Proteomic profiling

Among gynaecological malignancies, endometrial cancer (EC) is the most prevalent type of uterine cancer affecting women. This study explored the proteomic profiles of plasma samples obtained from EC patients, those with hyperplasia (Hy), and a control group (CO).

17p vikoch 27-06-2024 1 1   Download

Transcriptome analysis of breast cancer discovered distinct disease subtypes of clinical significance. However, it remains a challenge to define disease biology solely based on gene expression because tumor biology is often the result of protein function. Here, we measured global proteome and transcriptome expression in human breast tumors and adjacent non-cancerous tissue and performed an integrated proteotranscriptomic analysis.

14p vibransone 28-03-2024 2 2   Download

Comprehensive molecular profiling has revealed somatic variations in cancer at genomic, epigenomic, transcriptomic, and proteomic levels. The accumulating data has shown clearly that molecular phenotypes of cancer are complex and influenced by a multitude of factors.

13p vibransone 28-03-2024 6 1   Download

Ebook "Root genomics" examines how various new genomic technologies are rapidly being applied to the study of roots, including high-throughput sequencing and genotyping, TILLING, transcription factor analysis, comparative genomics, gene discovery and transcriptional profiling, post-transcriptional events regulating microRNAs, proteome profiling and the use of molecular markers such as SSRs, DArTs, and SNPs for QTL analyses and the identification of superior genes/alleles.

328p tachieuhoa 28-01-2024 5 2   Download

Ebook "Activity-based proteomics: Methods and protocols" focuses on explorative activity-based proteomics, biomedical applications of activity-based proteomics, and chemical strategies in activity-based proteomics providing a concise overview of activity-based protein profiling. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

222p lucchinguyen 28-12-2023 18 2   Download

Ebook "Difference gel electrophoresis: Methods and protocols" provides a comprehensive update of this key method on gel-based proteomics. Chapters present an introduction into the development of methods on principles of differential protein labeling and two-dimensional gel electrophoresis, techniques on optimized proteomic workflows using advanced mass spectrometry for protein identification, and the application of those methods in basic biological research, pathobiology and applied biomarker discovery.

310p lucchinguyen 28-12-2023 6 2   Download

Ebook "Genome instability: Methods and protocols" presents forty-two methods and protocols to analyze diverse aspects of genome instability. Chapters detail mutagenesis and repair, methods to quantify and analyze the properties of DNA double-strand breaks, profile replication, replication proteins strand-specifically, genome instability, fluorescence microscopic techniques, and genomic and proteomic approaches.

654p lucchinguyen 28-12-2023 6 2   Download

Part 2 book "Farm animal proteomics" includes content: Proteome analysis of muscles longissimus dorsi of Hungarian Merino and Tsigai sheep breeds; muscle proteomics profiles in sheep - the effect of breed and nutritional status, cellular and molecular-large scale features of fetal perirenal and intermuscular adipose tissues in bovine, vegetable based fish feed changes protein expression in muscle of rainbow trout (The proteomic insight of the Italian dry cured ham manufacturing,... and other contents.

86p muasambanhan02 18-12-2023 1 0   Download

Part 2 book "Farm animal proteomics 2013" includes content: Biomarkers of winter disease in gilthead seabream - a proteomics approach, the absorption of colostral proteins in newborn lambs - an iTRAQ proteomics study, plasma proteome profiles predict diet-induced metabolic syndrome and the early onset of metabolic syndrome in a pig model, changes in protein abundance in the vertebral columnof, atlantic salmon (Salmosalar) fed variable dietary P levels,... and other contents.

129p muasambanhan02 18-12-2023 1 0   Download

Cancer patients have an increased risk of developing venous thromboembolism, with up to 30% dying within a month of their development. Some cancer cells are known to induce platelet aggregation, and this interaction is understood to contribute to thrombosis and haematogenous metastasis.

