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Precise deletion
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Many applications of CRISPR/Cas9-mediated genome editing require Cas9-induced non-homologous end joining (NHEJ), which was thought to be error prone. However, with directly ligatable ends, Cas9-induced DNA double strand breaks may be repaired preferentially by accurate NHEJ.
20p
vigalileogalilei
27-02-2022
10
1
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The CRISPR/Cas9 system has become an efficient gene editing method for generating cells carrying precise gene mutations, including the rearrangement and deletion of chromosomal segments. However, whether an entire chromosome could be eliminated by this technology is still unknown.
18p
vialfrednobel
29-01-2022
14
0
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The CRISPR-Cas9 system is frequently used to create small deletions in the genomes of mammalian cells, but the isolation of precisely targeted mutants is still challenging. A new, two-step ‘pop in & out’ targeting approach facilitates this task.
3p
viaristotle
29-01-2022
8
0
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The recent advances in agricultural biotechnology and genetic engineering have brought numerous benefits to the food and agricultural sector by improving the essential characteristics of plant agronomic traits. Targeted genome editing using sequence specific nucleases (SSNs) provides a general method for inducing targeted deletions, insertions and precise sequence changes in a broad range of organisms and cell types.
15p
chauchaungayxua11
23-03-2021
12
2
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Tuyển tập những bài báo cáo nghiên cứu khoa học hay nhất được đăng trên tạp chí JOURNAL OF FOREST SCIENCE đề tài: Improving RBS estimates – effects of the auxiliary variable, stratification of the crown, and deletion of segments on the precision of estimates...
14p
toshiba3
09-09-2011
49
2
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Unequal Crossing-Over Normally, DNA recombination in germ cells occurs with remarkable fidelity to maintain the precise junction sites for the exchanged DNA sequences (Fig. 62-3). However, mispairing of homologous sequences leads to unequal crossover, with gene duplication on one of the chromosomes and gene deletion on the other chromosome. A significant fraction of growth hormone (GH) gene deletions, for example, involve unequal crossing-over (Chap. 333).
5p
konheokonmummim
03-12-2010
61
3
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