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Protein multimerization
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Ebook "RNA exosome" is arising as a major facilitator to this effect. Structural and functional data gathered over the last decade have illustrated the biochemical importance of this multimeric complex and its many co-factors, revealing its enormous regulatory power. By gathering some of the most prominent researchers in the exosome field, it is the aim of this volume to introduce this fascinating protein complex as well as to give a timely and rich account of its many functions.
161p
cotieubac1004
15-03-2024
1
0
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Phosphorylation is one of the most important post-translational modifications (PTM) employed by cells to regulate several cellular processes. Studying the effects of phosphorylations on protein structures allows to investigate the modulation mechanisms of several proteins including chaperones, like the small HSPs, which display different multimeric structures according to the phosphorylation of a few serine residues.
10p
vioklahoma2711
19-11-2020
11
1
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Overexpression or mutation of the epidermal growth factor receptor (EGFR) potently enhances the growth of many solid tumors. Tumor cells frequently display resistance to mechanistically-distinct EGFR-directed therapeutic agents, making it valuable to develop therapeutics that work by additional mechanisms.
12p
vialabama2711
21-09-2020
12
1
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Design of multivalent ligand is significant in restraining the interaction involved in the binding of influenza virus to its host cell. This molecular dynamics (MD) simulation study aims to study the mode of binding of dimeric NeuNAc analogues coupled by different nano-spacers into the multimeric binding sites of neuraminidase and haemagglutinin of influenza A H5N1 virus. In total, 80 NeuNAc analogue dimers were modeled and docked against the binding sites of neuraminidase and haemagglutinin.
30p
nguaconbaynhay1
04-12-2019
12
2
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In this chapter, you will: Define protein conformation and native conformation, know the difference between a simple and conjugated protein, know what homomeric and heteromeric proteins are, know what monomeric and multimeric proteins are, know the general properties of fibrous and globular proteins, know the 4 levels of protein structure, know the 4 non-covalent forces that are important in determining protein structure,...
27p
tangtuy02
08-03-2016
65
3
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Oligomerization into multimeric complexes is a prerequisite for the chaperone function of almost all a-crystallin type heat shock proteins (a-Hsp), but the molecular details of complex assembly are poorly understood. The a-Hsp proteins from Bradyrhizobium japonicum are suitable bacterial models for structure-function studies of these ubiquitous stress proteins. They fall into two distinct classes, A and B, display chaperone activity in vitro and form oligomers of 24 subunits.
9p
research12
01-06-2013
41
3
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The vacuolar H + -ATPase (V-ATPase) is a multimeric enzyme complex that acidi®es organelles of the vacuolar system in eukaryotic cells. Proteins that interact with the V-ATPase may play an important role in controlling the intracellular localization and activity of the proton pump. The neuroendocrine-enriched V-ATPase accessory subunit Ac45 may represent such a protein as it has been shown to interactwith themembrane sector of theV-ATPase inonlya subset of organelles.
10p
research12
23-04-2013
38
1
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Recombinant, bacterially expressed apoptin protein induces apoptosis inhuman tumour cell lines but not innormal cells, mimicking the behaviour of ectopically expressed apoptin. Recombinant apoptin is isolated exclusively as a highly stablemultimeric complex of 30–40monomers, with little, if any,a-helical and b-sheet structure. Despite its apparent disorder, multimeric apoptin is biologically active. Here, we present evidence thatmost of the apoptinmoietieswithin the complex may well share a similar conformation.
9p
tumor12
20-04-2013
27
2
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Integrase (IN) is the retroviral enzyme responsible for the integration of the DNA copy of the retroviral genome into the host cellDNA. TheC-terminal domainof INis involved in DNA binding and enzyme multimerization. We previ-ously performed single amino acid substitutions in the C-terminal domain of the avian leukemia and sarcoma vir-uses (ALSV) IN [Moreauet al. (2002). Arch. Virol.147, 1761–1778].
13p
fptmusic
12-04-2013
38
3
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The myotonic dystrophy protein kinase polypeptide repertoire in mice and humans consists of six different splice isoforms that vary in the nature of their C-terminal tails and in the presence or absence of an internal Val– Ser–Gly–Gly–Gly motif. Here, we demonstrate that myotonic dystrophy protein kinase isoforms exist in high-molecular-weight complexes controlled by homo- and heteromultimerization.
13p
inspiron33
26-03-2013
36
4
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Coronavirus nucleocapsid protein is abundant in infected cells and partici-pates in viral RNA replication and transcription. The central domain of the nucleocapsid protein contains several arginine⁄serine (RS) dipeptides, the biological significance of which has not been well investigated.
12p
galaxyss3
07-03-2013
43
2
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Protein oligomeric complexes have emerged as a major target of current research because of their key role in aggregation processes in living systems andin vitro. Hydrophobic and charged surfaces may favour the self-assembly process by recruiting proteins and modifying their interactions. We found that equine lysozyme assembles into multimeric complexes with oleic acid (ELOA) at the solid–liquid interface within an ion-exchange chromatography column preconditioned with oleic acid.
15p
vinaphone15
25-02-2013
48
2
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A recent study implicated a role forPlasmodium falciparumarginase in the systemic depletion of arginine levels, which in turn has been associated with human cerebral malaria pathogenesis. Arginase (EC 3.5.3.1) is a multimeric metallo-protein that catalyses the hydrolysis of arginine to ornithine and urea by means of a binuclear spin-coupled Mn 2+ cluster in the active site. A previous report indicated thatP.
14p
viettel02
22-02-2013
32
3
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The milk protein proteose peptone component 3 (PP3), also called lacto-phorin, is a small phosphoglycoprotein that is expressed exclusively in lactating mammary tissue. The C-terminal part of the protein contains an amphipathic helix, which, upon proteolytic liberation, shows antibacterial activity. Previous studies indicate that PP3 forms multimeric structures and inhibits lipolysis in milk.
12p
cosis54
08-12-2012
38
1
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