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Quantitative genomic
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Part 1 book "Plant epigenetics and epigenomics - Methods and protocols" includes content: Landscaping plant epigenetics, the gene balance hypothesis - dosage effects in plants; inference of allele specific expression from RNA seq data 5 screening for imprinted genes using high resolution melting analysis of PCR amplicons; analysis of genomic imprinting by quantitative allele specific expression by pyrosequencing,... and other contents.
20p
dianmotminh04
12-07-2024
0
0
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Part 1 book "Quantitative genetics, genomics and plant breeding" includes content: Quantitative genetics, genomics and the future of plant breeding; why quantitative geneticists should care about bioinformatics; QTL analysis - problems and (possible) solutions; association mapping in plant populations; integrating molecular techniques into quantitative genetics and plant breeding; use of molecular markers in plant breeding - drought tolerance improvement in tropical maize, explorations with barley genome maps;... and other contents.
235p
dianmotminh04
12-07-2024
1
0
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Part 2 book "Quantitative genetics, genomics and plant breeding" includes content: Genotype–environment interaction - Progress and prospects; analysing QTL–environment interaction by factorial regression, with an application to the cimmy drought and low nitrogen STR; elements of genotype–environment interaction - genetic components of the photoperiod response in maize; mechanisms of improved nitrogen use efficiency in cereals; biplot analysis of multi environment trial data,... and other contents.
182p
dianmotminh04
12-07-2024
0
0
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The etiology of ASD involves both inherited and environmental risk factors, with epigenetic processes hypothesized as one mechanism by which both genetic and non-genetic variation influence gene regulation and pathogenesis. The aim of this study was to identify DNA methylation biomarkers of ASD detectable at birth.
13p
vibransone
28-03-2024
3
2
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Only a small fraction of patients respond to the drug prescribed to treat their disease, which means that most are at risk of unnecessary exposure to side effects through ineffective drugs. This inter-individual variation in drug response is driven by differences in gene interactions caused by each patient’s genetic background, environmental exposures, and the proportions of specific cell types involved in disease.
15p
vibransone
28-03-2024
4
2
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International guidelines for variant interpretation in Mendelian disease set stringent criteria to report a variant as (likely) pathogenic, prioritising control of false-positive rate over test sensitivity and diagnostic yield.
18p
vibransone
28-03-2024
2
2
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Next-generation sequencing has allowed for the identification of different genetic variations, which are known to contribute to diseases. Of these, insertions and deletions are the second most abundant type of variations in the genome, but their biological importance or disease association is not well-studied, especially for deletions of intermediate sizes.
15p
vibransone
28-03-2024
3
2
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Expression quantitative trait loci (eQTL) analysis is a powerful method to detect correlations between gene expression and genomic variants and is widely used to interpret the biological mechanism underlying identified genome wide association studies (GWAS) risk loci.
15p
vioraclene
31-03-2024
4
2
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Biological interpretation of genomic summary data such as those resulting from genome-wide association studies (GWAS) and expression quantitative trait loci (eQTL) studies is one of the major bottlenecks in medical genomics research, calling for efficient and integrative tools to resolve this problem.
20p
vioraclene
31-03-2024
7
1
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Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated with complex traits and diseases. However, elucidating the causal genes underlying GWAS hits remains challenging.
6p
vioraclene
31-03-2024
4
2
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Expression quantitative trait loci (eQTL) databases represent a valuable resource to link diseaseassociated SNPs to specific candidate genes whose gene expression is significantly modulated by the SNP under investigation.
16p
vioraclene
31-03-2024
4
2
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The Generation Scotland: Scottish Family Health Study (GS:SFHS) is a family-based population cohort with DNA, biological samples, socio-demographic, psychological and clinical data from approximately 24,000 adult volunteers across Scotland.
14p
vioraclene
31-03-2024
5
2
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Clinical laboratory (lab) tests are used in clinical practice to diagnose, treat, and monitor disease conditions. Test results are stored in electronic health records (EHRs), and a growing number of EHRs are linked to patient DNA, offering unprecedented opportunities to query relationships between genetic risk for complex disease and quantitative physiological measurements collected on large populations.
16p
vibransone
28-03-2024
4
2
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Accurately quantifying the risk of osteoporotic fracture is important for directing appropriate clinical interventions. While skeletal measures such as heel quantitative speed of sound (SOS) and dual-energy X-ray absorptiometry bone mineral density are able to predict the risk of osteoporotic fracture, the utility of such measurements is subject to the availability of equipment and human resources.
15p
vibransone
28-03-2024
4
2
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Amyotrophic lateral sclerosis (ALS) is a complex, late-onset, neurodegenerative disease with a genetic contribution to disease liability. Genome-wide association studies (GWAS) have identified ten risk loci to date, including the TNIP1/GPX3 locus on chromosome five.
22p
vibransone
28-03-2024
3
1
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Genome-wide association studies (GWASs) have identified multiple risk loci for bipolar disorder (BD). However, pinpointing functional (or causal) variants in the reported risk loci and elucidating their regulatory mechanisms remain challenging.
20p
viellison
28-03-2024
3
2
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Blood plasma proteins play an important role in immune defense against pathogens, including cytokine signaling, the complement system, and the acute-phase response. Recent large-scale studies have reported genetic (i.e., protein quantitative trait loci, pQTLs) and non-genetic factors, such as age and sex, as major determinants to inter-individual variability in immune response variation.
15p
viellison
28-03-2024
3
2
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The genetic underpinning of sexual dimorphism is very poorly understood. The prevalence of many diseases differs between men and women, which could be in part caused by sex-specific genetic efects. Nevertheless, only a few published genome-wide association studies (GWAS) were performed separately in each sex.
13p
viellison
28-03-2024
2
2
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Ebook "Tetramer stability and functional regulation of tumor suppressor protein p53" presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays a central role in maintaining genomic integrity. Inactivation of p53 via mutation of its gene is a key step in tumorigenesis.
82p
coduathanh1122
27-03-2024
1
1
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Ebook "Prokaryotic systems biology (Advances in experimental medicine and biology, Volume 883)" focuses on innovative experimental and computational approaches for charting interaction networks in bacterial species.
326p
duongthandue0501
28-02-2024
3
1
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