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Platinum derivative
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Cisplatin-based concurrent chemoradiotherapy has been identified as the primary and standard treatment for locally advanced nasopharyngeal carcinoma (NPC). However, the side effects of cisplatin affect the compliance to therapy. Thus, the search for a platinum-based substitute for NPC has always been a research focus.
15p
visusanwojcicki
28-06-2022
7
2
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Metastatic pancreatic cancer (mPC) and its treatments signifcantly impact health-related quality of life (HRQoL). POLO, a randomized, double-blind, placebo-controlled phase 3 trial evaluated the efcacy of olaparib as maintenance therapy in germline BRCA mutated mPC patients who had not progressed during ≥16weeks of frst-line platinum-based chemotherapy. HRQoL was assessed using the EORTC QLQ-C30.
8p
visusanwojcicki
28-06-2022
12
2
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Gentamicin (GM) is a low-cost, low-resistance antibiotic commonly used to treat gram-negative bacterial diseases. Cisplatin (Csp) is a platinum-derived anti-neoplastic agent. This experiment aimed to identify the early signs of gentamicin and cisplatin-induced nephrotoxicity in rats.
9p
vidarwin
22-02-2022
12
1
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This paper presents the results of an investigation of the properties of a modified platinum electrode with meso-tetraphenylporphyrin iron(III) complex immobilized in Nafion film and its catalytic activity in the electrochemical oxidation of selected hydroquinone and catechol derivatives. The redox activity of iron complexes of porphyrins was characterized in aqueous solutions of perchloric acid by means of cyclic voltammetry and differential pulse voltammetry.
14p
langthannam
29-12-2021
4
0
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Enhanced electrocatalytic reduction of oxygen is achieved using Pt nanoparticle-modified copper phthalocyanine-multiwalled carbon nanotube (PtNPs/CuPc-CNT) composite film on a glassy carbon electrode (PtNPs/CuPcCNT/GCE). The PtNPs/CuPc-CNT/GCE surface is characterized by scanning electron microscopy, transmission electron microscopy, electrochemical impedance spectroscopy, X-ray photoelectron spectroscopy, and X-ray diffraction. The electrocatalytic activity of composite electrodes in the oxygen reduction reaction is investigated by cyclic voltammetry and rotating-disk electrode measurements.
16p
tudichquannguyet
29-11-2021
7
1
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Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in head and neck. Platinum-based chemotherapy is an important treatment for NPC. However, the molecular mechanism of resistance to platinum drug remains unknown.
13p
vimahuateng
26-11-2021
5
1
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The purpose of the thesis research: Synthesis of new complexes of platinum and rare-earth elements containing quinoline's derivatives that are resistant to cancer cells, high antimicrobial activity or good fluorescence.
27p
tunelove
10-06-2021
15
4
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Platinum(II) complex of benzimidazole-derived N-heterocyclic carbene with formula [PtCl2(DMSO)(bimy)] was successfully synthesized via one pot reaction between 1,3-diisopropyl benzimidazolium (bimyHBr), Ag2O and [PtCl2(DMSO)] (DMSO = dimethyl sulfoxide). The complex was characterized by means of multinuclear (1H and 13C{1H}) magnetic resonance and single crystal X-ray diffraction (XRD). The UV-Vis absorption spectra of the compound show an absorption shoulder above 300 nm.
7p
kequaidan11
07-04-2021
24
2
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The interactions of K[PtCl3( i PrEug)] with either 2-aminopyridine (NH2Py) or 2-(aminomethyl)pyridine (NH2CH2Py) have been studied for the first time. The structures of obtained complexes, namely trans-[PtCl2( i PrEug)(NH2Py)] (2) and a mixture of [PtCl2(NH2CH2Py)] (3A) and trans-[PtCl2(NH2CH2Py)2] (3B), were determined by means of platinum analysis, EDX, IR, 1H NMR spectroscopy.
8p
tamynhan9
02-12-2020
4
1
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Current treatment of ovarian cancer patients with chemotherapy leaves behind a residual tumor which results in recurrent ovarian cancer within a short time frame. We have previously demonstrated that a single short-term treatment of ovarian cancer cells with chemotherapy in vitro resulted in a cancer stem cell (CSC)-like enriched residual population which generated significantly greater tumor burden compared to the tumor burden generated by control untreated cells.
22p
virose2711
24-09-2020
17
0
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Combination of fluoropyrimidines and a platinum derivative are currently standards for systemic chemotherapy in advanced adenocarcinoma of the stomach and gastroesophageal junction (GEJ). Nevertheless, individual likelihood for response to these therapeutic regimes remains uncertain.
9p
virose2711
22-09-2020
10
2
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Anti-cancer effect and gene modulation of ET-743 in human biliary tract carcinoma preclinical models
Standard chemotherapy in unresectable biliary tract carcinoma (BTC) patients is based on gemcitabine combined with platinum derivatives. However, primary or acquired resistance is inevitable and no second-line chemotherapy is demonstrated to be effective.
10p
vilisa271
22-09-2020
12
0
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No previous study has addressed the efficacy of NF-κB blockade when bladder tumors develop acquired resistance toward CDDP-treatments. We investigated the changes in NF-κB activation and therapeutic impact of NF-κB blockade by the novel NF-κB inhibitor dehydroxymethyl derivative of epoxyquinomicin (DHMEQ) in CDDP-resistant bladder cancer cells.
11p
vialabama2711
21-09-2020
12
1
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Oxaliplatin is a platinum derivative that has shown efficacy in advanced hepatocellular carcinoma. S-1 is an oral fluoropyrimidine that has substituted for 5-fluorouracil in many cancers.
7p
vibaku2711
22-07-2020
11
2
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Olaratumab is a platelet-derived growth factor receptor-α (PDGFRα)-targeting monoclonal antibody blocking PDGFRα signaling. PDGFRα expression is associated with a more aggressive phenotype and poor ovarian cancer outcomes.
11p
viputrajaya2711
22-06-2020
6
0
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To date, the cornerstone of treatment in patients with advanced or metastatic cholangiocarcinoma (CCA) is systemic chemotherapy based on a combination of gemcitabine and a platinum derivative.
10p
viputrajaya2711
22-06-2020
8
0
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Platinum derivatives are used widely for the treatment of many cancers. However, the toxicity that is observed makes imperative the need for new drugs, or new combinations. Anvirzel™ is an extract which has been demonstrated with experimental data that displays anticancer activity.
6p
vienzym2711
03-04-2020
13
1
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