12p vialfrednobel 23-12-2023 7 4   Download

Part 1 book "Biomarkers in medicine, drug discovery, and environmental health" includes content: Biomarkers - An evolutionary perspective; genomics; proteomics for biomarker discovery; metabolic profiling for biomarker discovery; the bittersweet promise of glycobiology, biomarkers of alzheimer's and parkinson's disease; biomarkers of cardiac injury; lung injury biomarkers; translational biomarkers of acute drug induced liver injury - the current state, gaps, and future opportunities; biomarkers of acute kidney injury; in search of biomarkers for drug induced vascular injury.

336p oursky09 12-11-2023 5 3   Download

Part 1 book "Biomarkers - In medicine, drug discovery, and environmental health" includes content: Biomarkers - An evolutionary perspective; genomics; proteomics for biomarker discovery; metabolic profiling for biomarker discovery, the bittersweet promise of glycobiology; biomarkers of Alzheimer's and Parkinson's disease; biomarkers of cardiac injury; lung injury biomarkers; translational biomarkers of acute drug induced liver injury - the current state, gaps, and future opportunities; biomarkers of acute kidney injury; in search of biomarkers for drug induced vascular injury.

336p oursky07 23-10-2023 3 1   Download

Prostate cancer is a disease that seriously troubles men. However, there are some inevitable limitations in interventional therapy for prostate cancer patients at present, most of which are caused by low selectivity and high toxic side effects due to unclear drug targets. In this study, we identified the target protein of Curcusone C with antiprostate cancer potential activity and verified its target and mechanism of action.

14p visharma 20-10-2023 5 2   Download

Lymph node (LN) metastasis is the earliest sign of metastatic spread and an established predictor of poor outcome in gallbladder cancer (GBC). Patients with LN positive GBC have a significantly worse survival (median survival- 7 months) than patients with LN negative disease (median survival-~23 months) in spite of standard treatment which includes extended surgery followed by chemotherapy, radiotherapy and targeted therapy.

15p visharma 20-10-2023 4 2   Download

Propofol is a safe and effective intravenous anesthetic that is widely used for the induction and maintenance of anesthesia during surgery. However, the mechanism by which propofol exerts its anesthetic effect remains unknown. The rapid onset of phosphorylation modifications coincides with that of propofol anesthesia.

10p viisaacnewton 26-04-2022 7 1   Download

Cryptorchidism is a condition that occurs when one or both testes fail to descend into the scrotum. It is a common congenital disorder, causing economic loss in pig production. However, there have been only limited studies of differential protein expression profiles in undescended testes (UDTs) in the abdomen and descended testes (DTs) in cryptorchid pigs, especially at the peptidome and proteome levels.

9p vigandhi 23-02-2022 14 1   Download

Various types of oral tumors, either benign or malignant, are commonly found in dogs. Since saliva directly contacts the tumors and saliva collection is non-invasive, easily accessible and cost effective, salivary biomarkers are practical to be used for the diagnosis and/or prognosis of these diseases.

17p vigandhi 23-02-2022 15 1   Download

Dogs’ saliva is a complex mixture of inorganic and organic constituents, rich in proteins. Therefore, knowing the saliva composition of these animals is extremely important to identify the presence of proteins that may be involved in physiological and pathological mechanisms of their oral cavity.

12p vigandhi 23-02-2022 9 1   Download

Alu elements are major contributors to lineage-specific new exons in primate and human genomes. Recent studies indicate that some Alu exons have high transcript inclusion levels or tissue-specific splicing profiles, and may play important regulatory roles in modulating mRNA degradation or translational efficiency. However, the contribution of Alu exons to the human proteome remains unclear and controversial.

14p viaristotle 29-01-2022 10 0   Download

We present a scalable, integrated strategy for coupled protein and RNA detection from single cells. Our approach leverages the DNA polymerase activity of reverse transcriptase to simultaneously perform proximity extension assays and complementary DNA synthesis in the same reaction.

15p viaristotle 29-01-2022 6 0   Download