Planar cell polarity

Adenovirus protein, Gam1, triggers the proteolytic destruction of the E1 SUMO-activating enzyme. Microinjection of an empirically determined amount of Gam1 mRNA into one-cell Xenopus embryos can reduce SUMOylation activity to undetectable, but nonlethal, levels, enabling an examination of the role of this posttranslational modification during early vertebrate development.

19p visilicon2711 20-08-2021 7 1   Download

Cells in some tissues acquire a polarisation in the plane of the tissue in addition to apical-basal polarity. This polarisation is commonly known as planar cell polarity and has been found to be important in developmental processes, as planar polarity is required to define the in-plane tissue coordinate system at the cellular level.

17p vimariana2711 22-12-2020 11 0   Download

Changes in transcellular bioelectrical patterns are known to play important roles during developmental and regenerative processes. The Drosophila follicular epithelium has proven to be an appropriate model system for studying the mechanisms by which bioelectrical signals emerge and act.

17p viwyoming2711 16-12-2020 13 1   Download

WNT signaling pathways are significantly altered during cancer development. Vertebrates possess two classes of WNT signaling pathways: the “canonical” WNT/β-catenin signaling pathway, and the “non-canonical” pathways including WNT/Ca2+ and WNT/Planar cell polarity [PCP] signaling.

14p vijennie2711 29-09-2020 13 1   Download

MLK3 gene mutations were described to occur in about 20% of microsatellite unstable gastrointestinal cancers and to harbor oncogenic activity. In particular, mutation P252H, located in the kinase domain, was found to have a strong transforming potential, and to promote the growth of highly invasive tumors when subcutaneously injected in nude mice.

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The non-canonical Wnt/Planar cell polarity (PCP) signaling pathway is a major player in cell migration during embryonal development and has recently been implicated in tumorigenesis. Our experimental data demonstrate that high expression of Prickle1 and Vangl2 reduce the growth of neuroblastoma cells and indicate different roles of PCP proteins in tumorigenic cells compared to normal cells.

14p vinaypyidaw2711 26-08-2020 10 2   Download

Hair follicles display periodic growth. Wnt signaling is a critical regulator for hair follicle regeneration. Previously, we reported that Wnt5a inhibits the telogen-to-anagen transition of hair follicles, but the mechanism by which this process occurs has not yet been reported.

8p viwashington2711 04-12-2019 12 1   Download

The Wnt signaling pathway is evolutionary conserved and controls many biological processes like cell proliferation and differentiation. It also provides planar polarity, regulation of the cell cycle, and cell adhesion during both the embryonic and adult period.

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The formation of properly differentiated organs often requires the planar coordination of cell polarization within the tissues. Such planar cell polar-ization (PCP) events are best studied in Drosophila, where many of the key players, known as PCP genes, have already been identified. Genetic analy-sis of the PCP genes suggests that the establishment of polarity consists of three major steps.

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Roles of planar cell polarity pathways in the development of neutral tube defects...

10p toshiba23 21-11-2011 40 3   Download