Protein palmitoylation

Protein palmitoylation, which is critical for membrane association and subcellular targeting of many signaling proteins, is catalyzed mainly by protein S-acyl transferases (PATs). Only a few plant proteins have been experimentally verified to be subject to palmitoylation, such as ROP GTPases, calcineurin B like proteins (CBLs), and subunits of heterotrimeric G proteins.

12p viminato2711 22-05-2020 10 1   Download

Mutations in the human Crumbs homologue 1 (CRB1) gene are a frequent cause of various forms of retinitis pigmentosa. The CRB1–membrane-asso-ciated palmitoylated protein (MPP)5 protein complex is thought to organ-ize an intracellular protein scaffold in the retina that is involved in maintenance of photoreceptor–Mu¨ller glia cell adhesion.

14p inspiron33 26-03-2013 41 3   Download

Proteins are covalently modified with a variety of lipids, including fatty acids, isoprenoids, and cholesterol. Lipid modifications play important roles in the localization and function of proteins. The focus of this review is S-palmitoylation, the reversible addition of palmitate and other long-chain fatty acids to proteins at cysteine residues in a variety of sequence contexts.

9p media19 04-03-2013 27 1   Download