Photoaffinity probes

Ebook "Development of novel anti-HIV pyrimidobenzothiazine derivatives" is in three parts. The first part expounds efficient methods for the synthesis of tricyclic heterocycles related to PD 404182 based on the sp2-carbon−heteroatom bond formations. The second part explains SAR studies of PD 404182 for the development of anti-HIV agents. The third part of the thesis elucidates the development of photoaffinity probes for the target identification of PD 404182.

157p coduathanh1122 27-03-2024 2 1   Download

In plants, GABA plays a critical role in sexual plant reproduction; however, GABA receptors and the associated detailed signaling mechanisms remain to be elucidated. Our experiments show that the proposed technique is reliable and convenient for probing GABA-binding proteins and could be applicable in similar projects by covalently immobilizing the free carboxylic group of GABA on magnetic beads (SiMAG-Carboxyl). New probes produced by covalently immobilizing the free carboxylic group of GABA on magnetic beads (SiMAG-Carboxyl) can obtain useful information on GABA receptors in plants.

10p thiencuuchu 27-11-2021 6 1   Download