Prediction of response

This study focuses on developing the predicted models of materials removal rate and tool wear rate by utilizing the response surface method (RSM) for the machining of SKD61 steel by EDM process with adding tungsten compound powder.

14p vithomson 02-07-2024 0 0   Download

Immunotherapy based on the application of immune checkpoint inhibitors (ICIs) is one of the standard treatments for advanced non-small cell lung cancer (NSCLC). Non-alcoholic fatty liver Disease (NAFLD) has demonstrated predictive value for response to immunotherapy in non-lung cancer types.

10p vishanshan 27-06-2024 2 1   Download

Accurate assessment of axillary status after neoadjuvant therapy for breast cancer patients with axil‑ lary lymph node metastasis is important for the selection of appropriate subsequent axillary treatment decisions. Our objectives were to accurately predict whether the breast cancer patients with axillary lymph node metastases could achieve axillary pathological complete response (pCR).

13p vishanshan 27-06-2024 2 1   Download

To predict pathological complete response (pCR) in patients receiving neoadjuvant immunochemotherapy (nICT) for esophageal squamous cell carcinoma (ESCC), we explored the factors that influence pCR after nICT and established a combined nomogram model.

12p vishanshan 27-06-2024 2 1   Download

High expression of the glycosyltransferase UGT2B17 represents an independent adverse prognostic marker in chronic lymphocytic leukemia (CLL). It also constitutes a predictive marker for therapeutic response and a drug resistance mechanism.

12p vishanshan 27-06-2024 1 1   Download

Clear cell carcinoma of the kidney is a common urological malignancy characterized by poor patient prognosis and treatment outcomes. Modulation of vasculogenic mimicry in tumor cells alters the tumor microenvironment and the influx of tumor-infiltrating lymphocytes, and the combination of its inducers and immune checkpoint inhibitors plays a synergistic role in enhancing antitumor effects.

16p vishanshan 27-06-2024 1 1   Download

Although substantial efforts have been made to build molecular biomarkers to predict radiation sensitivity, the ability to accurately stratify the patients is still limited. In this study, we aim to leverage large-scale radiogenomics datasets to build genomic predictors of radiation response using the integral of the radiation dose–response curve.

10p vishanshan 27-06-2024 1 1   Download

Postoperative central diabetes insipidus (CDI) is commonly observed in craniopharyngioma (CP) patients, and the inflammatory response plays an important role in CPs. We aimed to evaluate the predictive value of preoperative peripheral inflammatory markers and their combinations regarding CDI occurrence in CPs.

9p vishanshan 27-06-2024 2 1   Download

Basement membrane (BM) is an important component of the extracellular matrix, which plays an important role in the growth and metastasis of tumor cells. However, few biomarkers based on BM have been developed for prognostic assessment and prediction of immunotherapy in bladder cancer (BLCA).

13p vikoch 27-06-2024 2 1   Download

To improve the prognosis of patients with metastatic colorectal cancer (mCRC), investigating predictive biomarkers of their prognosis and chemotherapeutic responsiveness is necessary. This study aimed to analyze the clinical significance of serum proteinase-3 (PRTN3) as a predictor for prognosis and chemosensitivity, especially to bevacizumab therapy, in mCRC.

15p vikoch 27-06-2024 1 1   Download

Predicting tumor responses to neoadjuvant chemotherapy (NAC) is critical for evaluating prognosis and designing treatment strategies for patients with breast cancer; however, there are no reliable biomarkers that can effectively assess tumor responses. Therefore, we aimed to evaluate the clinical feasibility of using extracellular vesicles (EVs) to predict tumor response after NAC.

12p vikoch 27-06-2024 1 1   Download

In this study, we employ MaxEnt, a widely used species distribution modeling method, to predict climatically suitable habitat for P. nemaeus at present, and then project the optimal model using a range of future climate change scenarios to understand the possible shifts in response to climate change over the entire range of the Red-shanked Douc.

10p viambani 18-06-2024 1 1   Download

Ebook "Construction and real estate dynamics" deals with some interesting economic questions related to construction and real estate, namely how construction firms cope with the volatility of construction; whether speculative bubbles or market fundamentals drive those fluctuations; new techniques to predict construction demand; why the office market led the recent real estate cycle; and whether regulation is responsible for speculative behaviour.

151p dongmelo 26-05-2024 6 3   Download

Ebook "Protein acetylation: Methods and protocols" expert researchers in the field detail many of the methods which are now commonly used to study protein acetylation. These include methods and techniques for identification of protein acetylation, column- and gel electrophoresis-based approaches, computationally prediction, and the biological response to protein acetylation.

279p dongmelo 27-05-2024 2 2   Download

Part 2 book "Mineral nutrition of livestock" includes content: Iodine, iron, manganese, selenium, zinc, occasionally beneficial elements, potentially toxic elements, predicting mineral responses, minerals and humans.

300p muasambanhan10 03-04-2024 4 1   Download

Comprehensive mutational profiling data now available on all major cancers have led to proposals of novel molecular tumor classifications that modify or replace the established organ- and tissue-based tumor typing. The rationale behind such molecular reclassifications is that genetic alterations underlying cancer pathology predict response to therapy and may therefore offer a more precise view on cancer than histology.

17p vibransone 28-03-2024 4 2   Download

Circulating tumor (ct) DNA is a powerful tool that can be used to track cancer beyond a single snapshot in space and time. It has potential applications in detecting minimal residual disease and predicting relapse, in selecting patients for tailored treatments, and in revealing mechanisms of response or resistance. Here, we discuss the incorporation of ctDNA into clinical trials.

4p vibransone 28-03-2024 4 2   Download

Measures of the adaptive immune response have prognostic and predictive associations in melanoma and other cancer types. Specifically, intratumoral T cell density and function have considerable prognostic and predictive value in skin cutaneous melanoma (SKCM).

11p vibransone 28-03-2024 2 2   Download

Personalized care of cancer patients undergoing treatment with immune checkpoint inhibitors will require approaches that can predict their susceptibility to immune-related adverse events. Understanding the role of germline genetic factors in determining individual responses to immunotherapy will deepen our understanding of immune toxicity and, importantly, it may lead to tools for identifying patients who are at risk.

3p vibransone 28-03-2024 4 1   Download

Immune checkpoint blockade (ICB) with antibodies inhibiting cytotoxic T lymphocyte-associated protein-4 (CTLA-4) and programmed cell death protein-1 (PD-1) (or its ligand (PD-L1)) can stimulate immune responses against cancer and have revolutionized the treatment of tumors.

13p vibransone 28-03-2024 8 2   Download