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Precision phenotyping
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Phenotypic changes during cancer progression are associated with alterations in gene expression, which can be exploited to build molecular signatures for tumor stage identification and prognosis. However, it is not yet known whether the relative abundance of transcript isoforms may be informative for clinical stage and survival.
14p
vioraclene
31-03-2024
5
2
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Sleep-disordered breathing is a common disorder associated with significant morbidity. The genetic architecture of sleep-disordered breathing remains poorly understood. Through the NHLBI Trans-Omics for Precision Medicine (TOPMed) program, we performed the first whole-genome sequence analysis of sleep-disordered breathing.
17p
vibransone
28-03-2024
4
2
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Genomics enables individualized diagnosis and treatment, but large challenges remain to functionally interpret rare variants. To date, only one causative variant has been described for KCNK9 imprinting syndrome (KIS). The genotypic and phenotypic spectrum of KIS has yet to be described and the precise mechanism of disease fully understood.
19p
viellison
28-03-2024
7
2
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Despite recent advances in research, there are still critical lacunae in our basic understanding of the cause, pathogenesis, and natural history of many cancers, especially heterogeneity in patient response to drugs and mediators in the transition from malignant to invasive phenotypes.
24p
vioracle
29-09-2023
4
2
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Despite increased risk for negative outcomes, cognitive impairment (CI) is greatly under-detected during hospitalization. While automated EHR-based phenotypes have potential to improve recognition of CI, they are hindered by widespread under-diagnosis of underlying etiologies such as dementia—limiting the utility of more precise structured data elements.
7p
visteverogers
24-06-2023
3
2
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Plant height is a prime example of a dynamic trait that changes constantly throughout adult development. In this study we utilised a large triticale mapping population, comprising 647 doubled haploid lines derived from 4 families, to phenotype for plant height by a precision phenotyping platform at multiple time points.
8p
vinarcissa
21-03-2023
9
1
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Spatial mapping of genomic data to tissue context in a high-throughput and high-resolution manner has been challenging due to technical limitations. Here, we describe PHLI-seq, a novel approach that enables high-throughput isolation and genome-wide sequence analysis of single cells or small numbers of cells to construct genomic maps within cancer tissue in relation to the images or phenotypes of the cells.
17p
vigalileogalilei
27-02-2022
9
1
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Massive genome sequencing data have inspired new challenges in personalized treatments and facilitated oncological drug discovery. We present a comprehensive database, My Personal Mutanome (MPM), for accelerating the development of precision cancer medicine protocols.
18p
viarchimedes
26-01-2022
8
1
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Studies that aim at explaining phenotypes or disease susceptibility by genetic or epigenetic variants often rely on clustering methods to stratify individuals or samples. While statistical associations may point at increased risk for certain parts of the population, the ultimate goal is to make precise predictions for each individual.
8p
viseulgi2711
31-08-2021
8
1
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The precise classifcation of idiopathic interstitial pneumonia (IIP) is essential for selecting treatment as well as estimating clinical outcomes; however, this is sometimes difficult in clinical practice. Therefore, cluster analysis was used to identify the clinical phenotypes of IIPs, and its usefulness for predicting clinical outcomes was evaluated.
9p
vimichigan2711
26-03-2021
10
2
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Precision medicine requires the tight integration of clinical and molecular data. To this end, it is mandatory to define proper technological solutions able to manage the overwhelming amount of high throughput genomic data needed to test associations between genomic signatures and human phenotypes.
11p
vioklahoma2711
19-11-2020
11
1
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Nuclear segmentation is an important step for profiling aberrant regions of histology sections. If nuclear segmentation can be resolved, then new biomarkers of nuclear phenotypes and their organization can be predicted for the application of precision medicine.
11p
viconnecticut2711
28-10-2020
15
1
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Bacterial blight (BB) is a major disease of rice for which host resistance is the only effective solution. Pyramiding entails stacking multiple genes leading to the simultaneous expression of more than one gene in a variety to develop durable resistance Expression. Gene pyramiding is gaining considerable importance as it would improve the efficiency of plant breeding leading to the development of genetic stocks and precise development of broad spectrum resistance capabilities.
5p
kethamoi4
16-04-2020
11
1
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Precise spatial positioning and isolation of mammalian cells is a critical component of many single cell experimental methods and biological engineering applications. Although a variety of cell patterning methods have been demonstrated, many of these methods subject cells to high stress environments, discriminate against certain phenotypes, or are a challenge to implement.
9p
vihamax2711
21-04-2020
10
1
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The material for the study consisted of twenty genotypes of Bhindi, which were grown in a Randomized Block Design (RBD) with three replication under six environments (three different dates of sowing in Spring-summer and Kharif). The observations were recorded on five randomly selected plants for characters viz., plant height (cm). no. of branches per plant, days to first flowering, days to first harvest, number of fruits per plant, fruit length (cm), fruit diameter (cm), fruit weight (g), fruit yield per plant(kg) and fruit yield per plot(kg).
11p
nguaconbaynhay3
07-02-2020
16
0
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Molecular genetic markers correspond to highly potent source for the study of plant genomes and the association of inherited phenotypic traits with underneath genetic variation. Single Nucleotide Polymorphism (SNPs) are most abundant form of molecular genetic marker which represents a single nucleotide difference between two individuals at a defined location. Compare to others SNPs are direct sequence variation which offers the precise nature of the allelic variants among different genotypes. Further, it signify recurrent type of genetic polymorphism with high density genome coverage.
11p
nguaconbaynhay1
04-12-2019
26
0
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Reversal of carbapenem-resistance in Shewanella algae by CRISPR/Cas9 genome editing Antibiotic resistance in pathogens is a growing threat to human health. Of particular concern is resistance to carbapenem, which is an antimicrobial agent listed as critically important by the World Health Organization. With the global spread of carbapenem-resistant organisms, there is an urgent need for new treatment options. Shewanella algae is an emerging pathogen found in marine environments throughout the world that has increasing resistance to carbapenem.
9p
caygaocaolon1
13-11-2019
17
0
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Because there is no clear definition of the asthma phenotype, researchers studying the development of this complex disease turn to characteristics that can be measured objectively, such as atopy (manifested as the presence of positive skin-prick tests or the clinical response to common environmental allergens), airway hyperresponsiveness (the tendency of airways to narrow excessively in response to triggers that have little or no effect in normal individuals), and other measures of allergic sensitization.
170p
dacotaikhoan
26-04-2013
59
9
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How different levels of genetic variance affect the rate of evolutionary change within populations has also been intensively studied. Such changes were originally studied using phenotypic markers: variation among individual plants in traits, such as leaf shape or flower color (Ward et al., 2008). Subsequently the detection of genetic variation has become more sensitive, firstly through the utilization of variation in enzymes (allozymes) and then through PCR-based marker systems allowing direct examination of DNA sequence variation.
288p
conquynho32
18-09-2012
58
9
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