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Proteinase 3
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To improve the prognosis of patients with metastatic colorectal cancer (mCRC), investigating predictive biomarkers of their prognosis and chemotherapeutic responsiveness is necessary. This study aimed to analyze the clinical significance of serum proteinase-3 (PRTN3) as a predictor for prognosis and chemosensitivity, especially to bevacizumab therapy, in mCRC.
15p
vikoch
27-06-2024
1
1
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Anti-glomerular basement membrane (anti-GBM) disease and antineutrophil cytoplasm antibody (ANCA)-associated vasculitis are the main causes of pulmonary-renal syndrome (PRS). The concurrence of both ANCA - myeloperoxidase (MPO) and proteinase 3 (PR3) - and anti-GBM antibodies has been described, although positivity for all three antibodies has rarely been reported. The natural history of triplepositive patients as well as the best therapeutic approach remains unknown.
6p
viintuit
26-09-2023
2
0
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This report describes a hitherto unique case of eosinophilic granulomatosis with polyangiitis (EGPA), a subtype of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. The patient was an 81-year-old man whose clinical course involved notable changes in the ANCA profile, specifically a transition from positive proteinase 3 (PR3)-ANCA to myeloperoxidase (MPO)-ANCA, followed by simultaneous positivity for both.
8p
viintuit
26-09-2023
3
0
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For the first time a molecularly imprinted polymer (MIP)-based sensor for tyrosinase is described. This sensor is based on the electropolymerization of scopoletin or o-phenylenediamine in the presence of tyrosinase from mushrooms, which has a high homology to the human enzyme. The template was removed either by treatment with proteinase K or by alkaline treatment. The measuring signal was generated either by measuring the formation of a product by the target enzyme or by evaluation of the permeability of the redox marker ferricyanide.
9p
tudichquannguyet
29-11-2021
11
2
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The clinical characteristics of myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) positive granulomatosis with polyangiitis (GPA) remain unclear, as does the difference between MPO-ANCA positive GPA and proteinase 3 (PR3)-ANCA positive GPA, especially with regard to the details of respiratory tract involvement.
11p
vimontana2711
05-04-2021
9
2
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Salivaricin B (SalB) is a protein encoded by Lactobacillus salivarius M7. This protein is insensitive to proteolytic enzymes, such as pepsin, trypsin, and chymotrypsin, but is partially sensitive to proteinase K. SalB is also stable and maintains its activity over a range of pHs, from 3 to 9.
6p
vitamix
15-02-2019
16
1
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Elafin and its precursor, trappin-2 or pre-elafin, are specific endogenous inhibitors of human neutrophil elastase and proteinase 3 but not of cathepsin G. Both inhibitors belong, together with secretory leukocyte protease inhibitor, to the chelonianin family of canonical protease inhibitors of serine proteases. AcDNAcoding either elafin or its precursor, trappin-2, was fused in framewith yeasta-factor cDNAand expressedinthePichiapastorisyeast expressionsystem.
9p
dell39
03-04-2013
38
3
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Neutrophil proteinase-mediated lung tissue destruction is prevented by inhibitors, including elafin and its precursor, trappin. We wanted to estab-lish whether neutrophil-derived oxidants might impair the inhibitory func-tion of these molecules. Myeloperoxidase⁄H2O2 and N-chlorosuccinimide oxidation of the inhibitors was checked by mass spectrometry and enzy-matic methods.
11p
dell39
27-03-2013
42
3
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The proprotein convertase PC1⁄3 preferentially cleaves its substrates in the dense core secretory granules of endocrine and neuroendocrine cells. Sim-ilar to most proteinases synthesized first as zymogens, PC1⁄3 is synthesized as a larger precursor that undergoes proteolytic processing of its signal peptide and propeptide.
10p
galaxyss3
19-03-2013
31
2
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Proteinase 3 and neutrophil elastase are serine proteinases of the polymor-phonuclear neutrophils, which are considered to have both similar localiza-tion and ligand specificity because of their high sequence similarity. However, recent studies indicate that they might have different and yet complementary physiologic roles.
17p
mobifone23
21-01-2013
37
3
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ADAMTS (A Disintegrin and Metalloproteinase with Thrombo-spondin Motifs) are zinc dependent proteases have a part in impor-tant physiologic processes such as development, homeostasis and fertility. To date, 19 different ADAMTS proteases have been iden-tified. ADAMTS-2 is a member of ADAMTS family. Together with ADAMTS-3 and ADAMTS-14, ADAMTS-2 has procollagen N-proteinase activity.
372p
cosis54
05-01-2013
53
4
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In routine histopathology, most tissues are fixed in formalin and embedded in paraffin for long-term preservation. DNA can be extracted from these tissues for subsequent molecular analysis by amplification methods. We describe herein a protocol for DNA preparation from paraffin-embedded tissues based on published procedures (1–3). In brief, tissue sections are placed into microfuge tubes, then deparaffinized with xylene. The xylene is removed with ethanol washes, and the tissue is treated with proteinase K to make DNA available for amplification....
456p
maket1311
16-10-2012
45
7
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Abstract Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are capable of cleaving all extra cellular matrix (ECM) substrates. Degradation of matrix is a key event in progression, invasion and metastasis of potentially malignant and malignant lesions of the head and neck. It might have an important polymorphic association at the promoter regions of several MMPs such as MMP-1 (-1607 1G/2G), MMP-2 (-1306 C/T), MMP-3 (-1171 5A/6A), MMP-9 (-1562 C/T) and TIMP-2 (-418 G/C or C/C)....
13p
toshiba23
18-11-2011
67
3
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Proteinase-3 as the major autoantigen of c-ANCA is strongly expressed in lung tissue of patients with Wegener’s granulomatosis...
7p
thulanh12
12-10-2011
40
2
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Bromelain thân (EC 3.4.22.33) là một trong các enzyme cystein proteinase được tìm thấy nhiều nhất trong dứa (Ananas comosus (L.) Merr.). Dứa là trái cây của miền nhiệt đời, có nguồn gốc từ các quốc gia Brazil, Paraguay ở Trung và Nam Mỹ.Khi Christopher Columbus (1451-1506) thám hiểm Mỹ châu, thấy dứa trồng ở quần đảo Guadeloup rất ngon, bèn mang về triều cống nữ hoàng Tây Ban Nha Isabella Đệ nhất. Từ đó, dứa được đem trồng ở các thuộc địa của Tây Ban Nha, nhất là các quốc gia thuộc khu vực Thái Bình Dương như Phi Luật Tân....
9p
may2705
28-07-2010
367
152
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