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Protein abundances
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Ebook "Heat shock proteins in neural cells" address the role of heat shock proteins and cellular stress responses in the brain, with a major focus on nerve cells and glia, namely oligodendrocytes and astrocytes. Chapter 1 summarizes the classification and functional roles of heat shock proteins which are particularly abundant in brain cells.
123p
tracanhphuonghoa1007
22-04-2024
1
1
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PTEN is a multi-functional tumor suppressor protein regulating cell growth, immune signaling, neuronal function, and genome stability. Experimental characterization can help guide the clinical interpretation of the thousands of germline or somatic PTEN variants observed in patients.
17p
vibransone
28-03-2024
1
1
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Part 2 book "Farm animal proteomics 2013" includes content: Biomarkers of winter disease in gilthead seabream - a proteomics approach, the absorption of colostral proteins in newborn lambs - an iTRAQ proteomics study, plasma proteome profiles predict diet-induced metabolic syndrome and the early onset of metabolic syndrome in a pig model, changes in protein abundance in the vertebral columnof, atlantic salmon (Salmosalar) fed variable dietary P levels,... and other contents.
129p
muasambanhan02
18-12-2023
1
0
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Neuropeptide Y (NPY) is an abundant neurohormone in human breast carcinomas that acts on a class of G-protein coupled receptors, of which NPY1R and NPY5R are the most highly expressed. This abundance is exploited for cancer imaging, but there is interest in pharmacological inhibition of the NPYRs to interrogate their functional relevance in breast cancer.
15p
visharma
20-10-2023
3
2
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The main aim of this research work was to characterize the late embryogenesis abundant (LEA) protein families and to carry out gene expression analysis to determine their potential role in drought stress tolerance in upland cotton.
31p
vinarcissa
21-03-2023
2
2
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MYB family proteins are one of the most abundant transcription factors in the cotton plant and play diverse roles in cotton growth and evolution. Previously, few studies have been conducted in upland cotton, Gossypium hirsutum. The recent release of the G. hirsutum genome sequence provides a great opportunity to identify and characterize the entire upland cotton MYB protein family.
12p
vinarcissa
21-03-2023
3
1
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Intramuscular fat (IMF) content is an important factor in porcine meat quality. Previously, we showed that miR-34a was less abundant in liver tissue from pigs with higher backfat thickness, compared to pigs with lower backfat thickness. The purpose of this present study was to explore the role of miR-34a in adipogenesis.
11p
vihagrid
30-01-2023
7
3
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Plants are advantageous as biopharmaceutical manufacturing platforms because they allow the economical and scalable upstream production of proteins, including those requiring post-translational modifications, but do not support the replication of human viruses. However, downstream processing can be more labor-intensive compared to fermenter-based systems because the product is often mixed with abundant host cell proteins.
13p
viginny
23-12-2022
9
3
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Equine endometrosis is a chronic degenerative condition, described as endometrial fibrosis that forms in the stroma, under the basement membrane and around the endometrial glands. The role of lysophosphatidic acid (LPA) in the development of tissue fibrosis varies depending on the organ, and its profibrotic role in mare endometrosis remains unclear.
13p
vigandhi
23-02-2022
26
1
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Piwi-interacting RNAs (piRNAs) are a class of short (~26–31-nucleotide) non-protein-coding RNAs expressed in the metazoan germline. The piRNA pathway in arthropods is best understood in the ovary of Drosophila melanogaster, where it acts to silence active transposable elements (TEs).
16p
vialfrednobel
29-01-2022
5
0
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About 11% of all human genetic diseases are caused by nonsense mutations that generate premature translation termination codons (PTCs) in messenger RNAs (mRNA). PTCs not only lead to the production of truncated proteins, but also often result in decreased mRNA abundance due to nonsense-mediated mRNA decay (NMD).
16p
vialfrednobel
29-01-2022
12
0
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Next-generation sequencing has generated a need for a broadly applicable method to remove unwanted highabundance species prior to sequencing. We introduce DASH (Depletion of Abundant Sequences by Hybridization). Sequencing libraries are ‘DASHed’ with recombinant Cas9 protein complexed with a library of guide RNAs targeting unwanted species for cleavage, thus preventing them from consuming sequencing space.
13p
viaristotle
29-01-2022
9
0
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Soluble protein and lipid mediators play essential roles in the tumor environment, but their cellular origins, targets, and clinical relevance are only partially known. We have addressed this question for the most abundant cell types in human ovarian carcinoma ascites, namely tumor cells and tumor-associated macrophages.
22p
viaristotle
29-01-2022
4
0
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RNA editing generates modifications to the RNA sequences, thereby increasing protein diversity and shaping various layers of gene regulation. Recent studies have revealed global shifts in editing levels across many cancer types, as well as a few specific mechanisms implicating individual sites in tumorigenesis or metastasis.
25p
viarchimedes
26-01-2022
9
0
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The speed of translation elongation is primarily determined by the abundance of tRNAs. Thus, the codon usage influences the rate with which individual mRNAs are translated. As the nature of tRNA pools and modifications can vary across biological conditions, codon elongation rates may also vary, leading to fluctuations in the protein production from individual mRNAs.
20p
viarchimedes
26-01-2022
8
1
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The simultaneous quantification of protein and RNA makes possible the inference of past, present, and future cell states from single experimental snapshots. To enable such temporal analysis from multimodal single-cell experiments, we introduce an extension of the RNA velocity method that leverages estimates of unprocessed transcript and protein abundances to extrapolate cell states.
6p
viarchimedes
26-01-2022
10
0
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We investigated the effect of endoplasmic reticulum (ER) protein 29 (ERp29) on thyroglobulin (Tg) secretion and its negative regulation by microRNAs (miRNAs). ERp29 overexpression promoted Tg secretion from thyrocytes of PCCL3 cells via activation of ER stress sensors, including activation of transcription factor 6 fragmentation, XBP1 mRNA splicing by inositol-requiring enzyme 1, and phosphorylation of eukaryotic initiation factor 2 alpha as downstream actions of RNA-dependent protein kinase-like ER kinase.
6p
dolomite36
30-12-2021
10
0
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The aim of this work is to valorise the species Ammodaucus leucotrichus Coss which is known by its abundance in perillaldehyde. The plant material was collected from two regions in Morocco: Errachidia and Smara region, then was hydrodistilled. The essential oils (EOs) obtained were firstly characterized by gas chromatography coupled to mass spectrometry (GC-MS). Secondly the EO with the major component is the perillaldehyde was used as starting material to semi-synthesize three p-menthane monoterpenoids.
6p
mudbound
10-12-2021
7
1
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Hepatocellular carcinoma (HCC) is a common cause of cancer mortality worldwide. Recent studies have shown that the polytopic enzyme membrane associated ring-CH-type finger 6 (MARCH6) participates in tumorigenesis, but its function in HCC development needs to be investigated. This study aimed to explore the role of MARCH6 in HCC.
11p
vimahuateng
26-11-2021
4
1
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Heterogeneous nuclear ribonucleoprotein (HNRNP) A1 and A2 are the most abundant HNRNPs with nearly identical functions, and play important roles in regulating gene expression at multiple levels (i.e. transcription, posttranscription, and translation). However, the expression and regulation mechanism of HNRNPA1 and A2 themselves remain unclear. In this study, the amino acid sequences of HNRNPA1 and HNRNPA2 were compared and found to have 78% and 86% homology in key functional domains.
10p
thiencuuchu
27-11-2021
9
1
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