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Protein folding
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Ebook "Protein folding and misfolding: Neurodegenerative diseases" is to review the molecular events initiated by unfolded or misfolded proteins leading to cell death via the development of pathological inclusions, with special emphasis on the macromolecular associations of the malfolded proteins into characteristic ultrastructures found in the cases of neurological disorders, some of them are shown in this issue.
284p
ladongphongthanh1008
22-04-2024
3
2
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Ebook "CtBP family proteins" are unique in several aspects. They were the first among proteins containing a metabolic enzyme fold to be implicated in transcriptional regulation. The vertebrate CtBPs exhibit distinct nuclear and cytosolic activities. The crystal struaures of CtBPl and molecular modeling studies have illuminated the molecular basis of its dual activity and the interaction with target peptides.
131p
ladongphongthanh1008
22-04-2024
5
2
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Ebook "Folding for the synapse" addresses the current view on how protein folding and misfolding, controlled by molecular chaperones, contribute to synapse function and dysfunction. Molecular chaperones have been studied in relation to de novo protein folding, but there is increasing awareness that chaperone function is required for the regulation of protein dynamics when functioning physiologically as an isolated moiety or part of a protein complex.
315p
tracanhphuonghoa1007
22-04-2024
3
2
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Ebook "Mitochondria and cell death" examines the role of mitochondria in different types of cell death, including apoptotic and necrotic cell deaths. Topics discussed include mitochondrial outer membrane permeabilization (MOMP) and the permeability transition pore; core processes such as calcium handling, fission and fusion, reactive oxygen species generation, and maintenance of mitochondrial DNA fidelity and protein folding homeostasis; and retrograde signaling between mitochondria and other cellular components, including the important role of mitochondria in antiviral immunity.
242p
tracanhphuonghoa1007
22-04-2024
2
2
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In ebook "Single-molecule fluorescence spectroscopy of the folding of a repeat protein" single-molecule fluorescence resonance energy transfer (FRET) spectroscopy was used to study the folding of a protein that belongs to the large and important family of repeat proteins. Cohen shows that the dynamics of the expanded conformations is likely to be very fast, suggesting a spring-like motion of the whole chain. The findings shed new light on the elasticity of structure in repeat proteins, which is related to their function in binding multiple and disparate partners.
70p
tracanhphuonghoa1007
22-04-2024
4
3
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The IRE1a-XBP1 pathway is a conserved adaptive mediator of the unfolded protein response. The pathway is indispensable for the development of secretory cells by facilitating protein folding and enhancing secretory capacity.
19p
vibransone
28-03-2024
5
2
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Ebook "Molecular chaperones (Topics in Current chemistry, 328)" describes all three families of known peptidyl prolyl isomerases (PPIases) including the FKBPs, cyclophilins and parvulins. These chaperones catalyse conformational interconversions of peptide bonds which can be critical to the correct folding of many proteins. The structural and chemical features of PPIases and the catalytic cycle are described, and a discussion of chaperoning versus catalysis is also included.
281p
coduathanh1122
27-03-2024
5
1
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Ebook "Protein folding kinetics: Biophysical methods (2nd edition)" gives a deep insight into the principles and concepts of the kinetic and structural resolution of fast chemical and biophysical reactions of proteins with emphasis on protein-folding reactions. The study of fast protein-folding reactions and the understanding of the folding paradox have significantly advanced due to the recent development of new biophysical methods which allow not only kinetic resolution in the sub-millisecond time scale but also structural resolution with unprecedented precision.
228p
tachieuhoa
28-01-2024
3
2
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Ebook "Reviews in fluorescence 2009" topics include: hot electron-induced electrogenerated chemiluminescence; time-correlated, single-photon counting methods in endothelial cell mechanobiology; origin of tryptophan fluorescence; protein folding, unfolding and aggregation processes revealed by rapid sampling of time-domain fluorescence.
395p
tachieuhoa
28-01-2024
3
2
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The effects of inert spherical crowders on the melting temperature and the folding stability of small globular proteins are investigated by using molecular dynamics simulations with a Go-like model for the proteins.
10p
vispiderman
15-06-2023
3
2
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G-protein subunit beta 1 like (GNB1L) encodes a G-protein beta-subunit-like polypeptide. Chicken GNB1L is upregulated in the breast muscle of high feed efficiency chickens, and its expression is 1.52-fold that in low feed efficiency chickens. However, no report has described the effects of GNB1L indels on the chicken carcass and growth traits.
