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Protease activated receptors
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Breast cancer comprises clinically and molecularly distinct tumor subgroups that differ in cell histology and biology and show divergent clinical phenotypes that impede phase III trials, such as those utilizing cathepsin K inhibitors.
19p
vinaypyidaw2711
26-08-2020
10
1
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Protease activated receptor (PAR)-1 expression is increased in a variety of tumor cells. In preclinical models, tumor cell PAR-1 appeared to be involved in the regulation of lung tumor growth and metastasis; however the role of PAR-1 in the lung tumor microenvironment, which is emerging as a key compartment in driving cancer progression, remained to be explored.
8p
vimale2711
21-08-2020
12
2
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Our laboratory showed that bikunin, aKunitz-type protease inhibitor, suppresses 4b-phorbol 12-myristate 13-acetate (PMA)- or tumor necrosis factor-alpha (TNFa)-induced urokinase-type plasminogen activator (uPA) expression in different cell types. In addition to its effects on protease inhibition, bikunincouldbemodulatingother cellular events associated with the metastatic cascade.
13p
research12
23-04-2013
40
1
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Platelet activation by thrombin plays a major role in the development of haemostasis and thrombosis. Thrombin activates human platelets by cleaving the N-terminal region of G-protein-coupled protease-activated receptors (PARs). On the other hand, the platelet membrane glycoprotein GPIb acts as a thrombin-binding site and promotes platelet activation by low thrombin concentrations.We present here new evidence in favour of a thrombin receptor function for GPIb. We have selected conditions in which thrombin– GPIb interactions were enhanced by thrombin immobiliza-tion....
12p
fptmusic
16-04-2013
26
1
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Exposure of blood to tissue factor (TF) rapidly initiates the coagulation serine protease cascades. TF is expressed by macrophages and other types of cell within atherosclerotic lesions and plays an important role in throm-bus formation after plaque rupture. Macrophage TF expression is induced by pro-inflammatory stimuli including lipopolysaccharide (LPS), inter-leukin-1band tumor necrosis factor-a. Here we demonstrate that activation of liver X receptors (LXRs) LXRaand LXRbsuppresses TF expression....
11p
awards
06-04-2013
43
2
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Chronic obstructive pulmonary disease is a major clinical disorder usually associated with cigarette smoking. A central feature of chronic obstructive pulmonary disease is inflammation coexisting with an abnormal protease/anti-protease balance, leading to apoptosis and elastolysis. In anin vitro study of rat lung alveolar L2 cells, cigarette smoke extract (CSE) induced apoptotic cell death. Expo-sure of L2 cells to CSE at a concentration of 0.25% resulted in a 50% increase of caspase-3 and matrix met-alloproteinase (MMP) activities.
11p
dell39
03-04-2013
51
2
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Human airway trypsin-like protease (HAT), a serine protease found in the sputum of patients with chronic airway diseases, is an agonist of protease-activated receptor-2 (PAR-2). Previous results have shown that HAT enhances the release of amphiregulin (AR); further, it causes MUC5AC gene expression through the AR-epidermal growth factor receptor pathway in the airway epithelial cell line NCI-H292.
13p
dell39
27-03-2013
32
1
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Many cellular functions of lung fibroblasts are controlled by protease-acti-vated receptors (PARs). In fibrotic diseases, PAR-1 plays a major role in controlling fibroproliferative and inflammatory responses. Therefore, in these diseases, regulation of PAR-1 expression plays an important role.
11p
galaxyss3
07-03-2013
33
2
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Toll-like receptors and RNA helicase family members [retinoic acid-inducible gene I (RIG-I) and melanoma differentiation associated gene-5 (MDA5)] play important roles in the induction of interferon-bas a major event in innate immune responses after virus infection. TRIF (adaptor pro-tein of Toll-like receptor 3)-mediated and Cardif (adaptor protein of RIG-I or MDA5)-mediated signaling pathways contribute rapid induction of interferon-bthrough the activation of interferon regulatory factor-3 (IRF-3)....
16p
media19
04-03-2013
34
1
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Hepatocyte growth factor activator (HGFA) is a serine protease initially identified as a potent activator of hepatocyte growth factor⁄scatter factor. Hepatocyte growth factor⁄scatter factor is known to be critically involved in tissue morphogenesis, regeneration, and tumor progression, via its recep-tor, MET. In vivo, HGFA also activates macrophage-stimulating protein, which has roles in macrophage recruitment and inflammatory processes, cellular survival and wound healing through its receptor, RON....
8p
mobifone23
21-01-2013
32
3
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Role of protease-activated receptor-2 on cell death and DNA fragmentation in Helicobacter pylori-infected gastric epithelial cells
7p
dauphong4
03-01-2012
33
3
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: To be or not to be protease activated receptor-1 in activated protein C-initiated endothelial barrier protection?
2p
coxanh_3
25-10-2011
52
6
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Protease-activated receptor 2 activation of myeloid dendritic cells regulates allergic airway inflammation...
14p
toshiba11
20-10-2011
44
3
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Mucosal sensitization to German cockroach involves protease-activated receptor-2...
10p
toshiba11
19-10-2011
40
3
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Essential role of platelet activation via protease activated receptor 4 in tissue factor-initiated inflammation...
8p
thulanh14
15-10-2011
69
2
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Integration of cell death responses. Cell death through an apoptotic mechanism requires active participation of the cell. In response to interruption of growth factor (GF) or propagation of certain cytokine death signals (e.g., tumor necrosis factor receptor, TNF-R), there is activation of "upstream" cysteine aspartyl proteases (caspases), which then directly digest cytoplasmic and nuclear proteins, resulting in activation of "downstream" caspases; these cause activation of nucleases, resulting in the characteristic DNA fragmentation that is a hallmark of apoptosis. ...
5p
konheokonmummim
03-12-2010
52
3
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