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Phase 2 study
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In patients with previously treated RAS-mutated microsatellite-stable (MSS) metastatic colorectal cancer (mCRC), a multicenter open-label phase 1b/2 trial was conducted to define the safety and efficacy of the MEK1/MEK2 inhibitor binimetinib in combination with the immune checkpoint inhibitor (ICI) nivolumab (anti–PD-1) or nivolumab and another ICI, ipilimumab (anti-CTLA4).
10p
vishanshan
27-06-2024
3
1
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Dose-escalated radiotherapy is known to improve progression free survival in patients with localized prostate cancer, and recent advances have led to the standardization of ultrahypofractionated stereotactic ablative radiotherapy (SABR) delivered in just 5-fractions. This study aims to evaluate the safety, efficacy, and non-inferiority of generalizable 2-fraction SABR compared to the current 5-fraction regimen.
10p
vishanshan
27-06-2024
1
1
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Advanced pancreatic cancer is one of the leading causes of cancer-related deaths. This prospective study aims to evaluate whether the addition of antibiotics improves the treatment efficacy of GEM/nabPTX as a first-line chemotherapy in patients with advanced pancreatic cancer.
8p
vikoch
27-06-2024
1
1
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Part 2 book "Electrical studies for trades" includes content: Three phase circuits, transformers, electrical services, general wiring practices part 1—receptacle and switch connections, general wiring practices part 2—protection circuits, dimmers, and chimes, three phase motors, single phase motors, schematics and wiring diagrams, motor installation.
302p
dianmotminh01
20-05-2024
5
4
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This study presents thermodynamic approaches for selecting a hydrate former suitable for water treatment. Here, carbon dioxide (CO2) and 1,1,1,2-tetrafluoroethane (HFC-134a) were investigated as hydrate formers. Simulated studies of the hydrate formation by four formers were conducted at different NaCl concentrations (0.00, 1.75, and 3.50 wt%) to predict the phase-equilibrium conditions.
5p
dianmotminh02
03-05-2024
1
1
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In this study, an evaluation of the enantioselective of a chiral flavanone with 2'-OH substitution (5,7,2'- trihydroxyflavanone) on ring C was studied by high performance liquid chromatography using the cellulose tris(3,5- dimethylphenyl carbamate)-based stationary phase with n-hexane and iso-propanol doped with 0.1% (v/v) trifluoroacetic acid as a mobile phase.
6p
dianmotminh02
03-05-2024
1
1
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Effect of substituent (Y), including halogen (F and Cl), electron donating (ED) and electron withdrawing (EW) group on the thermoparameters and kinetic behavior of reactions between 4Y-ArNH2 and CH3OO was computationally studied using density functional theory (DFT) at M05-2X/6-311++G(d,p) method in combination with the transition state theory (TST) in Eyringpy program.
7p
dianmotminh02
03-05-2024
3
1
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The geometries and relative stabilities of 15 tautomeric forms and the corresponding isomers of the studied molecules have been identified and their relative stabilities are investigated. The potential energy profiles and intrinsic reaction coordinates (IRC) calculations along the proton transfer coordinates both in the ground and in the excited state are monitored as well. The impact of the donating (OMe) and withdrawing (NO2) groups on the single and double proton transfers are investigated both in the gas phase and solution.
9p
dianmotminh02
03-05-2024
4
1
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. In vitro biological evaluation revealed the most active compound 4d with an inhibitory concentration of 42.87 μM against K562 and 47.42 μM on A549 cells. The anticancer activity of this naphthylidene isoxazolidinedione derivative was evident by cell cycle and apoptosis assays, which showed arrest of the G2/M phase (65.6%) of the K562 cells and induction of apoptosis with 21.47% apoptotic cells as compared to 0.2% of untreated cells, respectively.
10p
dianmotminh02
03-05-2024
2
2
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Part 2 book "Electrical studies for trades" includes content: Three phase circuits; transformers; three phase transformers; electrical services; general wiring practices receptacle and switch connections; general wiring practices; protection circuits, dimmers and chimes; three phase motors; single phase motors; schematics and wiring diagrams; motor installation.
