Protein signaling

Modulation of DNA damage repair in lung squamous cell carcinoma (LUSC) can result in the generation of neoantigens and heightened immunogenicity. Therefore, understanding DNA damage repair mechanisms holds significant clinical relevance for identifying targets for immunotherapy and devising therapeutic strategies.

15p vishanshan 27-06-2024 1 1   Download

Hsa_circ_001726 functioned as an oncogene in HCC, which was derived from CCT2 and regulated by E2F6. Hsa_circ_001726 elevated PRMT9 expression by sponging miR-671-5p, and then activated Notch signaling pathway, thereby accelerating malignant phenotypes of HCC. Therefore, targeting hsa_circ_001726 may be a new avenue for HCC treatment.

17p vishanshan 27-06-2024 2 1   Download

Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide. Inhibitor of kappa B kinase interacting protein (IKBIP) has been reported to promote glioma progression, but its role in other cancers remains unclear. This study aimed to investigate the role of IKBIP and its underlying molecular mechanisms in ESCC.

16p vikoch 27-06-2024 1 1   Download

The primary aim of Cerebral Signal Transduction: From First to Fourth Messengers, therefore, is to offer a comprehensive picture of the recent advances made in the signaling field as it relates to neuronal and cere­ bral function. The current state of progress provides an exciting opportunity for such a comprehensive focus because molecular tools have become available to selectively remove, reduce, or enhance spe­ cific components in the signaling pathways, e. g. , by interfering with the genes encoding key proteins.

441p vimeyers 29-05-2024 3 2   Download

Ebook "Proteomics and protein-protein interactions: Biology, chemistry, bioinformatics, and drug design" attempts to bridge the two extreme ends of protein science: on one end, systems proteomics, which describes, at a system level, the intricate connection network that proteins form in a cell, and on the other end, protein chemistry and biophysics, which describe the molecular properties of individual proteins and the structural and thermodynamic basis of their interactions within the network.

325p ladongphongthanh1008 22-04-2024 5 2   Download

Ebook "TNF receptor associated factors (TRAFs)" is the only literature that is entirely devoted to TRAFs. Almost every aspect of TRAF signaling is covered, including the different TRAF family members, their distinct biological functions, the TRAF structures, their modes of receptor recognition, the signaling mechanisms, and the roles of TRAFs in normal cellular functions and in viral infection.

222p ladongphongthanh1008 22-04-2024 1 1   Download

Ebook "Epigenetics in cardiac disease" describes important advances in our understanding of how environmental conditions affect cardiac gene expression through epigenetic mechanisms. Further, it discusses the roles of chromatin modifications (in particular DNA methylation and histone modifications) and of chromatin regulators in the context of cardiac diseases. The book provides readers with an overview of our current understanding of epigenetic regulation in the heart, and will stimulate further research in this exciting field.

321p ladongphongthanh1008 22-04-2024 7 2   Download

Ebook "VEGF in development" is devoted to vascular endothelial growth factor A (VEGF or VEGFA), a secreted signalling protein of great significance for development and disease in vertebrates. VEGFA controls the proliferation, migration, specialisation and survival of vascular endothelial cells, and it is therefore essential for the establishment of a functional blood vessel circuit.

116p tracanhphuonghoa1007 22-04-2024 4 2   Download

Ebook "Cell death signaling in cancer biology and treatment" is to describe state-of-the-art approaches and future opportunities for achieving this goal by targeting mechanisms and pathways that regulate cancer cell death. In this book, molecular defects in cell death signaling that characterize cancer cells, including dysregulation of cell death due to overexpression/hyperactivation of oncoproteins, as well as the loss of tumor suppressor proteins will be described.

