Potency selectivity expression

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Synthesis and biological evaluation of new pyrazolebenzene-sulphonamides as potential anticancer agents and hCA I and II inhibitors

Cancer is a disease characterized by the continuous growth of cells without adherence to the rules that healthy normal cells obey. Carbonic anhydrase I and II (CA I and CA II) inhibitors are used for the treatment of some diseases. The available drugs in the market have limitations or side effects, which bring about the need to develop new drug candidate compound(s) to overcome the problems at issue.

35p tudichquannguyet 29-11-2021 5 1 Download

Báo cáo Y học: Selection of effective antisense oligodeoxynucleotides with a green ﬂuorescent protein-based assay Discovery of selective and potent inhibitors of glutathione S-transferase Mu expression

Antisense oligodeoxynucleotides (AS-ODNs) are frequently used for the down-regulation of protein expression.Because the majority of potential antisense sequences lacks effect-iveness, fast screening methods for the selection of effective AS-ODNs are needed.We describe a new cellular screening assay for the evaluationof the potency and specificityof new antisense sequences.

10p research12 29-04-2013 31 2 Download