Prime editor

Prime editors, novel genome-editing tools consisting of a CRISPR-Cas9 nickase and an engineered reverse transcriptase, can induce targeted mutagenesis. Nevertheless, much effort is required to optimize and improve the efficiency of prime-editing.

11p viarchimedes 26-01-2022 8 0   Download

Prime editing is a revolutionary genome-editing technology that can make a wide range of precise edits in DNA. However, designing highly efficient prime editors (PEs) remains challenging. We develop Easy-Prime, a machine learning–based program trained with multiple published data sources.

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Articles in this volume are based on talks given at the Gauss-Dirichlet Conference held on June 20-24, 2005. The conference commemorated the 150th anniversary of the death of C.-F. Gauss and the 200th anniversary of the birth of J.-L. Dirichlet. The volume begins with a definitive summary of the life and work of Dirichlet and continues with thirteen papers by leading experts on research topics of current interest in number theory that were directly influenced by Gauss and Dirichlet.

266p beobobeo 01-08-2012 67 12   Download

Hindawi Publishing Corporation Journal of Inequalities and Applications Volume 2011, Article ID 131240, 14 pages doi:10.1155/2011/131240 Research Article Size of Convergence Domains for Generalized Hausdorff Prime Matrices T. Selmanogullari,1 E. Savas,2 and B. E. Rhoades3 ¸ 1 2 Department of Mathematics, Mimar Sinan Fine Arts University, Besiktas, 34349 Istanbul, Turkey Department of Mathematics, Istanbul Commerce University, Uskudar, 34672 Istanbul, Turkey 3 Department of Mathematics, Indiana University, Bloomington, IN 47405-7106, USA Correspondence should be addressed to T.

14p dauphong13 09-02-2012 54 6   Download