Platinum complexes

Many experimental data show that bulky substituents on the molecules enhance solubility, catalytic activity, and photophysical properties due to the prevention of π-π stacking in metal salicylaldimines.

10p vikwong 29-09-2024 5 1   Download

The purpose of the thesis research: Synthesis of new complexes of platinum and rare-earth elements containing quinoline's derivatives that are resistant to cancer cells, high antimicrobial activity or good fluorescence.

27p tunelove 10-06-2021 21 4   Download

Bài báo trình bày các kết quả tổng hợp và nghiên cứu cấu trúc của phức chất trans- [PtCl2(Meteug)(2-NH2C5H4N)] bằng phương pháp phổ IR, 1H NMR và đặc biệt là phương pháp nhiễu xạ tia X đơn tinh thể. Kết quả cho thấy 2-aminopyridine phối trí với Pt(II) qua nguyên tử N trong vòng pyridine, trong khi đó methyeugenoxyaxetat (Meteug) phối trí qua liên kết đôi của nhánh allyl. Mời tham khảo để biết thêm chi tiết.

6p estupendo5 31-08-2016 44 5   Download

trans-[PtCl2NH3(4-Hydroxymethylpyridine)] (trans-PtHMP) is an analogue of clinically ineffective transplatin, which is cytotoxic in the human leuke-mia cancer cell line. As DNA is a major pharmacological target of anti-tumor platinum compounds, modifications of DNA by trans-PtHMP and recognition of these modifications by active tumor suppressor protein p53 were studied in cell-free media using the methods of molecular biology and biophysics.

14p dell39 27-03-2013 49 4   Download

Deoxyribonuclease I (DNase I) footprinting methodology was used to analyze oligodeoxyribonucleotide duplexes containing unique and single, site-specific adducts of trinuclear bifunctional platinum compound, [{trans-PtCl(NH3 )2}2l-trans-Pt(NH3 )2{H2N(CH2 )6NH2}2 ] 4+ (BBR3464) and the results were compared with DNase I footprints of some adducts of con-ventional mononuclearcis-diamminedichloroplatinum(II) (cisplatin).

12p inspiron33 25-03-2013 45 3   Download

Cisplatin (cis-diamminedichloroplatinum) and related chemotherapeutic DNA-crosslinking agents are widely used to treat human cancers.Saccha-romyces cerevisiae with separate deletions of the genes encoding the trimeric protein serine⁄threonine phosphatase (Pph)3p–platinum sensitivity (Psy)4p–Psy2p complex, are more sensitive than the isogenic wild-type (WT) strain to cisplatin.

11p galaxyss3 07-03-2013 38 3   Download