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Possible immune mechanisms
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The optimal duration of anti-PD-1 for cancer therapy has not been tested, especially when using combination therapy. Epidermal growth factor receptor (EGFR) pathway blocker was the top compound that enhanced T-cell killing of tumor cells in a high-throughput immune-oncology screen, possibly by stimulate the antigen presentation machinery and other mechanisms.
9p
vileonardodavinci
23-12-2023
2
2
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Lupus miliaris disseminatus faciei (LMDF), an uncommon inflammatory granulomatous dermatosis with possible immune mechanisms, affects young adults. We report a typical case of LMDF on a 28-yearold male patient diagnosed by clinical and histopathology
4p
viberbers
09-08-2023
5
2
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The combined application of immune cells and specific biomarkers related to the tumor immune microenvironment has a better predictive value for the prognosis of HCC. The purpose of this study is to construct a new prognostic model based on immune-related genes that regulate cross-talk between immune and tumor cells to assess the prognosis and explore possible mechanisms.
18p
vikolindagrabar
27-07-2022
6
2
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microRNAs (miRNAs) are single-stranded and noncoding RNA molecules that control posttranscriptional gene regulation. miRNAs can be tumor suppressors or oncogenes through various mechanism including cancer cell biology, cell-to-cell communication, and anti-cancer immunity.
12p
vidietmarhopp
28-12-2021
6
0
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This work intended to investigate the predictive ability of KLRG1 on the efficacy of immune-checkpoint inhibitor in the treatment of lung adenocarcinoma (LUAD), as well as contribute to the possible molecular mechanisms of KLRG1 on LUAD development.
16p
vimahuateng
26-11-2021
12
1
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During initial characterization, we observed significant reproductive cycle-based variation in infection outcome. When uterine infection occurred in the diestrus phase, there was significantly greater pathology than during estrus phase. The aim of this study was to evaluate transcriptional profiles of infected uterine tissue from mice in either estrus or diestrus phase in order to elucidate possible mechanisms for these differences.
19p
vitzuyu2711
29-09-2021
11
1
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While technological advances have made it possible to profile the immune system at high resolution, translating high-throughput data into knowledge of immune mechanisms has been challenged by the complexity of the interactions underlying immune processes.
18p
vicolorado2711
22-10-2020
8
2
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Cancer research has devoted most of its energy over the past decades on unraveling the control mechanisms within tumor cells that govern its behavior. From this we know that the onset of cancer is the result of cumulative genetic mutations and epigenetic alterations in tumor cells leading to an unregulated cell cycle, unlimited replicative potential and the possibility for tissue invasion and metastasis.
12p
vijisoo2711
30-09-2020
5
1
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As one of the genetic mechanisms for adaptive immunity, V(D)J recombination generates an enormous repertoire of T-cell receptors (TCRs). With the development of high-throughput sequencing techniques, systematic exploration of V(D)J recombination becomes possible.
10p
viuchiha2711
21-04-2020
8
0
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In this paper, we review the different mechanisms of the human immune system in inhibiting cancer grow and the possible loopholes allowing the cancer cell to evade the immune system response.
7p
vixyliton2711
17-04-2019
13
0
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Poultry manure production occurs as a result of the normal everyday processes of the poultry industry. It is a valuable by-product of this industry and has valuable potential uses beyond the traditional one of fertilizer . It is always interesting to note that if one were looking 5 strictly at the fate of the nutrient inputs, the major product of any animal feeding system is manure, not animal protein . Often manures are considered waste materials and a place to 26 dispose of them has to be found. However, if the manure is considered a by-product of the industry, a possible use...
14p
loginnhanh
22-04-2013
65
1
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Multisite protein phosphorylation is a common regulatory mechanism in cell signaling, and dramatically increases the possibilities for protein– protein interactions, conformational regulation, and phosphorylation path-ways. However, there is at present no comprehensive picture of how these factors shape the response of a protein’s phosphorylation state to changes in kinase and phosphatase activities.
16p
galaxyss3
21-03-2013
40
3
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Paying Down Budgetary Liabilities? As discussed above, our forecast assumes that special fund loans to the General Fund are paid back consistent with recent repayment schedules provided by the administration and that $1.2 billion of such loans remain outstanding by the end of 2017-18. The state could choose to pay down these loans faster.
265p
doiroimavanchuadc
19-02-2013
49
5
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We planned the first edition of this book on a ‘need to know’ basis, its primary object being to provide students and medical and dental practitioners with the knowledge essential for an informed approach to the prevention and treatment of viral infections. We aimed also at supplying just enough basic virology to underpin the more practical aspects—clinical manifestations, epidemiology, pathogenesis, immune responses, and so forth. And not least, we tried our best to make the text as readable as is possible, given the highly technical nature of some of the material.
142p
mnemosyne75
02-02-2013
75
9
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Glucokinase (GK) is the central player in glucose-stimulated insulin release from pancreatic b-cells, and catalytic activation by a-D-glucose binding has a key regulatory function. Whereas the mechanism of this activation is well understood, on the basis of crystal structures of human GK, there are no similar structural data on ATP binding to the ligand-free enzyme and how it affects its conformation.
15p
cosis54
05-01-2013
43
3
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Glassware must be scrupulously cleaned. Clean all glassware as soon as 3 possible after use by rinsing with the last solvent used in it. Solvent rinsing should be followed be detergent washing with hot water, and rinses with tap water and distilled water. The glassware should then be drained dry, and heated in a muffle furnace at 400°C for 15-30 minutes. Some thermally stable materials, such as PCBs, may not be eliminated by this treatment. Solvent rinses with acetone and pesticide quality hexane may be substituted for the muffle furnace heating.
8p
cao_can
02-01-2013
59
2
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The elderly disabled often have numerous chronic conditions and functional disabilities that require clinicians and service providers to take an ongoing cooperative management approach with the patient and family. The goal of this approach is to live the best possible life with chronic problems and avoid preventable deterioration of health and functional ability.
172p
ut_hai_can
26-12-2012
58
5
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The imagination is questionable (Daily, 1997; Dasgupta, 2000b). In any event, we should be sceptical of a theory which places such enormous burden on an experience not much more than two hundred years old (Fogel, 1994; Johnson, 2000). Extrapolation into the past is a sobering exercise: over the long haul of history (some five thousand years), economic growth even in the currently-rich countries was for most of the time not much above zero.
42p
thankinhphanliet
21-12-2012
44
7
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The clinical and basic science of allergic disease is moving and evolving so rapidly that it is nearly impossible to keep up full of information regarding the news mechanisms, signalling cell markers, cellular plasticity and expression, biological mediators targets or molecular and genetic discovers aspects related to the allergy. Moreover the systemic impact of this pathology determines the complexity of the more recent evidence demonstrates that the rapid regulation of central immune organs in clinical response of the mucosa to the allergen or offending agent.
284p
wqwqwqwqwq
21-07-2012
114
14
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Toll-like receptor 4 (TLR4) plays an important role in innate immunity. The role of TLR4 in stretched cardiomyocytes is not known. We sought to investigate whether mechanical stretch could regulate TLR4 expression, as well as the possible molecular mechanisms and signal pathways mediating the expression of TLR4 by cyclic mechanical stretch in cardiomyocytes. Methods: Neonatal Wistar rat cardiomyocytes grown on a flexible membrane base were stretched by vacuum to 20% of maximum elongation at 60 cycles/min.
13p
toshiba23
18-11-2011
70
3
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