412p tracanhphuonghoa1007 22-04-2024 3 1   Download

Ebook "Mitochondria and cell death" examines the role of mitochondria in different types of cell death, including apoptotic and necrotic cell deaths. Topics discussed include mitochondrial outer membrane permeabilization (MOMP) and the permeability transition pore; core processes such as calcium handling, fission and fusion, reactive oxygen species generation, and maintenance of mitochondrial DNA fidelity and protein folding homeostasis; and retrograde signaling between mitochondria and other cellular components, including the important role of mitochondria in antiviral immunity.

242p tracanhphuonghoa1007 22-04-2024 2 2   Download

Ebook "Carbohydrate-based interactions at the molecular and the cellular level" offers a clearly written and highly accessible account of two different aspects of carbohydrate chemistry. Carbohydrates are an essential component of life and have many important biological functions, but the details of how carbohydrates interact with other biomolecules to mediate biological signalling remain unclear. Firstly, this thesis details innovative methods to mine protein structural data to uncover new features of carbohydrate-based interactions.

216p tracanhphuonghoa1007 22-04-2024 4 3   Download

Wnt signaling is an evolutionarily conserved developmental pathway that is frequently hyperactivated in cancer. While multiple protein-coding genes regulated by Wnt signaling are known, the functional lncRNAs regulated by Wnt signaling have not been systematically characterized.

22p vibransone 28-03-2024 2 2   Download

Genome-wide association studies are useful for discovering genotype–phenotype associations but are limited because they require large cohorts to identify a signal, which can be population-specific. Mapping genetic variation to genes improves power and allows the effects of both protein-coding variation as well as variation in expression to be combined into “gene level” effects.

9p vioraclene 31-03-2024 3 2   Download

Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes (T2D). However, the underlying biological mechanisms for many of these associations remain unknown. GWAS signals close to the glucokinase regulatory protein gene (GCKR) have been reported for lipid and glucose metabolism traits and the risk of T2D.

14p vioraclene 31-03-2024 3 2   Download

Tumour necrosis factor (TNF) superfamily cytokines and their receptors regulate diverse immune system functions through a common set of signalling pathways. Genetic variants in and expression of individual TNF superfamily cytokines, receptors and signalling proteins have been associated with autoimmune and inflammatory diseases, but their interconnected biology has been largely unexplored.

15p vioraclene 31-03-2024 2 2   Download

PTEN is a multi-functional tumor suppressor protein regulating cell growth, immune signaling, neuronal function, and genome stability. Experimental characterization can help guide the clinical interpretation of the thousands of germline or somatic PTEN variants observed in patients.

17p vibransone 28-03-2024 1 1   Download

Ebook "Dynamic studies through control of relaxation in NMR spectroscopy" offers a remarkably cogent view of highly sophisticated NMR methods. Salvi developed these methods in order to characterize the amplitudes and frequency ranges of local motions in biomolecules such as proteins. These local motions play an essential role since they can explain many of the remarkable properties of proteins and enable them to carry out all sorts of vital functions, from enzymatic catalysis to intermolecular recognition and signalling in cells.

118p tudohanhtau1006 29-03-2024 4 1   Download

Blood plasma proteins play an important role in immune defense against pathogens, including cytokine signaling, the complement system, and the acute-phase response. Recent large-scale studies have reported genetic (i.e., protein quantitative trait loci, pQTLs) and non-genetic factors, such as age and sex, as major determinants to inter-individual variability in immune response variation.

15p viellison 28-03-2024 3 2   Download

Ebook "Reelin glycoprotein: Structure, biology and roles in health and disease" is a serine protease with important roles in embryogenesis and during adult life. Reelin mutations or deficiency of the protein product could cause abnormal cortical development and reelin signaling impairment in brain. Reelin abnormalities in several neurospychiatric disorders, such as autism, schizophrenia, mood disorders and lissencephaly, may provide mechanistic explanations for etiologies of these disorders.

473p cotieubac1004 15-03-2024 2 0   Download

Ebook "Bone morphogenetic proteins: Systems biology regulators" focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders.

448p cotieubac1004 15-03-2024 3 0   Download