Potential cytotoxic agents

Over the past decades, researchers and scientists have paid more and more attention to the discovery of novel antibiotics and anticancer agents in fighting infection and cancer diseases. It is believed that endophytic actinomycetes from medicinal plants provide abundant resources for new compounds with significant bioactive properties. In the present study, we assessed antibacterial and cytotoxic activities of endophytic actinomycetes associated with Litsea cubeba (Lour.) Pers.

11p vidudley 20-02-2023 7 2   Download

Nano-sized materials have shown to have very high potential in anticancer therapy by an adequate tuning of their functionalization and physico-chemical properties. This study is focused on the synthesis and characterization of mesoporous silica nanoparticles (MSN) functionalized with a titanium(IV) or an organotin(IV) compound (therapeutic agents), fluorescein isothiocyanate (image agent) and transferrin (targeting molecule).

15p vironald 15-12-2022 8 2   Download

Photodynamic therapy (PDT) applications enable light-controlled activation of drug candidates instead of their constitutive activities to prevent undesired side effects associated with their constant activities. A specific wavelength of light is utilized to enable electron mobility in the chemical structure, which results in differential activities that may alter cell viability and cellular functions. Canonical photodynamic therapy applications mostly focus on cytotoxicity-based antimicrobial and anticancer properties of the PDT agents.

9p langthannam 29-12-2021 9 0   Download

Cancer is one of the main global health problems. In order to develop novel antitumor agents, we synthesized 3,4-dihydropyrimidine-2(1H)-one (DHPM) and 2,6-diaryl-substituted pyridine derivatives as potential antitumor structures and evaluated their cytotoxic effects against several cancer cell lines. An easy and convenient method is reported for the synthesis of these derivatives, employing cobalt ferrite (CoFe 2 O4 @SiO2 -SO3 H) magnetic nanoparticles under microwave irradiation and solvent-free conditions.

20p tudichquannguyet 29-11-2021 7 1   Download

3-acetyl coumarin derivatives (1a-d) are formed as a result of condensation of salicylaldehyde derivatives and ethyl acetoacetate and were converted into coumarin-selenophene hybrid compounds (2a-d) in the basic medium by modified Gewald reaction in the presence of malononitrile and selenium. Products are characterized by nuclear magnetic resonance (NMR). The prepared compounds are screened for their anticancer activity against DU-145 cell line. In addition, selected target compounds are evaluated for apoptosis and oxidative stress on DU-145 (prostate carcinoma) cell lines.

16p tudichquannguyet 29-11-2021 10 1   Download

In this study, we evaluated the cytotoxic activity of a novel naphthoquinone-derived compound (1,4-naphthoquinone (1,4-NQ)) against two different breast cancer cells: a hormone-responsive cell line (MCF-7) and a triple-negative cell line (MDA-MB-231). As a result, 1,4-NQ decreased cell viability in both tested cell lines in a dose-dependent manner. Increased apoptotic markers (presence of pyknotic nuclei, annexin-V positivity, caspase 3/7 activity, and decreased mitochondrial membrane potential) and DNA damage were especially observed in MDA-MB-231 cells after treatment with the compound.

8p thiencuuchu 27-11-2021 20 0   Download

Chk1 inhibitors are currently in clinical trials in combination with a range of cytotoxic agents and have the potential to potentiate the clinical activity of a large number of standard of care chemotherapeutic agents.

13p virose2711 22-09-2020 12 2   Download

Triple negative breast cancer (TNBC) is a distinct subtype of breast cancer burdened with a dismal prognosis due to the lack of effective therapeutic agents. Receptors for LHRH (luteinizing hormone-releasing hormone) can be successfully targeted with AEZS-108 [AN-152], an analog of LHRH conjugated to doxorubicin.

12p vilisa271 22-09-2020 9 0   Download

Chk1 inhibitors are currently in clinical trials as putative potentiators of cytotoxic chemotherapy drugs. Chk1 inhibitors may exhibit single agent anti-tumor activity in cancers with underlying DNA repair, DNA damage response or DNA replication defects.

