Pilot trial
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Differentiated service delivery (DSD) programs for people living with HIV (PWH) limit eligibility to patients established on antiretroviral therapy (ART), yet uncertainty exists regarding the duration on ART necessary for newly-diagnosed PWH to be considered established. We aimed to determine the feasibility, acceptability, and preliminary impact of entry into DSD at six months after ART initiation for newly-diagnosed PWH.
10p vishanshan 27-06-2024 1 1 Download
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The promising therapeutic outcomes of neoadjuvant immunotherapy combined with chemotherapy in the treatment of locally advanced esophageal squamous cell carcinoma (ESCC) have been confirmed by several phase II clinical trials and have been widely demonstrated in clinical work.
7p vileonardodavinci 23-12-2023 3 3 Download
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Radiation therapy is one of the standard methods in the treatment of breast cancer. Radiotherapyinduced dermatitis (RID) is a common complication of radiotherapy (RT) resulting in less tolerance in RT and even discontinuation of treatment.
11p vialfrednobel 23-12-2023 4 3 Download
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The mammalian target of rapamycin (mTOR) kinase, a central component of the PI3K/AKT/mTOR pathway, plays a critical role in tumor biology as an attractive therapeutic target. We conducted this first-in-human study to investigate the safety, pharmacokinetics (PK), and pilot efficacy of LXI-15029, an mTORC1/2 dual inhibitor, in Chinese patients with advanced malignant solid tumors.
12p vialfrednobel 23-12-2023 2 2 Download
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Knee osteoarthritis (KOA) is one of the most common causes of chronic pain and disability. In addition, many studies have shown that laser acupuncture (LA) has a great analgesic effect and minimal side effects. This study aims to evaluate the efficacy and safety of LA combined with knee exercises (KE) in patients with KOA.
8p vikissinger 21-12-2023 2 2 Download
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This study explored the experiences of participation in cancer rehabilitation research during active cancer treatment. Participants were people living with haematological cancer myeloma, undergoing autologous stem cell transplantation (ASCT) recruited to the PERCEPT myeloma pilot trial.
13p vischultz 20-10-2023 3 1 Download
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Cancer patients with newly created ostomies face complications that reduce quality of life (QOL) and increase morbidity and mortality. This proof-of-concept study examined the feasibility, usability, acceptability, and initial efficacy of an eHealth program titled the “Patient Reported Outcomes-Informed Symptom Management System” (PRISMS) during post-ostomy creation care transition.
13p visharma 20-10-2023 6 3 Download
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Patients undergoing hematopoietic cell transplantation (HCT) are at high risk of chronic health complications, including frailty and physical dysfunction. Conventional exercise programs have been shown to improve frailty in other cancer populations, but these have largely been based out of rehabilitation facilities that may act as geographic and logistical barriers.
9p visharma 20-10-2023 4 2 Download
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This paper overviews three major anti-corruption legal reforms in China: the enactment of the National Supervision Law in 2018, the establishment of a specia l proceeding of confiscation of illegal gains in the 2012 Criminal Procedure Law (CPL) amendment, and the introduction of “trial in absentia” in the 2018 CPL amendment, as well as the ongoing pilot reforms on corporate compliance non-prosecution.
8p viberkshire 09-08-2023 5 5 Download
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Design and pilot test a new decision making tool for women with physical disabilities (impairment of physical function due to chronic conditions) considering pregnancy. Clinical guidelines and survey and focus group data about pregnancy informational and decisional needs guided content development. The tool was pilot tested in a 12-week trial with participants with physical disabilities considering or actively planning a pregnancy.
11p vigamora 25-05-2023 4 2 Download
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This includes group-based support delivered by trained lay local community facilitators (CFs) and free nicotine replacement therapy (NRT). The intervention was pilot tested in a cluster randomised controlled trial, ‘We Can Quit 2’. This paper reports on the WCQ2 process evaluation which assessed feasibility and acceptability of the programme and trial processes.
14p viferrari 28-11-2022 7 2 Download
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The standard of care treatment for soft tissue sarcoma of the extremities is a wide resection in combination with pre- or postoperative radiotherapy with high local control rates, sparing patients the necessity of amputation without compromising on overall survival rates.
8p vikolindagrabar 27-07-2022 5 2 Download
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In preparing novice anesthesiologists to perform their first ultrasound-guided axillary brachial plexus blockade, we hypothesized that virtual reality simulation-based training offers an additional learning benefit over standard training. We carried out pilot testing of this hypothesis using a prospective, single blind, randomized controlled trial.
10p viisaacnewton 26-04-2022 7 2 Download
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Music-based interventions (MBI), using music as a therapeutic medium, has been utilized as a promising strategy for motor relearning and shaping. However, currently, MBI with active performance training is restricted to being extensively applied for patients with various levels of defects in fine motor skills and cognitive functions.
9p vinobelprisen 26-03-2022 19 3 Download
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Early mobilization after surgery is a key recommendation for people with hip fracture, however this is achieved by only 50% of people. Recumbent bike riding has been used in other populations with limited mobility and has potential to allow early exercise in people post hip fracture.
11p vinobelprisen 26-03-2022 19 3 Download
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Inadvertent intraoperative hypothermia (core temperature < 36 °C) is a common but preventable adverse event. This study aimed to determine whether active intraoperative warming reduced bleeding in patients undergoing major operations: open thoracic surgery and hip replacement surgery.
7p vampires36 30-12-2021 7 1 Download
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Major abdominal surgery is associated with endothelial glycocalyx disruption. The anti-inflammatory effects of lidocaine were recently associated with endothelial barrier protection. Methods: This was a single-centre, parallel group, randomized, controlled, double blind, pilot trial.
10p vizhangzhidong 29-12-2021 4 0 Download
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The ultrasound guided intermediate cervical plexus block with perivascular infiltration of the internal carotid artery (PVB) is a new technique for regional anesthesia in carotid endarterectomy (CEA). We conducted a pilot study investigating the effects of deep cervical block (DCB), intermediate cervical block alone (ICB) and PVB on perioperative complications in patients undergoing elective CEA. We hypothesized, that the ropivacaine plasma concentration is higher in patients receiving DCB compared to PVB and ICB.
12p vizhangzhidong 29-12-2021 13 0 Download
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The glycocalyx layer is a key structure in the endothelium. Tourniquet-induced ischemic periods are used during orthopedic surgery, and the reactive oxygen species generated after ischemia-reperfusion may mediate the shedding of the glycocalyx.
9p vizhangzhidong 29-12-2021 11 1 Download
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The incidence of acute kidney injury (AKI) remains high after partial nephrectomy. Ischemiareperfusion injury produced by renal hilum clamping during surgery might have contributed to the development of AKI. In this study we tested the hypothesis that goal-directed fluid and blood pressure management may reduce AKI in patients following partial nephrectomy.
10p vidietmarhopp 28-12-2021 7 0 Download