Programmed cell death

Ovarian cancer (OC) is a gynecological malignancy tumor with high recurrence and mortality rates. Programmed cell death (PCD) is an essential regulator in cancer metabolism, whose functions are still unknown in OC. Therefore, it is vital to determine the prognostic value and therapy response of PCD-related genes in OC.

17p vishanshan 27-06-2024 1 1   Download

PANoptosis is a specific type of inflammatory programmed cell death (PCD) modality that can be involved in three key modes of cellular programmed cell death-pyroptosis, apoptosis and necroptosis.

13p vishanshan 27-06-2024 1 1   Download

Pyroptosis is a type of programmed cell death mediated by the gasdermin family. Gasdermin B (GSDMB), as a member of gasdermin family, can promote the occurrence of cell pyroptosis. However, the correlations of the GSDMB expression in colorectal cancer with clinicopathological predictors, immune microenvironment, and prognosis are unclear.

13p vishanshan 27-06-2024 1 1   Download

Combination therapy is the primary treatment for unresectable hepatocellular carcinoma (u-HCC). The hepatic functional reserve is also critical in the treatment of HCC. In this study, u-HCC was treated with combined hepatic arterial infusion chemotherapy (HAIC), tyrosine kinase inhibitors (TKIs), and programmed cell death protein-1 (PD-1) inhibitors to analyze the therapeutic response, progression-free survival (PFS), and safety.

10p vishanshan 27-06-2024 2 1   Download

Many randomized controlled trials (RCTs) and network meta-analyses have demonstrated that the progression-free survival (PFS) and overall survival (OS) of advanced non-small cell lung cancer (NSCLC) patients can be improved through combination immunotherapy or monotherapies.

9p vikoch 27-06-2024 1 1   Download

Ebook "Necrotic cell death" presents comprehensive coverage of necrosis from recognized experts from leading academic and medical institutions around the world. ​In contrast to apoptosis, well-defined as a form of programmed cell death, necrosis used to be considered as accidental (i.e., non-programmed) cell death, usually in response to a severe injury. Accumulating evidence now suggests, however, that necrosis is also programmed and controlled by distinctive "death machinery" in response to various stimuli like oxidative stress or DNA damage.

402p ladongphongthanh1008 22-04-2024 3 1   Download

Ebook "Acute neuronal injury: The role of excitotoxic programmed cell death mechanisms" is the result of a convergence of scientific information regarding mechanisms that produce acute nerve cell death in the brain.

303p tracanhphuonghoa1007 22-04-2024 4 3   Download

Immune checkpoint blockade (ICB) therapies, which potentiate the body’s natural immune response against tumor cells, have shown immense promise in the treatment of various cancers. Currently, tumor mutational burden (TMB) and programmed death ligand 1 (PD-L1) expression are the primary biomarkers evaluated for clinical management of cancer patients across histologies.

18p vibransone 28-03-2024 6 1   Download

Immune checkpoint blockade (ICB) with antibodies inhibiting cytotoxic T lymphocyte-associated protein-4 (CTLA-4) and programmed cell death protein-1 (PD-1) (or its ligand (PD-L1)) can stimulate immune responses against cancer and have revolutionized the treatment of tumors.

13p vibransone 28-03-2024 8 2   Download

Ebook "Programmed cell death in cancer progression and therapy (Advances in experimental medicine and biology, Volume 615)" give a comprehensive overview of the mechanisms that are involved in mediating and regulating PCD in cancer. We also provide a detailed indication of the utility of PCD in cancer therapy. This book will be a valuable resource for researchers investigating the role of PCD in cancer and other diseases, researchers investigating the molecular mechanism of chemotherapeutic agents and drug-resistance in cancer and for physicians using chemotherapeutic agents.

362p duongthandue0501 28-02-2024 1 1   Download

Ebook "Cell death: Mechanism and disease" provides a comprehensive view of cell death, from its mechanisms of initiation and execution, to its implication in human disease and therapy. Physiological cell death plays critical roles in almost all aspects of biology, and the book details its roles in lymphocyte homeostasis, neuronal function, metabolism, and the DNA damage response. When physiological cell death goes awry, diseases can arise, and cancer is presented as a central paradigm for the consequences of derangements in the interplay between cell survival and cell death.

