care presents the following contents: Pharmacokinetics and pharmacodynamics of anesthetics, principles of total intravenous anesthesia, perioperative considerations in pharmacology, anesthetic induction agents, benzodiazepines and muscle relaxants,...

372p thangnamvoiva4 01-07-2016 38 3   Download

Several years ago we noted a paucity of textbooks that dealt with the principles of pharmacology as a science rather than pharmacology as a therapeutic entity. In an attempt to remedy this we organized a textbook designed to meet the needs of students interested in pharmacology at the advanced undergraduate and early graduate level. This text addresses the many facets that form the foundation of pharmacology. Students will find extensive discussions by leaders in the field are written in clear and straightforward manner.

0p mnemosyne75 02-02-2013 39 4   Download

Five years have passed since the first edition of Principles of Clinical Pharmacology was published. The second edition remains focused on the principles underlying the clinical use and contemporary development of pharmaceuticals. However, recent advances in the areas of pharmacogenetics, membrane transport, and biotechnology and in our understanding of the pathways of drug metabolism, mechanisms of enzyme induction, and adverse drug reactions have warranted the preparation of this new edition.

568p mnemosyne75 02-02-2013 72 20   Download

Principles of Antibacterial Chemotherapy The choice of an antibacterial compound for a particular patient and a specific infection involves more than just a knowledge of the agent's pharmacokinetic profile and in vitro activity.

9p colgate_colgate 21-12-2010 80 4   Download

Pharmacokinetic Interactions Causing Decreased Drug Effects Gastrointestinal absorption can be reduced if a drug interaction results in drug binding in the gut, as with aluminum-containing antacids, kaolin-pectin suspensions, or bile acid sequestrants. Drugs such as histamine H 2 receptor antagonists or proton pump inhibitors that alter gastric pH may decrease the solubility and hence absorption of weak bases such as ketoconazole.

5p tubreakdance 26-11-2010 82 3   Download

Principles of Genetic Variation and Human Traits (See also Chaps. 62 and 64) Variants in the human genome resulting in variation in level of expression or function of molecules important for pharmacokinetics and pharmacodynamics are increasingly recognized. These may be mutations (very rare variants, often associated with disease) or polymorphisms, variants that are much more common in a population. Variants may occur at a single nucleotide [known as single nucleotide polymorphism (SNP)] or involve insertion or deletion of one or more nucleotides.

6p tubreakdance 26-11-2010 110 5   Download

Principles of Pharmacokinetics The processes of absorption, distribution, metabolism, and excretion— collectively termed drug disposition—determine the concentration of drug delivered to target effector molecules. Absorption Bioavailability When a drug is administered orally, subcutaneously, intramuscularly, rectally, sublingually, or directly into desired sites of action, the amount of drug actually entering the systemic circulation may be less than with the intravenous route (Fig. 5-2A ).

8p tubreakdance 26-11-2010 107 6   Download