Predisposition to disease

New technologies have led to revisiting of the individual-collective relation in public health …and to questions of their impact on health inequalities The upholding of ‘choice’ coincides with new forms of stratification No consistency in argument Examples: nutrigenetics, obesity and functional foods

35p nhocbuonthich 18-06-2012 80 11   Download

Steven K Lundy, Sujata Sarkar, Laura A Tesmer and David A Fox Department of Internal Medicine, Division of Rheumatology and Rheumatic Diseases Core Center, University of Michigan Medical School, 4043 Biomedical Sciences Research Bldg., 109 Zina Pitcher Pl., Ann Arbor, MI 48109-2200, USA Corresponding author: David A Fox, dfox@umich.edu Published: 13 February 2007 This article is online at http://arthritis-research.com/content/9/1/202 © 2007 BioMed Central Ltd Arthritis Research & Therapy 2007, 9:202 (doi:10.

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Pathogenesis The multicentric nature of the disease and high rate of recurrence has led to the hypothesis of a field defect in the urothelium that results in a predisposition to cancer. Molecular genetic analyses suggest that the superficial and invasive lesions develop along distinct molecular pathways in which primary tumorigenic aberrations precede secondary changes associated with progression to a more advanced stage.

5p konheokonmummim 03-12-2010 73 5   Download

Many disorders exhibit the feature of locus heterogeneity, which refers to the fact that mutations in different genes can cause phenotypically similar disorders. For example, osteogenesis imperfecta (Chap. 357), long QT syndrome (Chap. 226), muscular dystrophy (Chap. 382), homocystinuria (Chap. 358), retinitis pigmentosa (Chap. 29), and hereditary predisposition to colon cancer (Chap. 87) or breast cancer (Chap. 86) can each be caused by mutations in distinct genes.

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Medical Ethics and New Technologies The rapid pace of technological advances has profound implications for medical applications far beyond their traditional roles to prevent, treat, and cure disease. Cloning, genetic engineering, gene therapy, human-computer interfaces, nanotechnology, and designer drugs have the potential to modify inherited predispositions to disease, select desired characteristics in embryos, augment "normal" human performance, replace failing tissues, and substantially prolong life span.

5p tubreakdance 26-11-2010 85 6   Download