Prior skeleton

The continual reassessment method (CRM) identifies the maximum tolerated dose (MTD) more efficiently and identifies the true MTD more frequently compared to standard methods such as the 3 + 3 method. An initial estimate of the dose-toxicity relationship (prior skeleton) is required, and there is limited guidance on how to select this.

10p vichaeng2711 29-04-2021 24 1   Download

The continual reassessment method (CRM) requires an underlying model of the dose-toxicity relationship (“prior skeleton”) and there is limited guidance of what this should be when little is known about this association. In this manuscript the impact of applying the CRM with different prior skeleton approaches and the 3 + 3 method are compared in terms of ability to determine the true maximum tolerated dose (MTD) and number of patients allocated to sub-optimal and toxic doses.

12p vimale2711 25-08-2020 11 2   Download

It is the responsibility of the Project Manager to schedule standing Project Board meetings at the beginning of the project. Confirm the logistics of the next meeting, namely date, time and conference room. Create the meeting agenda. It is recommended that you use the Word 6.0 Agenda Wizard (standard style) to create the agenda. This Wizard also creates the skeleton meeting minutes. Confirm the agenda with the Project Sponsor. Assemble any additional documentation that requires reading as preparation for the Project Board meeting.

31p tainhacmienphi 25-02-2013 67 9   Download

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386p meojunior 03-12-2010 117 29   Download