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Protein cavities
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Extracellular vesicles (EVs) have been revealed to facilitate the development of oral squamous cavity cell carcinoma (OCSCC), while its supporting role in lymph node metastases is under continuous investigation. This study aimed to examine the function of cancer-associated fibroblasts (CAF)-derived EVs (CAF-EVs) during lymph node metastasis in OCSCC and the mechanisms.
13p
vikoch
27-06-2024
2
1
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Dogs’ saliva is a complex mixture of inorganic and organic constituents, rich in proteins. Therefore, knowing the saliva composition of these animals is extremely important to identify the presence of proteins that may be involved in physiological and pathological mechanisms of their oral cavity.
12p
vigandhi
23-02-2022
9
1
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The characterization of protein binding sites is a major challenge in computational biology. Proteins interact with a wide variety of molecules and understanding of such complex interactions is essential to gain deeper knowledge of protein function.
8p
vikentucky2711
26-11-2020
10
0
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Identifying druggable cavities on a protein surface is a crucial step in structure based drug design. The cavities have to present suitable size and shape, as well as appropriate chemical complementarity with ligands.
15p
vikentucky2711
24-11-2020
11
1
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Voids and cavities in the native protein structure determine the pressure unfolding of proteins. In addition, the volume changes due to the interaction of newly exposed atoms with solvent upon protein unfolding also contribute to the pressure unfolding of proteins.
6p
vikentucky2711
24-11-2020
16
1
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Protein cavities play a key role in biomolecular recognition and function, particularly in protein-ligand interactions, as usual in drug discovery and design. Grid-based cavity detection methods aim at finding cavities as aggregates of grid nodes outside the molecule, under the condition that such cavities are bracketed by nodes on the molecule surface along a set of directions (not necessarily aligned with coordinate axes).
10p
viconnecticut2711
29-10-2020
16
2
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Humans and dogs are affected by squamous cell carcinomas of the oral cavity (OSCC) in a considerably high frequency. The high mobility group A2 (HMGA2) protein was found to be highly expressed in human OSCC and its expression was suggested to act as a useful predictive and prognostic tool in clinical management of oral carcinomas.
11p
vilisa271
22-09-2020
13
0
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The EGFR and downstream signaling pathways play an important role in tumorigenesis in oral squamous cell carcinoma (OSCC). Gene copy number alteration is one mechanism for overexpressing the EGFR protein and was also demonstrated to be related to lymph node metastasis, tumor invasiveness and perineural invasion.
9p
vidhaka2711
31-07-2020
14
2
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This study examined the prognostic significance of microtubule-associated protein light chain 3B (LC3B) expression in oropharyngeal and oral cavity squamous cell carcinoma (SCC). The prognostic significance of LC3B expression in relation to human papillomavirus (HPV) status in oropharyngeal SCC was also examined.
12p
vibaku2711
22-07-2020
10
2
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This study examined the prognostic significance of microtubule-associated protein light chain 3B (LC3B) expression in oropharyngeal and oral cavity squamous cell carcinoma (SCC).
12p
vibaku2711
22-07-2020
12
1
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Nuclear protein in testis (NUT) carcinoma (NC) is a rare epithelial malignancy characterized by rearrangement of the NUT gene on chromosome 15. If NC is not suspected, it is often diagnosed as other malignancies.
6p
vimanila2711
25-06-2020
9
0
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An experiment was carried in Horticultural College and Research Institute, Periyakulam, during 2017.The observation were recorded on the following traits, vine length, node at which first female flower appears, days to appearance of first female flower, number of female flowers per vine, days to first fruit harvest, number of fruits per vine, sex ratio, fruit yield per vine, fruit length, average fruit weight, fruit width, fruit cavity, flesh thickness, total soluble solids, protein, ascorbic acid, iron and momordicine content.
7p
nguaconbaynhay6
23-06-2020
13
0
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Human saliva plays a pivotal role in digesting food and maintaining oral hygiene. The presence of electrolytes, mucus, glycoproteins, enzymes, antibacterial compounds, and gingival crevicular fluid in saliva ensures the optimum condition of oral cavity and general health condition. Saliva collection has been proven non-invasive, convenient, and inexpensive compared to conventional venipuncture procedure.
7p
viwashington2711
04-12-2019
6
1
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Ecdysteroids are hormones with an important role in the molting, reproduction and immunological defense of arthropods. Ecdysone Receptor (EcR) is a protein that belongs to the superfamily of nuclear receptors, widely studied for pesticide discovery. Currently, several non-steroidal molecules, belonging to the chemical group of diacilhydrazines (DAH), are commercially available for pest control. Such molecules are specific for lepidopteran or coleopteran pests. Hemipterans are important pests in most crops and many cases of pesticide resistance are reported.
10p
chauchaungayxua1
04-12-2019
14
1
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A molecular understanding of volatile anesthetic mechanisms of action will require structural descriptions of anesthetic–protein complexes. Porcine odorant binding protein is a 157 residue member of the lipocalin family that features a large b-barrel internal cavity (515 ± 30 A ˚ 3 ) lined predomin-antly by aromatic and aliphatic residues. Halothane binding to theb-barrel cavity was determined using fluorescence quenching of Trp16, and a com-petitive binding assay with 1-aminoanthracene.
0p
awards
05-04-2013
16
1
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The available literature implicating human monoamine oxidase A (MAO A) in apoptotic processes reports levels of MAO A protein that do not corre-late with activity, suggesting that unknown mechanisms may be involved in the regulation of catalytic function.
13p
vinaphone15
25-02-2013
39
2
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The first function, sperm cell formation, occurs in the two testes. The formation of sperm requires a temperature that is a few degrees cooler than the temperature of the rest of the body. How is this temperature reduction produced? The testes are suspended within a sac called the scrotum. Because it is not located within the body cavity, the temperature of the scrotum is a few degrees lower than normal body temperature. The scrotum is an adaptation that has evolved to increase the chances of pro- ducing healthy sperm. Inside the testes are a great many tiny tubes, or tubules.
19p
ut_hai_can
25-12-2012
41
5
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