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Plasma medicine
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For the majority of rare clinical missense variants, pathogenicity status cannot currently be classified. Classical homocystinuria, characterized by elevated homocysteine in plasma and urine, is caused by variants in the cystathionine beta-synthase (CBS) gene, most of which are rare. With early detection, existing therapies are highly effective.
18p
vibransone
28-03-2024
5
2
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Cell-free tumor-derived DNA (ctDNA) allows non-invasive monitoring of cancers, but its utility in renal cell cancer (RCC) has not been established. Methods: Here, a combination of untargeted and targeted sequencing methods, applied to two independent cohorts of patients (n = 91) with various renal tumor subtypes, were used to determine ctDNA content in plasma and urine.
17p
vibransone
28-03-2024
4
2
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Accurate lung cancer classification is crucial to guide therapeutic decisions. However, histological subtyping by pathologists requires tumor tissue—a necessity that is often intrinsically associated with procedural difficulties. The analysis of circulating tumor DNA present in minimal-invasive blood samples, referred to as liquid biopsies, could therefore emerge as an attractive alternative.
12p
vibransone
28-03-2024
6
2
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The human plasma proteome is important for many biological processes and targets for diagnostics and therapy. It is therefore of great interest to understand the interplay of genetic and environmental factors to determine the specific protein levels in individuals and to gain a deeper insight of the importance of genetic architecture related to the individual variability of plasma levels of proteins during adult life.
16p
vibransone
28-03-2024
5
2
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DNA originating from degenerate tumour cells can be detected in the circulation in many tumour types, where it can be used as a marker of disease burden as well as to monitor treatment response. Although circulating tumour DNA (ctDNA) measurement has prognostic/predictive value in metastatic prostate cancer, its utility in localised disease is unknown.
11p
vibransone
28-03-2024
3
2
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In the present study, we investigated the expression profile of tDRs in plasma of CRC patients. The results showed that the level of 5′-tRF-GlyGCC is higher in CRC patients than in healthy controls (HCs) and highlighted that 5′- tRF-GlyGCC is a promising diagnostic biomarker for CRC patients. Its expression is positively correlated with ALKBH3 both in vitro and in vivo, respectively.
12p
vibransone
28-03-2024
2
2
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Cell-free DNA (cfDNA) profiling is increasingly used to guide cancer care, yet mutations are not always identified. The ability to detect somatic mutations in plasma depends on both assay sensitivity and the fraction of circulating DNA in plasma that is tumor-derived (i.e., cfDNA tumor fraction).
15p
vibransone
28-03-2024
3
2
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Blood plasma proteins play an important role in immune defense against pathogens, including cytokine signaling, the complement system, and the acute-phase response. Recent large-scale studies have reported genetic (i.e., protein quantitative trait loci, pQTLs) and non-genetic factors, such as age and sex, as major determinants to inter-individual variability in immune response variation.
15p
viellison
28-03-2024
3
2
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The proteome is a major source of therapeutic targets. We conducted a proteome-wide Mendelian randomization (MR) study to identify candidate protein markers and therapeutic targets for colorectal cancer (CRC).
13p
vicwell
29-02-2024
2
1
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Ebook "Crossroads between innate and adaptive immunity IV (Advances in experimental medicine and biology, Volume 785)" presents a collection of reviews derived from work presented at the Aegean Conference: “4th Crossroads between innate and adaptive immunity”. This meeting was the fourth in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen presentation and adaptive immunity.
144p
duongthandue0501
28-02-2024
1
1
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The fine-scale cell-free DNA fragmentation patterns in early-stage cancers are poorly understood. We developed a de novo approach to characterize the cell-free DNA fragmentation hotspots from plasma whole-genome sequencing.
15p
vicwell
29-02-2024
2
1
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Human proteins are widely used as drug targets. Integration of large-scale protein-level genome-wide association studies (GWAS) and disease-related GWAS has thus connected genetic variation to disease mechanisms via protein. Previous proteome-by-phenome-wide Mendelian randomization (MR) studies have been mainly focused on plasma proteomes.
22p
vicwell
29-02-2024
3
1
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Part 1 book "Veterinary surgery - Small animal" includes content: Inflammatory response, stem cells and regenerative medicine, platelet rich plasma and autologous conditioned sera, fluid therapy, shock, bleeding and hemostasis, metabolism and nutritional needs of surgical patients, wound healing, wound infections and antimicrobial use, the operating room, monitoring for surgical infection.... and other contents.
465p
muasambanhan05
16-01-2024
5
0
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Part 2 book "Wavelets in physics" includes content: Wavelets and detection of coherent structures in fluid turbulence; wavelets, non linearity and turbulence in fusion plasmas; transfers and fluxes of wind kinetic energy between orthogonal wavelet components during atmospheric blocking; wavelets in atomic physics and in solid state physics; the thermodynamics of fractals revisited with wavelets; wavelets in medicine and physiology; wavelet dimensions and time evolution.
254p
muasambanhan05
22-01-2024
4
2
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Methotrexate (MTX) is a chemotherapy and immunosuppressive agent widely used to treat cancer, autoimmune diseases in children and adult patients, and ectopic pregnancy. However, MTX is highly toxic to the liver, kidney, and nervous system. This study aimed to quantify the concentration of MTX in human plasma using high-performance liquid chromatography (HPLC).
6p
vikissinger
21-12-2023
1
1
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Several generic products containing simvastatin are circulating on the Vietnamese market at a more inexpensive price than that of a brand-name one. These formulations, however, have not been assessed for in vivo bioequivalence to the reference product.
9p
vikissinger
21-12-2023
2
1
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Tenofovir alafenamide (TAF), a prodrug of tenofovir (TFV), is currently used for treatment of chronic hepatitis B as first line recommendation. This study has been performed with the aim of development, validation, and application of LC-MS/MS procedure for quantitation of TAF and TFV in human plasma.
10p
vikissinger
21-12-2023
3
1
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Part 1 book "Manual of veterinary transfusion medicine and blood banking" includes content: Evolution of veterinary transfusion medicine and blood banking, component therapy, red blood cell products, plasma products, platelet products, hemoglobin based oxygen carrier solutions, alternative plasma protein products: albumin and human immunoglobulin therapy,... and other contents.
200p
muasambanhan01
13-12-2023
6
3
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Part 1 book "Veterinary laboratory medicine" includes content: The red blood cells (erythrocytes), the platelets (thrombocytes) and the coagulation factors, the white blood cells (leucocytes), the plasma proteins, the electrolytes, the minerals, the nitrogenous substances, carbohydrate metabolism, bilirubin and fat metabolism, clinical enzymology, plasma enzymes in diagnosis I-I diagnostic endocrinology, non blood body fluids, feline virus testing.
214p
oursky07
24-10-2023
6
3
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Part 1 of ebook "Veterinary laboratory medicine: Clinical biochemistry and haematology" provides readers with content including: haematology; the red blood cells (erythrocytes); the platelets (thrombocytes) and the coagulation factors; the white blood cells (leucocytes); clinical biochemistry; the plasma proteins; the nitrogenous substances; clinical enzymology - plasma enzymes in diagnosis; diagnostic endocrinology; non-blood body fluids;...
203p
lytamnguyet
04-08-2023
6
3
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