PRMT5 inhibitor
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Inhibitors of Poly (ADP-Ribose) Polymerases (PARP) provide clinical benefit to patients with breast and ovarian cancers, by compromising the DNA repair activity of cancer cells. Although these agents extend progressionfree survival in many patients, responses can be short lived with many patients ultimately progressing.
14p vioracle 29-09-2023 4 2 Download
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MYC amplification or overexpression is common in Group 3 medulloblastoma and is associated with the worst prognosis. Recently, protein arginine methyl transferase (PRMT) 5 expression has been closely associated with aberrant MYC function in various cancers, including brain tumors such as glioblastoma.
11p vikuala271 13-06-2020 8 1 Download