Protein structure prediction

The translation of personal genomics to precision medicine depends on the accurate interpretation of the multitude of genetic variants observed for each individual. However, even when genetic variants are predicted to modify a protein, their functional implications may be unclear.

10p vioraclene 31-03-2024 4 2   Download

Ebook "Protein modelling" detailed description of cutting-edge computational methods applied to protein modeling as well as specific applications are presented. Chapters include: the application of Car-Parrinello techniques to enzyme mechanisms, the outline and application of QM/MM methods, polarizable force fields, recent methods of ligand docking, molecular dynamics related to NMR spectroscopy, computer optimization of absorption, distribution, metabolism and excretion extended by toxicity for drugs, enzyme design and bioinformatics applied to protein structure prediction.

332p tudohanhtau1006 29-03-2024 2 1   Download

Ebook "Computational methods for protein structure prediction and modeling - Volume 1: Basic characterization" is an attempt to fill this gap by providing systematic expositions of the computational methods for all major aspects of protein structure analysis, prediction, and modeling. We have designed the chapters to address comprehensively the main topics of the field. In addition, chapters have been connected seamlessly through a systematic design of the overall structure of the book.

407p cotieubac1004 15-03-2024 1 0   Download

Part 2 book "Applied chemistry and chemical engineering (Vol 2 - Principles, methodology and evaluation methods)" includes content: Protein structure prediction, 3D simulation of electrospun nanofiber jet, fructose and its impact on the diffusion of electrolytes in aqueous systems, application of evolutionary multiobjective optimization in designing chemical engineering and petroleum engineering systems and its wide technological vision - A critical overview and a broad scientific perspective

214p muasambanhan09 16-03-2024 3 1   Download

Ebook Biomolecular simulations in structure-based drug discovery - Part 1 includes content: Predictive power of biomolecular simulations, molecular dynamics–based approaches describing protein binding, markov state models in drug design, understanding the structure and dynamics of peptides and proteins through the lens of network science,… and other contents.

172p longtimenosee03 01-02-2024 1 0   Download

Ebook "Computational methods for GPCR drug discovery" looks at modern computational strategies and techniques used in GPCR drug discovery including structure and ligand-based approaches and cheminformatics.

437p lamquandat 28-12-2023 6 2   Download

Ebook "Mitochondria: Practical protocols (Second edition)" compiles a broad range of step-by-step protocols, complementary to the ones published in the first edition of this book, to study various aspects of mitochondrial structure and function in different model organisms, both in vitro and in vivo. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

410p lucchinguyen 28-12-2023 5 2   Download

Ebook "Modeling peptide-protein interactions: Methods and protocols" covers an array of techniques available for studying peptide-protein docking and design. The book is divided into four sections: peptide binding site prediction; peptide-protein docking; prediction and design of peptide binding specificity; and the design of inhibitory peptides. The chapters in Modeling Peptide-Protein Interactions: Methods and Protocols cover topics such as the usage of ACCLUSTER and PeptiMap for peptide binding site prediction;...

311p lucchinguyen 28-12-2023 6 2   Download

Part 1 book "Advances in veterinary dermatology" includes content: Epidemiology of human atopic dermatitis – seven areas of notable progress and seven areas of notable ignorance, the genomics revolution - will canine atopic dermatitis be predictable and preventable; characterization of canine filaggrin - gene structure and protein expression in dog skin; innate immune defense system of the skin,... and other contents.

151p oursky10 07-12-2023 5 2   Download

The Human Leukocyte Antigen G (HLA-G) protein is an immune tolerogenic molecule with 7 isoforms. The change of expression level and some polymorphisms of the HLA-G gene are involved in various pathologies.

27p vihagrid 30-01-2023 6 3   Download

The ocean microbiome represents one of the largest microbiomes and produces nearly half of the primary energy on the planet through photosynthesis or chemosynthesis. Using recent advances in marine genomics, we explore new applications of oceanic metagenomes for protein structure and function prediction.

14p vielonmusk 30-01-2022 10 0   Download

Single nucleotide variants (SNVs) in intronic regions have yet to be systematically investigated for their diseasecausing potential. Using known pathogenic and neutral intronic SNVs (iSNVs) as training data, we develop the RegSNPs-intron algorithm based on a random forest classifier that integrates RNA splicing, protein structure, and evolutionary conservation features.

16p vielonmusk 30-01-2022 20 0   Download

The diversity of processed transcripts in eukaryotic genomes poses a challenge for the classification of their biological functions. Sparse sequence conservation in non-coding sequences and the unreliable nature of RNA structure predictions further exacerbate this conundrum.

12p vialfrednobel 29-01-2022 5 0   Download

Lecture Bioinformatics I present the content: introduction to bioinformatics, sequence analysis, molecular evolution, RNA secondary structure prediction, protein sequences, protein structures, storage of biological sequence information, similarities & differences in sequences, introduction to alignment approaches, introduction to dynamic programming, dynamic programming methodology, moving from global to local alignment,...

320p bachkhinhdaluu 03-12-2021 14 0   Download

Saintpaulia ionantha H. Wendl (synonym Streptocarpus ionanthus) has been considered an ornamental plant. The PHANTASTICA (PHAN) gene has a significant role in the formation of plant organs adaxial–abaxial polarity. In the present study the PHAN gene was identified in Saintpaulia for the first time using PCR. To determine the expression pattern of the PHAN gene, gene expression was compared at 3 developmental stages using real time PCR.

14p tudichquannguyet 29-11-2021 3 0   Download

Plant oils are very important for domestic and industrial use. Biodiesel can be obtained from plant seed oil. Biodiesel is currently popular and in demand due to the high cost of petroleum and to avoid pollution. It is time to increase plant seed oil production and conduct research to find ways of enhancing its production. We studied two species of oil seed plants, i.e. Ricinus communis and Glycine max, with varying amounts of oil content. Proteins from six categories of enzymes involved in fatty acid biosynthesis were selected for study.

26p tudichquannguyet 29-11-2021 9 1   Download

The molecular features characteristics provided by the 3D-QSAR contour plots were quite useful for designing and improving the activity of acetylcholinesterase of this class. Based on these findings, a new series of 1,2,3-triazole based derivatives were designed, among which compound A1 with the highest predictive activity was subjected to detailed molecular docking and compared to the most active compound.

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Post-translational modification is considered an important biological mechanism with critical impact on the diversification of the proteome. Although a long list of such modifications has been studied, succinylation of lysine residues has recently attracted the interest of the scientific community. The experimental detection of succinylation sites is an expensive process, which consumes a lot of time and resources. Therefore, computational predictors of this covalent modification have emerged as a last resort to tackling lysine succinylation.

10p vilarryellison 29-10-2021 9 0   Download

The location and modular structure of eukaryotic protein-coding genes in genomic sequences can be automatically predicted by gene annotation algorithms. These predictions are often used for comparative studies on gene structure, gene repertoires, and genome evolution.

12p visilicon2711 20-08-2021 8 1   Download

Post-translational modification (PTM), which is a biological process, tends to modify proteome that leads to changes in normal cell biology and pathogenesis. In the recent times, there has been many reported PTMs. Out of the many modifications, phosphoglycerylation has become particularly the subject of interest.

9p visilicon2711 20-08-2021 11 1   Download