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pyrimido [1
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A facile one-pot synthesis of novel oxindole derivatives bearing benzothiazolylmethyl-2-thioxothiazolidin-4- one was accomplished via one-pot reaction of 5-oxoindolinylidene rhodanine-3-acetic acid derivatives, 2-aminothiophenol, and triphenyl phosphite in the presence of tetrabutylammonium bromide (TBAB) and nano silica-bonded 5-n-propyloctahydro-pyrimido[1,2-a]azepinium chloride (NSB-DBU) as heterogeneous reusable nanocatalyst. The target compounds were obtained in excellent yields (85%–92%) and short reaction times under fairly mild reaction conditions.
9p
langthannam
29-12-2021
13
1
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A simple and efficient one-pot synthesis of novel thieno[3’,2’:5,6]pyrimido[1,2-a]quinoline-2-carboxylates (5a– d) and their spirooxindole derivatives (12a–d) was accomplished. Thus, the Michael addition reaction of the cyclic β-enaminone 3 with the corresponding α, β-unsaturated nitrile derivatives 4a–d in refluxing EtOH in the presence of piperidine afforded 5a–d in good yields. On the other hand, spirooxindole derivatives 12a–d were synthesized by the reaction of cyclic β-enaminone 3 with the corresponding 3-cyanomethylidene-2-oxoindoles 11a–d in refluxing EtOH.
7p
langthannam
29-12-2021
16
0
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A one-pot, environmentally friendly, and efficient protocol for the synthesis of novel polyfunctionalized benzo[a]pyrimido[5’,4’:5,6]pyrido[2,3-c ]phenazine derivatives has been reported by a one-pot, four-component sequential reaction between 2-hydroxynaphthalene-1,4-dione, benzene-1,2-diamines, benzaldehydes, and 6-amino-1,3-dimethyluracil in the presence of p-TSA as a nontoxic, inexpensive, ecofriendly, and efficacious solid acid catalyst. Two C-C bonds, two C=N bonds, and one C-N bond, as well as two new rings, were formed in this reaction.
10p
tudichquannguyet
29-11-2021
19
1
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A series of novel 10-phenylsulfonyl-2-substituted-4,10 dihydrobenzo[4,5]imidazo[1,2- a]pyrimidin-4-one derivatives obtained from N-sulfonation of 2-substituted-pyrimido[1,2- a]benzimidazol-4(10H)-ones and screened for for their in vitro anti-tuberculosis activities against Mycobacterium tuberculosis H37Rv by Microplate Alamar Blue Assay (MABA) method.
8p
tocectocec
25-05-2020
13
1
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The selectivity index of these compounds is similar to that of cidofovir. Although antiviral activity was evident in secondary assays, significant virus inhibition occurred at or near the cytotoxic concentration (SI90=1).
8p
tocectocec
25-05-2020
9
0
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The reaction of 6-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione (1) as a binucleophile with primary aromatic or heterocyclic amines and formaldehyde or aromatic (heterocyclic) aldehydes in a molar ratio (1:1:2) gave the pyrimido[4,5-d]pyrimidin-2,4-dione ring systems 2–5. Treatment of 1 with diamines and formalin in molar ratio (2:1:4) gave the bis-pyrimido[4,5-d]pyrimidin-2,4-diones 6–8. Furthermore, substituted pyrimido[4,5-d]pyrimidin-2,4-diones with uracil derivative 11 or spiro indole 16 were synthesized.
7p
kethamoi1
17-11-2019
16
1
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