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Quantitative proteomic
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Primary prostate cancer with metastasis has a poor prognosis, so assessing its risk of metastasis is essential. Methods This study combined comprehensive ultrasound features with tissue proteomic analysis to obtain biomarkers and practical diagnostic image features that signify prostate cancer metastasis.
13p
vikoch
27-06-2024
2
1
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The proteome is a major source of therapeutic targets. We conducted a proteome-wide Mendelian randomization (MR) study to identify candidate protein markers and therapeutic targets for colorectal cancer (CRC).
13p
vicwell
29-02-2024
2
1
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Human proteins are widely used as drug targets. Integration of large-scale protein-level genome-wide association studies (GWAS) and disease-related GWAS has thus connected genetic variation to disease mechanisms via protein. Previous proteome-by-phenome-wide Mendelian randomization (MR) studies have been mainly focused on plasma proteomes.
22p
vicwell
29-02-2024
3
1
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Ebook "Advancements of mass spectrometry in biomedical research" explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease, and psychiatry. Additional chapters focus on methodology, technologies and instrumentation, as well as on analysis of protein-protein interactions, protein quantitation, and protein post-translational modifications. Various omics fields such as proteomics, metabolomics, glycomics, lipidomics, and adductomics are also covered.
601p
nhanphanguyet
28-01-2024
2
2
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Ebook "Applications of monolithic column and isotope dimethylation labeling in shotgun proteome analysis" discusses the preparation of new monolithic columns and optimization of chromatography separation capability to improve coverage and accuracy of proteome analysis. Further, the author describes a novel online multidimensional chromatography system combined with automated online isotope labeling, which significantly improves the throughput, sensitivity and accuracy of quantitative proteomics.
103p
nhanphanguyet
28-01-2024
4
2
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Ebook "Peptidomics: Methods and strategies" describes protocols for basic state-of-the-art approaches in the field of peptidomics. Most of these approaches are independent of the instruments used for analysis and can easily be adapted for equipment that is available in a typical proteomics facility. Chapters detail many of the basic techniques used to detect and identify peptides, methods for the relative quantitation of peptides between samples using isotopic labels or label-free approaches, and biological species as well as sample types.
423p
lucchinguyen
28-12-2023
7
2
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Part 1 book "Farm animal proteomics 2013" includes content: Mining deeper into the proteome - pros and cons of pre-fractionation and depletion; detection and annotation of common posttranslational modifications in mass spectrometry data, applied bioinformatics in the structural, postgenomic era, PTMomics – a potpourri of experimental approaches; gel-free quantitative proteomics approaches, current status; new proteomics strategies applied to clinical studies,... and other contents.
168p
muasambanhan02
18-12-2023
0
0
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Preoperative neoadjuvant chemoradiation (nCRT) has been the standard treatment for locally advanced rectal cancer. Serum biomarkers to stratify patients with respect to prognosis and response to nCRT are needed due to the diverse response to the therapy.
13p
vialfrednobel
23-12-2023
5
3
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Part 1 book "Salmonella - Methods and protocols" includes content: Luminex® multiplex bead suspension arrays for the detection and serotyping of salmonella spp.; quantitative proteomic identification of host factors involved in the salmonella typhimurium infection cycle; determination of antimicrobial resistance in salmonella spp.; red mediated recombineering of salmonella enterica genomes; a method to introduce an internal tag sequence into a salmonella chromosomal gene,... and other contents.
129p
muasambanhan01
13-12-2023
9
4
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The global emergence of low water availability causes extensive damage to crops in many regions. Although the responses of plants to drought stress have been extensively investigated, molecular studies on plants with different carboxylation pathways are limited. Therefore, we aimed to identify quantitative differences in proteins functioning in differential drought tolerance of C3 (Cleome spinosa) and C4 (C. gynandra) species.
12p
lyhuyenthu
31-01-2023
3
2
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Bud mutation is a vital method of citrus. ‘Wuzi Ougan’ (mutant type, MT) as a bud variant of ‘Ougan’ (wild type, WT) was first found in 1996 and has become popular because of its male sterility and seedless character.
17p
vihagrid
30-01-2023
9
3
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Gonadotropin-releasing hormone (GnRH) receptor, a rhodopsin-like G-protein coupled receptor (GPCR) family member involved in GnRH signalling, is reported to be expressed in several tumors including glioblastoma multiforme (GBM), one of the most malignant and aggressive forms of primary brain tumors.
12p
vipriyankagandhi
27-07-2022
3
2
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With evidence of warming climates, it is important to understand the effects of heat stress in farm animals in order to minimize production losses. Studying the changes in the brain proteome induced by heat stress may aid in understanding how heat stress affects brain function.
11p
vigandhi
23-02-2022
7
1
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Proteases represent one of the most abundant classes of enzymes in eukaryotes and are known to play key roles in many biological processes in plants. However, little is known about their functions in fruit ripening and disease resistance, which are unique to flowering plants and required for seed maturation and dispersal.
23p
vialfrednobel
29-01-2022
11
0
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High-throughput technologies have revolutionized medical research. The advent of genotyping arrays enabled large-scale genome-wide association studies and methods for examining global transcript levels, which gave rise to the field of “integrative genetics”. Other omics technologies, such as proteomics and
15p
vialfrednobel
29-01-2022
9
0
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Protein complexes are dynamic. A new analysis of two quantitative proteomic datasets reveals cell type-specific changes in the stoichiometry of complexes, which often involve paralog switching.
3p
viaristotle
29-01-2022
9
0
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As in animals, cell–cell communication plays a pivotal role in male–female recognition during plant sexual reproduction. Prelaid peptides secreted from the female reproductive tissues guide pollen tubes towards ovules for fertilization. However, the elaborate mechanisms for this dialogue have remained elusive, particularly from the male perspective.
29p
viaristotle
29-01-2022
10
0
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Macrophages are innate immune cells with diverse functional and molecular phenotypes. This diversity is largely unexplored at the level of single-cell proteomes because of the limitations of quantitative single-cell protein analysis.
27p
viarchimedes
26-01-2022
7
0
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Genomic data from various organisms have been used to study how sexual selection has shaped genetic diversity in reproductive proteins, and in particular, to elucidate how mating systems may have influenced evolution at the molecular and phenotypic levels. However, large-scale proteomic data including protein identifications and abundances are only now entering the field of evolutionary and comparative genomics. Variation in both protein sequence and expression level may play important roles in the evolution of sexual traits and behaviors.
17p
vibeauty
23-10-2021
12
1
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Spike architecture mutants in tetraploid wheat (Triticum turgidum L., 2n = 28, AABB) have a distinct morphology, with parts of the rachis node producing lateral meristems that develop into ramified spikelete (RSs) or four-rowed spikelete (FRSs). The genetic basis of RSs and FRSs has been analyzed, but little is known about the underlying developmental mechanisms of the lateral meristem.
14p
vibeauty
23-10-2021
4
1
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