Phase disposition

In present experiment, Pharmacokinetic study of isoniazid (INH) was investigated in cow calf by using reverse phase high performance liquid chromatography (RP-HPLC) method. The determination INH was carried out after oral and intravenous administration in cow calves at a dose of 25 mg/kg body weight orally and 10mg/kg body weight intravenously.

9p trinhthamhodang1216 19-11-2020 10 1   Download

The objective of this work was to establish the quantitative relationship between Lanreotide Autogel® (LAN) on serum chromogranin A (CgA) and progression-free survival (PFS) in patients with nonfunctioning gastroenteropancreatic neuroendocrine tumors (GEP-NETs) through an integrated pharmacokinetic/pharmacodynamic (PK/PD) model. In CLARINET, a phase III, randomized, doubleblind, placebo-controlled study, 204 patients received deep subcutaneous injections of LAN 120 mg (n = 101) or placebo (n = 103) every 4 weeks for 96 weeks.

10p caothientrangnguyen 09-05-2020 15 0   Download

The liquid chromatography–tandem mass spectrometric assay method for the simultaneous determination of rosuvastatin and amlodipine in human plasma using deuterated analogs as internal standards has been developed and validated. The analytes were extracted from 100 lL aliquots of human plasma via liquid–liquid extraction using a mixture of ethyl acetate and n-hexane (80:20, v/v) as an extraction solvent. The optimized mobile phase was composed of 0.1% formic acid in 5 mM ammonium acetate, methanol, and acetonitrile (20:20:60, v/v/v) and delivered at a flow rate of 0.75 mL/min.

10p trinhthamhodang1 16-11-2019 28 1   Download

Vienna rectifier with reduced number of switches has been receiving wide interest in the past years to improve the input power quality of rectifier systems. In this paper, a review of three phase 3-level Vienna and configuration of 5-level structure from 3-level Vienna topology are presented.

4p vicapital2711 02-08-2019 9 1   Download

Information disposition and sanitization decisions occur throughout the system life cycle. Critical factors affecting information disposition and media sanitization are decided at the start of a system’s development. The initial system requirements should include hardware and software specifications as well as interconnections and data flow documents that will assist the system owner in identifying the types of media used in the system.

32p thamgiacongdong 02-05-2013 50 5   Download