357p
dianmotminh00
22-04-2024
3
2
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A limited number of studies have characterized genomic properties of hepatocellular carcinoma (HCC) patients in response to anti-PD-1 immunotherapy. Methods: Herein, we performed comprehensive molecular characterization of immediate (D-42 to D-1) pretreatment tumor biopsy specimens from 60 patients with sorafenib-failed HCC in a single-arm prospective phase II trial of pembrolizumab.
15p
vibransone
28-03-2024
4
2
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The thesis "Stability of some classes of degenerate two-phase difference systems with delay" is to study the stability of degenerate two-phase systems with mixed delay in the direction of variation; Stability and dissipation in finite domain of degenerate 2-D system with variable delay; Evaluation of the gain set and control design for a degenerate 2-D system in the Roesser model with variable delay;... Please refer to it!
120p
gaupanda019
21-03-2024
4
1
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Assess the total energy needs during the general and professional preparation phases (total energy consumption) for national athletic athletes and swimmers. Cross-sectional descriptive study with analysis. This research evaluates the Total Energy Expenditure (TTEE) in track and field athletes participating in sprints, jumps, and throw events (2 men, 3 women), as well as swimmers specializing in sprint and medium-length events (3 men, 2 women) in Ho Chi Minh City National Sports Training Center in February 2023.
6p
vimichaelfaraday
28-12-2023
5
3
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Concurrent chemoradiotherapy (CCRT) is a standard treatment choice for locally advanced hypopharyngeal carcinoma. The aim of this study was to investigate whether induction chemotherapy (IC) followed by CCRT is superior to CCRT alone to treat locally advanced hypopharyngeal carcinoma.
10p
vileonardodavinci
23-12-2023
2
2
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The non-inferiority of dexamethasone (DEX) on day 1, with or without low-dose DEX on days 2 and 3, combined with oral NEPA (netupitant/palonosetron), compared with the guideline-consistent use of DEX was demonstrated in cisplatin. Here, we complete the analysis by assessing the impact of emesis on daily lives of patients receiving DEX-sparing regimens using the Functional Living Index-Emesis (FLIE).
8p
vialfrednobel
23-12-2023
3
3
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Tregs are able of suppressing tumor-specific efector cells, such as lymphocytes CD8+, CD4+ and Natural Killer cells. Different drugs, especially different schedules of administration, like metronomic chemotherapy (mCHT), seem to be able to increase anticancer immunity, by acting on downregulation of Tregs.
10p
vialfrednobel
23-12-2023
5
3
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Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) comprise several rare hematologic malignancies with shared concomitant dysplastic and proliferative clinicopathologic features of bone marrow failure and propensity of acute leukemic transformation, and have significant impact on patient quality of life.
15p
vialfrednobel
23-12-2023
6
4
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Ibrutinib, a first-in-class inhibitor of Bruton’s tyrosine kinase, is approved for the treatment of various B-cell malignancies and chronic graft-versus-host disease. Based on encouraging preclinical data, safety and efcacy of ibrutinib combined with companion drugs for advanced renal cell carcinoma (RCC), gastric/gastroesophageal junctional adenocarcinoma (GC), and colorectal adenocarcinoma (CRC) were evaluated.
14p
vialfrednobel
23-12-2023
3
3
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The mammalian target of rapamycin (mTOR) kinase, a central component of the PI3K/AKT/mTOR pathway, plays a critical role in tumor biology as an attractive therapeutic target. We conducted this first-in-human study to investigate the safety, pharmacokinetics (PK), and pilot efficacy of LXI-15029, an mTORC1/2 dual inhibitor, in Chinese patients with advanced malignant solid tumors.
12p
vialfrednobel
23-12-2023
2
2
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The main objective of this study is to perform a numerical investigation of flow inside a small cyclone separator. The steady state of the governing equations is solved by using Ansys Fluent 19.2 software.
10p
vijeff
27-11-2023
8
4
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