Physicochemical characterization

Therefore, this study aimed to develop and characterize solid lipid nanoparticles (SLNs) containing tinidazole (TNZ-SLNs) oriented to be incorporated into the gel to increase the penetration ability and prolong drug retention time in periodontal tissues.

8p viharuno 03-01-2025 1 1   Download

Periodontitis is a chronic bacterial infection destroying tooth-supporting tissues. Like metronidazole, tinidazole (TNZ) is also effective in treating periodontitis. This study aimed to formulate and optimize TNZ nanoparticles and evaluate their physicochemical properties.

9p viharuno 03-01-2025 1 1   Download

The thesis aims to successfully fabricate NaHAp films doped separately and simultaneously with microelements: sodium, magnesium, strontium, fluorine, copper, silver and zinc on 316L stainless steel substrate to meet the requirement of screw bracing bone. Study on physicochemical characteristics, study on toxicity, antibacterial ability and bio-compatibility of NaHAp films separately and concurrently with trace elements.

27p xacxuoc4321 11-07-2019 22 3   Download

Random PCR mutagenesis was applied to theThermus thermophilus xylA gene encoding xylose isomerase. Three cold-adapted mutants were isolated with the following amino-acid substitutions: E372G, V379A (M-1021), E372G, F163L (M-1024) and E372G (M-1026). The wild-type and mutated xylAgenes were cloned and expressed in Escherichia coliHB101 using the vector pGEMÒ-T Easy, and their physicochemical and catalytic properties were determined.

7p research12 29-04-2013 54 3   Download

We report a comprehensive physicochemical characteriza-tion of a glycoglycerolipid from Mycoplasma fermentans, MfGl-II, in relation to its bioactivityand compared thiswith the respective behaviors of phosphatidylcholine (PC) and a bacterial glycolipid, lipopolysaccharide (LPS) from deep rough mutantSalmonella minnesotastrain R595. Theb«a gel-to-liquid crystalline phase transition behavior of the hydrocarbon chains withTc¼30Cfor MfGl-II as well as for LPS exhibits high similarity between the two glycolipids.

9p tumor12 20-04-2013 32 2   Download

Lipopolysaccharide (LPS) from the outer membrane of Gram-negative bac-teria belongs to the most potent activators of the mammalian immune sys-tem. Its lipid moiety, lipid A, the ‘endotoxic principle’ of LPS, carries two negatively charged phosphate groups and six acyl chain residues in a defined asymmetric distribution (corresponding to synthetic compound 506). Tetraacyl lipid A (precursor IVa or synthetic 406), which lacks the two hydroxylated acyl chains, is agonistically completely inactive, but is a strong antagonist to bioactive LPS when administered to the cells before LPS addition. .

14p awards 05-04-2013 28 2   Download

NovelN,N¢-diacyl-1,3-diaminopropyl-2-carbamoyl bivalent cationic lipids were synthesized and their physicochemical properties in lamellar assemblies with and without plasmid DNA were evaluated to elucidate the structural requirements of these double-chained pH-sensitive surfactants for potent non-viral gene delivery and expression.

15p media19 05-03-2013 39 2   Download