280p manmanthanhla0201 26-02-2024 2 1   Download

Ebook "Nutrient use efficiency in plants: Concepts and approaches" presents a broad overview of topics related to improvement of nutrient use efficiency of crops. Nutrient use efficiency (NUE) is a measure of how well plants use the available mineral nutrients. It can be defined as yield (biomass) per unit input (fertilizer, nutrient content). NUE is a complex trait: it depends on the ability to take up the nutrients from the soil, but also on transport, storage, mobilization, usage within the plant, and even on the environment.

287p manmanthanhla0201 26-02-2024 3 1   Download

Ebook Developmental neurobiology: Part 2 includes content: Cell determination and early differentiation, neuronal survival and programmed cell death, synaptic formation and reorganization,…and other contents.

199p longtimenosee03 01-02-2024 4 0   Download

Mononeuritis multiplex is a rare autoimmune peripheral neuropathy that typically presents in the context of vasculitis, diabetes, infection, or as a paraneoplastic syndrome. Adverse immune-related neurological conditions have been increasingly reported with the use of immune checkpoint inhibitors against cytotoxic T-lymphocyte antigen-4 and/or the programmed cell death protein 1/programmed death ligand-1 axis.

5p vitiki 30-01-2024 8 2   Download

Ebook "Microbial stress tolerance for biofuels: Systems biology" provides an overview of methods for studying microbial stress tolerance for biofuels applications using a systems biology approach. Topics covered range from mechanisms to methodology for yeast and bacteria, including the genomics of yeast tolerance and detoxification; genetics and regulation of glycogen and trehalose metabolism; programmed cell death; high gravity fermentations;...

311p tachieuhoa 28-01-2024 4 2   Download

Part 3 book "Textbook of biochemistry - With clinical correlations" includes content: Lipid metabolism II - pathways of metabolism of special lipids; amino acid and heme metabolism; purine and pyrimidine nucleotide metabolism; metabolic interrelationships; biochemistry of hormones; molecular cell biology; cell cycle, programmed cell death and cancer; digestion and absorption of basic nutritional constituents; vitamins and minerals - requirements and function; macronutrients - metabolic effects and health implications.

501p muasambanhan04 07-01-2024 2 1   Download

Ebook "Xylem: Methods and protocols" provides detailed techniques used for the study and characterization of the plant vascular system, with a central focus on the xylem tissue. Chapters are organized in three main sections covering; analysis of xylem development, xylem characterization though imaging techniques, and analysis of the xylem composition.

257p lucchinguyen 28-12-2023 8 2   Download

Immune checkpoint inhibitors, including PD-L1 (programmed death ligand-1) inhibitors have well documented anticancer therapeutic effects in most types of cancers but its use in the treatment of ovarian cancer is not yet proven. The aim of our study is to explore the predictive biomarkers in ovarian cancer and its association with the outcomes.

16p vileonardodavinci 23-12-2023 3 2   Download

Biomarkers that can accurately predict the efcacy of immune checkpoint inhibitors (ICIs) against programmed death 1 (PD-1) ligand in cancer immunotherapy are urgently needed. We have previously reported a novel formula that predicts the response to treatment with second-line nivolumab with high sensitivity and specificity in patients with non-small cell lung cancer (NSCLC) previously treated with chemotherapy.

10p vileonardodavinci 23-12-2023 4 3   Download

Cuproptosis, a new form of programmed cell death, has been recently reported to be closely related to tumor progression. However, the significance of cuproptosis-related genes (CRGs) in papillary thyroid carcinoma (PTC) is still unclear. Therefore, this study aimed to investigate the role of the CRG signature in prognosis prediction and immunotherapeutic effect estimation in patients with PTC.

17p vileonardodavinci 23-12-2023 3 3   Download