Physiological target sites

Ebook "Biology, physiology and molecular biology of weeds" provides comprehensive information on a wide range of topics from biology, physiology, genetics to the use of genomic tools in weed science. The book covers information at a more advanced level than the previously published books in weed science. It covers not only weed genetics and genomics research, but also weed management from an ecological perspective.

231p lamquandat 28-12-2023 12 3   Download

MicroRNA regulation is fundamentally responsible for fine-tuning the whole gene network in human and has been implicated in most physiological and pathological conditions. Studying regulatory impact of microRNA on various cellular and disease processes has resulted in numerous computational tools that investigate microRNA-mRNA interactions through the prediction of static binding site highly dependent on sequence pairing.

11p vitzuyu2711 29-09-2021 14 1   Download

Understanding the mechanisms by which transcription factors (TF) are recruited to their physiological target sites is crucial for understanding gene regulation. DNA sequence intrinsic features such as predicted binding affinity are often not very effective in predicting in vivo site occupancy and in any case could not explain cell-type specific binding events.

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Non-human primate (NHP) models can closely mimic human physiological functions and are therefore highly valuable in biomedical research. Genome editing is now developing rapidly due to the precision and efficiency offered by engineered site-specific endonuclease-based systems, such as transcription activator-like effector nucleases (TALENs) and the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPRassociated protein-9 nuclease (Cas9) system.

10p vihamax2711 21-04-2020 12 0   Download

Microdialysis is a very useful sampling tool that can be used in vivo to acquire concentration variations of protein - unbound molecules located in interstitial or extracellular spaces. This technique relies on the passive diffusion of substances across a dialysis membrane driven by a concentration gradient.

576p hotmoingay 03-01-2013 44 3   Download

The mode of action of pesticides is extremely fascinating because the subject covers so many fields of biology and chemistry and has many practical implications. All disciplines of biology have developed greatly since 1,1,1-trichloro- di-(4-chlorophenyl)ethane — better known as DDT — and the other synthetic pesticides were introduced just after the Second World War.

271p crazy_sms 10-05-2012 94 37   Download