Phase solubility
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Ebook "Citric acid" is devoted to different aspects associated with citric acid, inorganic citrates and their aqueous and organic solutions. It includes information about properties, occurrence and technological applications of citric acid and inorganic citrates. Phase equilibria - melting, freezing, boiling, vapour pressures, solubilities of citric acid in water, organic solvents and ternary systems are presented, correlated, and analyzed.
365p tudohanhtau1006 29-03-2024 1 1 Download
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Lipophilicity can be measured with different methods, such as Shake-Flask or liquid chromatography. HPLC presents the advantage of overcoming solubility issues and therefore extending the range of lipophilicity to high values.
11p vironald 15-12-2022 8 2 Download
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The flexible and reversible preparation of columns for use in high-performance solid phase extraction chromatography by physisorption of organophosphorus acid extractants has been investigated in detail.
9p vironald 15-12-2022 5 2 Download
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Org 25435 is a new water-soluble alpha-amino acid ester intravenous anaesthetic which proved satisfactory in animal studies. This study aimed to assess the safety, tolerability and efficacy of Org 25435 and to obtain preliminary pharmacodynamic and pharmacokinetic data.
11p viisaacnewton 26-04-2022 11 1 Download
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In this study, colloidal CdS quantum dots were synthesized, structurally characterized, and their effect on performance of perovskite solar cells was observed by using them as interface modification agent between TiO2 /perovskite. Colloidal CdS quantum dots were synthesized based on two-phase method and characterized by X-ray diffraction and Transmission Electron Microscopy techniques. The average particle size of CdS quantum dots have found to be around 5 nm. Oleic acid was used as capping agent during synthesis to lead solubility in organic solvents.
7p langthannam 29-12-2021 20 1 Download
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Lecture Physical chemistry: Phase diagrams and phase rule provide students with knowledge about introduction, solubility limits, phase equilibrium, interpretation of phase diagrams, binary isomorphous systems (Cu-Ni), development of microstructure, mechanical properties, binary eutectic systems, development of eutectic alloy microstructure,...
48p bachnhuocdong 23-12-2021 17 0 Download
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This review discusses about functional characterization like interfacial properties, gelation, and phase separation behavior of egg yolk and its constituents (plasma and granules). This reviews briefly discuss about constituent characterization like xanthophylls, color stability, fatty composition with using newer analysis techniques. Besides, its applications in different industries like bakery, snacks, meat industry and production of nanogels have also been documented.
7p mudbound 10-12-2021 11 0 Download
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The affinity of irbesartan (IRB) to form inclusion complexes with β-cyclodextrin (β-CD), hydroxypropylβ-cyclodextrin (HP-β -CD), and γ-cyclodextrin (γ-CD) was investigated in aqueous buffered solutions at pH 1.7, 4.1, and 7.0. Analysis of the UV absorption-pH profiles revealed that IRB has two pKa values: pKa1 = 3.60 (imidazolinone ring moiety) and pKa2 = 4.70 (tetrazole moiety). In the presence of 5.0 mmol L−1β-CD, the tetrazole moiety became more acidic, indicating its inclusion within the β-CD cavity.
15p tudichquannguyet 29-11-2021 17 0 Download
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A reversed-phase high-performance liquid chromatographic method has been developed for the simultaneous quantitation of water-soluble vitamins like ascorbic acid (C), thiamine (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), pyridoxine (B6) and folic acid (B9) in five potent wild edible fruits named Morus indica, Meynalaxi flora, Solanum gilo, Solanum kurzii and Viburnum foetidum, consumed by the tribal people of North-eastern region in India.
14p gaocaolon9 22-12-2020 17 2 Download
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he effect of the ZnO addition in pure perovskite PZT−PMnN−PSbN ceramics sintered from 950 to 1200oC has been investigated. The phase structure of ceramics changes from rhombohedral to tetragonal and the temperature decreases with the increase of the ZnO content. The limitation of Zn2+ concentration for the solubility in PZT–PMnN–PSbN systems is about 0.25% wt., at which the ceramic shows some good physical properties such as the density of 8.20 g/cm3 , some dielectric constants including εr = 1,555 and εmax = 32,900.
9p nguaconbaynhay9 03-12-2020 7 0 Download
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A Phase I dose escalation first in man study assessed maximum tolerated dose (MTD), dose-limiting toxicity (DLT) and recommended Phase II dose of TP300, a water soluble prodrug of the Topo-1 inhibitor TP3076, and active metabolite, TP3011.
