Quantitative trait variation
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The etiology of ASD involves both inherited and environmental risk factors, with epigenetic processes hypothesized as one mechanism by which both genetic and non-genetic variation influence gene regulation and pathogenesis. The aim of this study was to identify DNA methylation biomarkers of ASD detectable at birth.
13p vibransone 28-03-2024 3 2 Download
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Only a small fraction of patients respond to the drug prescribed to treat their disease, which means that most are at risk of unnecessary exposure to side effects through ineffective drugs. This inter-individual variation in drug response is driven by differences in gene interactions caused by each patient’s genetic background, environmental exposures, and the proportions of specific cell types involved in disease.
15p vibransone 28-03-2024 4 2 Download
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Next-generation sequencing has allowed for the identification of different genetic variations, which are known to contribute to diseases. Of these, insertions and deletions are the second most abundant type of variations in the genome, but their biological importance or disease association is not well-studied, especially for deletions of intermediate sizes.
15p vibransone 28-03-2024 3 2 Download
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Blood plasma proteins play an important role in immune defense against pathogens, including cytokine signaling, the complement system, and the acute-phase response. Recent large-scale studies have reported genetic (i.e., protein quantitative trait loci, pQTLs) and non-genetic factors, such as age and sex, as major determinants to inter-individual variability in immune response variation.
15p viellison 28-03-2024 3 2 Download
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Human proteins are widely used as drug targets. Integration of large-scale protein-level genome-wide association studies (GWAS) and disease-related GWAS has thus connected genetic variation to disease mechanisms via protein. Previous proteome-by-phenome-wide Mendelian randomization (MR) studies have been mainly focused on plasma proteomes.
22p vicwell 29-02-2024 3 1 Download
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Part 2 book "Bovine genomics" includes contents: Bovine genome architecture, bovine epigenetics and epigenomics, mapping quantitative trait loci, genome wide association studies and linkage disequilibrium in cattle, genomic selection in beef cattle, impact of high throughput genotyping and sequencing on the identification of genes and variants underlying phenotypic variation in domestic cattle.
149p oursky04 14-09-2023 9 3 Download
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Spotted wilt, caused by tomato spotted wilt virus (TSWV), has been one of major diseases in cultivated peanut grown in the southeastern United States (US) since 1990. Previously a major quantitative trait locus (QTL) controlling spotted wilt disease resistance was mapped to an interval of 2.55 cM genetic distance corresponding to a physical distance of 14.4 Mb on chromosome A01 of peanut by using a segregating F2 population.
12p vinarcissa 21-03-2023 1 1 Download
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One of the major impediments to spiny lobster aquaculture is the high cost of hatchery production due to the long and complex larval cycle and poor survival during the many moult stages, especially at metamorphosis. We examined if the key trait of larval survival can be improved through selection by determining if genetic variance exists for this trait.
9p vinarcissa 21-03-2023 4 1 Download
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Quantitative traits are common in nature, but quantitative pathogenicity has received only little attention in phytopathology. In this study, we used 100 Fusarium culmorum isolates collected from natural field environments to assess their variation for two quantitative traits, aggressiveness and deoxynivalenol (DON) production on wheat plants grown in four different field environments (location-year combinations).
12p vinarcissa 21-03-2023 2 1 Download
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High-resolution mapping of the loci (QTN) responsible for genetic variation in quantitative traits is essential for positional cloning of candidate genes, and for effective marker assisted selection. The confidence interval (QTL) flanking the point estimate of QTN-location is proportional to the number of individuals in the mapping population carrying chromosomes recombinant in the given interval.
16p vinarcissa 21-03-2023 2 1 Download
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Tuber appearance is highly variable in the Andean cultivated potato germplasm. The diploid backcross mapping population ‘DMDD’ derived from the recently sequenced genome ‘DM’ represents a sample of the allelic variation for tuber shape and eye depth present in the Andean landraces. Here we evaluate the utility of morphological descriptors for tuber shape for identification of genetic loci responsible for the shape and eye depth variation.
10p vinarcissa 21-03-2023 3 1 Download
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Root is the prime organ that sucks water and nutrients from deep layer of soil. Wild barley diversity exhibits remarkable variation in root system architecture that seems crucial in its adaptation to abiotic stresses like drought. In the present study, we performed quantitative trait locus (QTL) mapping of root and related shoot traits under control and drought conditions using a population of wild barley introgression lines (ILs).
12p vinarcissa 21-03-2023 4 1 Download
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To optimize marker-assisted selection programs, knowledge of the genetic architecture of phenotypic traits is very important for breeders. Generally, most phenotypes, e.g. morphological and physiological traits, are quantitatively inherited, and thus detection of the genes underlying variation for these traits is difficult.
8p vinarcissa 21-03-2023 5 1 Download
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In genetic analysis of agronomic traits, quantitative trait loci (QTLs) that control the same phenotype are often closely linked. Furthermore, many QTLs are localized in specific genomic regions (QTL clusters) that include naturally occurring allelic variations in different genes
17p vinarcissa 21-03-2023 3 1 Download
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Inducing mutations are considered to be an effective way to create novel genetic variations and hence novel agronomical traits in wheat. This study was conducted to assess the genetic differences between Shi4185 and its mutant line Fu4185, produced by gamma radiation with larger grain, and to identify quantitative trait loci (QTLs) for thousand kernel weight (TKW).
9p vinarcissa 21-03-2023 4 1 Download
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Quantitative traits are typically considered to be under additive genetic control. Although there are indications that non-additive factors have the potential to contribute to trait variation, experimental demonstration remains scarce. Here, we investigated the genetic basis of growth in Atlantic salmon by exploiting the high level of genetic diversity and trait expression among domesticated, hybrid and wild populations.
17p vihagrid 30-01-2023 5 3 Download
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Gene expression is potentially an important heritable quantitative trait that mediates between genetic variation and higher-level complex phenotypes through time and condition-dependent regulatory interactions.
13p vihagrid 30-01-2023 5 3 Download
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Most congenital heart defects (CHDs) result from complex interactions among genetic susceptibilities, epigenetic modifications, and maternal environmental exposures. Characterizing the complex relationship between genetic, epigenetic, and transcriptomic variation will enhance our understanding of pathogenesis in this important type of congenital disorder.
12p vihagrid 30-01-2023 7 3 Download
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Part 1 of ebook "Selection methods in plant breeding (2nd edition)" provide readers with content about: population genetic effects of cross-fertilization; population genetic effects of inbreeding; assortative mating and disassortative mating; population genetic effect of selection with regard to sex expression; selection with regard to a trait with qualitative variation; random variation of allele frequencies; components of the phenotypic value of traits with quantitative variation;...
234p hanlinhchi 11-11-2022 10 3 Download
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Continued part 1, part 2 of ebook "Selection methods in plant breeding (2nd edition)" provide readers with content about: applications of quantitative genetic theory in plant breeding; selection for several traits; genotype × environment interaction; selection with regard to a trait with quantitative variation; reduction of the detrimental effect of allocompetition on the efficiency of selection; optimizing the evaluation of candidates by means of plots; causes of the low efficiency of selection; the optimum generation to start selection for yield of a self-fertilizing crop;...
237p hanlinhchi 11-11-2022 10 3 Download