polar molecules

A central metal atom bonded to a group of molecules or ions is a metal complex. • If it’s charged, it’s a complex ion. Chemistry • Compounds containing complexes are coordination of Coordination Compounds compounds.The molecules or ions coordinating to the metal are the ligands.

77p tringuyen215dh11h1 05-10-2013 61 5   Download

Inducible nitric oxide synthase (iNOS) functions as a homodimer. In cell extracts, iNOS molecules partition both in cytosolic and particulate frac-tions, indicating that iNOS exists as soluble and membrane associated forms. In this study, iNOS features were investigated in human intestinal epithelial cells stimulated with cytokines and in duodenum from mice exposed to flagellin. Our experiments indicate that iNOS is mainly associ-ated with the particulate fraction of cell extracts.

10p awards 05-04-2013 34 4   Download

The protein arginine methyltransferase (PRMT) family of enzymes cata-lyzes the transfer of methyl groups from S-adenosylmethionine to the gua-nidino nitrogen atom of peptidylarginine to form monomethylarginine or dimethylarginine. We created several less polar analogs of the specific PRMT inhibitor arginine methylation inhibitor-1, and one such compound was found to have improved PRMT inhibitory activity over the parent molecule.

13p mobifone23 21-01-2013 37 6   Download