7p
vihagrid
30-01-2023
6
3
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Quantitative principles of cis-translational control by general mRNA sequence features in eukaryotes
General translational cis-elements are present in the mRNAs of all genes and affect the recruitment, assembly, and progress of preinitiation complexes and the ribosome under many physiological states. These elements include mRNA folding, upstream open reading frames, specific nucleotides flanking the initiating AUG codon, protein coding sequence length, and codon usage.
24p
vielonmusk
30-01-2022
16
2
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The ocean microbiome represents one of the largest microbiomes and produces nearly half of the primary energy on the planet through photosynthesis or chemosynthesis. Using recent advances in marine genomics, we explore new applications of oceanic metagenomes for protein structure and function prediction.
14p
vielonmusk
30-01-2022
10
0
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The three-dimensional (3D) organization of chromosomes can be probed using methods like Capture-C. However, it is unclear how such population-level data relate to the organization within a single cell, and the mechanisms leading to the observed interactions are still largely obscure. We present a polymer modeling scheme based on the assumption that chromosome architecture is maintained by protein bridges, which form chromatin loops.
16p
viaristotle
29-01-2022
17
1
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The folding of proteins is challenging in the highly crowded and sticky environment of a cell. Regulation of translation elongation may play a crucial role in ensuring the correct folding of proteins. Much of our knowledge regarding translation elongation comes from the sequencing of mRNA fragments protected by single ribosomes by ribo-seq.
35p
viarchimedes
26-01-2022
7
0
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mRNA can form local secondary structure within the protein-coding sequence, and the strength of this structure is thought to influence gene expression regulation. Previous studies suggest that secondary structure strength may be maintained under selection, but the details of this phenomenon are not well understood.
20p
viarchimedes
26-01-2022
12
0
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Thioredoxin reductase (E.C 1.6.4.5.; TrxR) is an enzyme belonging to the flavoprotein family of pyridine nucleotide-disulfide oxidoreductases. In this study, mitochondrial TrxR enzyme was purified from rainbow trout mitochondria. Thanks to the 2 consecutive procedures (preparation of homogenate and 2’,5’-ADP Sepharose 4B affinity chromatography), the enzyme, having the specific activity of 11.9 EU mg protein-1, was purified with a yield of 2.38% and 672-fold. The purity of the enzyme was monitored and the molecular weight of its subunits was calculated as 70 kDa by SDS-PAGE.
10p
langthannam
29-12-2021
9
0
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The thioredoxin system, found in all living creatures, consists of thioredoxin protein (Trx), thioredoxin reductase enzyme (TrxR), and NADPH. In this study, turkey liver mitochondrial TrxR enzyme with 3.07 EU × mg −1 specific activity was purified 990-fold in a yield of 2.05% using 2’,5’-ADP Sepharose 4B affinity chromatography. The purity of the enzyme was measured and the molecular weight of its subunits was determined to be 45.5 kDa by SDSPAGE. The molecular mass of the enzyme’s natural state was found to be 88 kDa using Sephadex-G 150 gel filtration chromatography.
13p
langthannam
29-12-2021
10
0
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In this paper, antidiabetic activities of glucomanno-oligosaccharides (GMO) were in vitro and in vivo investigated. Treatment with 100 μg/ml and 50 μg/ml of GMO for 1 hour caused 1.47-fold and 1.81-fold phosphorylation of AMPK, respectively. Oral administration of GMO (6 g/kg-1 of body weight day-1 ) lowered blood glucose levels (p < 0.05) at 120 min as compared to control group. These results suggested that GMO exhibited anti-diabetic effects via activation of AMPK and could be useful for diabetes prevention.
6p
spiritedaway36
25-11-2021
4
0
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Protein disulfide isomerase (PDI) and PDI-like proteins contain thioredoxin domains that catalyze protein disulfide bond, inhibit aggregation of misfolded proteins, and function in isomerization during protein folding in endoplasmic reticulum and responses during abiotic stresses.Chinese cabbage is widely recognized as an economically important, nutritious vegetable, but its yield is severely hampered by various biotic and abiotic stresses. Because of, it is prime need to identify those genes whose are responsible for biotic and abiotic stress tolerance. PDI family genes are among of them.
20p
vilarryellison
29-10-2021
7
1
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