Prohibitin

Prohibitin (PHB-1) is a highly conserved protein involved in mitochondrial biogenesis and function. It is secreted in lipid droplets from adipocytes and is present in the circulation. In adipose tissue it functions as a membrane receptor and can target binding partners to the mitochondria.

9p dell39 27-03-2013 40 5   Download

Prohibitin-1 (PHB, also known as PHB1), a member of the Band-7 family of proteins, is highly conserved evolutionarily, widely expressed, and pres-ent in different cellular compartments. Genetic studies with different organ-ism models have provided strong evidence for an important biological role of PHB in mitochondrial function, cell proliferation, and development.

10p viettel02 19-02-2013 37 3   Download

Pancreaticb-cell dysfunction is a prerequisite for the development of type 2 diabetes. Alcoholism is a diabetes risk factor and ethanol increases oxida-tive stress in b-cells, whereas the mitochondrial chaperone prohibitin (PHB) has antioxidant effects in several cell types.

13p mobifone23 18-01-2013 37 4   Download