14p vilisa271 22-09-2020 9 0   Download

Solid tumors, such as hepato-pancreato-biliary cancer, develop tumor hypoxia with tumor growth. Despite advances in surgery, a majority of these patients are in an unresectable condition. At this stage standard cytotoxic chemotherapy regimens are applied with limited success.

6p vimale2711 25-08-2020 4 1   Download

Photodynamic therapy (PDT) has proven to be a promising alternative to current cancer treatments, especially if combined with conventional approaches. The technique is based on the administration of a non-toxic photosensitizing agent to the patient with subsequent localized exposure to a light source of a specific wavelength, resulting in a cytotoxic response to oxidative damage.

12p vimale2711 21-08-2020 13 1   Download

Green nanomaterials have gained much attention due to their potential use as therapeutic agents. The present study investigated the production of silver nanoparticles (AgNPs) from a silver-resistant Bacillus safensis TEN12 strain, which was isolated from metal contaminated soil and taxonomically identified through 16S rRNA gene sequencing. The formation of AgNPs in bacterial culture was confirmed by using UV–vis spectroscopy with an absorption peak at 426.18 nm.

9p covid19 14-06-2020 14 0   Download

4-Thiazolidinone ring is reported to have almost all types of biological activities. Also, it present in many marketed drugs. An unexpected synthesis of (Z)-ethyl 2-((Z)-5-((dimethylamino)methylene)-4-oxo-3-phenylthiazolidin2-ylidene)acetate via deacetylation mechanism.

11p vijiraiya2711 27-05-2020 13 1   Download

In search of new antimicrobial and cytotoxic agents, a series of new naphthol diazenyl scaffold based Schiff bases (NS1–NS23) was efciently synthesized by condensation of 2-hydroxy naphthaldehyde azo dyes with various substituted aromatic/heteroaromatic/aliphatic amines.

19p vijiraiya2711 27-05-2020 15 1   Download

With the improvement and advance in cancer diagnosis and treatment, the cancer is still a major cause of morbid‑ ity and mortality throughout the world. Obviously, new breakthroughs in therapies remain be urgent needed.

10p vijiraiya2711 27-05-2020 10 0   Download

A series of diamides derivatives containing nicotinamide unit were designed, synthesized and evaluated for their potential cytotoxic activities against human cancer cell lines.

9p vijiraiya2711 27-05-2020 11 1   Download

The synthesis of new thiazole derivatives is very important because of their diverse biological activities. Also , many drugs containing thiazole ring in their skeletons are available in the market such as Abafungin, Acotia‑ mide, Alagebrium, Amiphenazole, Brecanavir, Carumonam, Cefepime, and Cefmatilen.

9p vijiraiya2711 27-05-2020 12 1   Download

Emergence of different life style diseases increases the scope for developing natural remedies. Strychnos potatorum is a traditional medicinal plant used in the treatment of Asthma, diabetes, urinary infection etc. In the present analysis it was found that it is potential antioxidant agent. HPLC analysis showed that it contains flavanoids like Kaempherol and quercetin.

10p chauchaungayxua4 18-03-2020 10 1   Download

This study determined the optimal nutrient and environmental conditions to produce antimicrobial and cytotoxic agents by Streptomyces cavourensis YBQ59 during the fermentation process. The bioactivities of eluted fractions based gradient solvents via chromatography column were also evaluated. S.

9p chauchaungayxua2 07-01-2020 49 0   Download

Resistance of solid tumors to treatment is significantly attributed to pharmacokinetic reasons at both cellular and multi-cellular levels. Anticancer agent must be bio-available at the site of action in a cytotoxic concentration to exert its proposed activity. P-glycoprotein (P-gp) is a member of the ATP-dependent membrane transport proteins; it is known to pump substrates out of cells in ATP-dependent mechanism. The over-expression of P-gp in tumor cells reduces the intracellular drug concentrations, which decreases the cytotoxicity of a broad spectrum of antitumor drugs.

18p trinhthamhodang1 16-11-2019 13 1   Download