10p vijisoo2711 30-09-2020 11 1 Download
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The purpose of this study was to improve the aqueous solubility, dissolution, and pharmacodynamic properties of a BCS class II drug, ezetimibe (Eze) by preparing ternary cyclodextrin complex systems. We investigated the potential synergistic effect of two novel hydrophilic auxiliary substances, D-αtocopheryl polyethylene glycol 1000 succinate (TPGS) and L-ascorbic acid-2-glucoside (AA2G) on hydroxypropyl-β-cyclodextrin (HPBCD) solubilization of poorly water-soluble hypocholesterolemic drug, Eze.
12p caothientrangnguyen 09-05-2020 11 1 Download
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To improve the solubility and oral bioavailability of erlotinib, a poorly water-soluble anticancer drug, solid self-emulsifying drug delivery system (SEDDS) was developed using solid inert carriers such as dextran 40 and Aerosil® 200 (colloidal silica). The preliminary solubility of erlotinib in various oils, surfactants, and co-surfactants was determined. Labrafil M2125CS, Labrasol, and Transcutol HP were chosen as the oil, surfactant, and co-surfactant, respectively, for preparation of the SEDDS formulations. The ternary phase diagram was evaluated to show the self-emulsifying area.
8p caothientrangnguyen 09-05-2020 13 1 Download
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Drug–polymer miscibility is one of the fundamental prerequisite for the successful design and development of amorphous solid dispersion formulation. The purpose of the present work is to provide an example of the theoretical estimation of drug–polymer miscibility and solubility on the basis of Flory– Huggins (F–H) theory and experimental validation of the phase diagram.
10p caothientrangnguyen 09-05-2020 10 0 Download
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Viscous aqueous solutions of chitosan and polyvinyl alcohol (PVA) were blended to enhance miscibility and avoid polymer phase separation. The mixtures were drop-casted and air dried to yield composite film materials that were characterized by equilibrium water uptake, physical stability in aqueous solution, and thermal stability. Chitosan/PVA blends have greater thermal stability, unique morphology, and reduced solubility in acidic solution, thus extending the useful pH range for chitosan as a sorbent material.
7p mentospurefresh 29-11-2019 34 3 Download
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BCS class III drugs suffer from a drawback of low permeability even though they have high aqueous solubility. The objective of current work was to screen the suitability of glyceryl monooleate (GMO)/Pluronic F127 cubic phase liquid crystals precursors for permeation enhancement and in turn the bioavailability of tenofovir disoproxil fumarate (TDF), a BCS class III drug. Spray-drying method was used for preparation of TDF loaded liquid crystal precursors (LCP) consisting of GMO/Pluronic F127 and lactose monohydrate with an ability to in situ transform into stable cubic phases upon hydration.
10p trinhthamhodang1 14-11-2019 13 0 Download
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The decrease in strength of tile adhesive mortars during wet storage was investigated. In a first approach, the water resistance of the polymer phases was tested on structures isolated from the mortar and in situ. It was observed that cellulose ether and polyvinyl alcohol structures are water-soluble. Subsequent investigations on polymer mobility within the mortar showed that the migrating pore water transports cellulose ether and polyvinyl alcohol during periods of water intrusion and drying. This leads to enrichments at the mortar – substrate interface.
12p christian2605 11-10-2019 20 0 Download
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Fe3O4 magnetic nanoparticles were synthesized by hydrothermal and thermal decomposition methods. Particles synthesized by hydrothermal method were water soluble meanwhile one by thermal decomposition method were organic soluble. Structure, morphology and magnetic properties of magnetic powders and magnetic fluid samples were characterized.
6p vimessi2711 02-04-2019 23 0 Download
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The results show that the HAp/fCNTs nanocomposite coatings contain single phase of HAp and CNTs with the coating thickness of 6.9 µm and the amount of fCNTs in the coatings is 6.95 %. With the presence of fCNTs in HAp coatings, the solubility of the coatings decreases in comparision with pure HAp coatings.
10p cumeo3000 01-08-2018 33 0 Download
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Study on the impact of temperature on the gene expression showed that TrxFljB was synthesized at lower level at 37oC comparing to the levels at 22oC and 25oC. 13% of the protein synthesized at 37oC was inclusion body. Lower temperatures used during induction phase increased the solubility of the recombinant protein. About 97% of TrxFljB synthesized at 25oC was soluble.
9p jangni2 19-04-2018 35 2 Download