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Querying genes
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Genetic suppression occurs when the deleterious effects of a primary “query” mutation, such as a disease-causing mutation, are rescued by a suppressor mutation elsewhere in the genome. Methods To capture existing knowledge on suppression relationships between human genes, we examined 2,400 published papers for potential interactions identified through either genetic modification of cultured human cells or through association studies in patients.
19p
vicwell
29-02-2024
4
1
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We present SeqOthello, an ultra-fast and memory-efficient indexing structure to support arbitrary sequence query against large collections of RNA-seq experiments. It takes SeqOthello only 5 min and 19.1 GB memory to conduct a global survey of 11,658 fusion events against 10,113 TCGA Pan-Cancer RNA-seq datasets.
13p
vigalileogalilei
27-02-2022
4
1
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Efficient tools for data management and integration are essential for many aspects of high-throughput biology. In particular, annotations of genes and human genetic variants are commonly used but highly fragmented across many resources. Here, we describe MyGene.info and MyVariant.info, high-performance web services for querying gene and variant annotation information.
7p
viaristotle
29-01-2022
13
0
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The creation of arrays of yeast strains each encoding a different protein with constant tags is a powerful method for understanding how genes and their proteins control cell function. As genetic tools become more sophisticated there is a need to create custom libraries encoding proteins fused with specialised tags to query gene function.
21p
vijeeni2711
24-07-2021
9
0
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Understanding of gravity sensing and response is critical to long-term human habitation in space and can provide new advantages for terrestrial agriculture. To this end, the altered gene expression profile induced by microgravity has been repeatedly queried by microarray and RNA-seq experiments to understand gravitropism.
16p
vijichea2711
28-05-2021
12
1
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The aim of connectivity mapping is to match drugs using drug-treatment gene expression profiles from multiple cell lines. This can be viewed as an information retrieval task, with the goal of finding the most relevant profiles for a given query drug.
10p
vikentucky2711
26-11-2020
12
0
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Biological systems and processes are highly dynamic. To gain insights into their functioning time-resolved measurements are necessary. Time-resolved gene expression data captures temporal behaviour of the genes genome-wide under various biological conditions: in response to stimuli, during cell cycle, differentiation or developmental programs.
15p
vioklahoma2711
19-11-2020
11
0
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Next-generation sequencing technologies have greatly increased our ability to identify gene expression levels, including at specific developmental stages and in specific tissues. Gene expression data can help researchers understand the diverse functions of genes and gene networks, as well as help in the design of specific and efficient functional studies.
9p
vioklahoma2711
19-11-2020
6
1
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Targeted PCR amplicon sequencing (TAS) techniques provide a sensitive, scalable, and cost-effective way to query and identify closely related bacterial species and strains. Typically, this is accomplished by targeting housekeeping genes that provide resolution down to the family, genera, and sometimes species level.
13p
viconnecticut2711
28-10-2020
18
1
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ChromoWIZ: A web tool to query and visualize chromosome-anchored genes from cereal and model genomes
Over the last years reference genome sequences of several economically and scientifically important cereals and model plants became available. Despite the agricultural significance of these crops only a small number of tools exist that allow users to inspect and visualize the genomic position of genes of interest in an interactive manner.
9p
viminato2711
22-05-2020
13
1
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A member of the TaHKT2;1 multigene family was previously identified as a Na+ transporter with a possible role in root Na+ uptake. In the present study, the existing full-length cDNA of this member was used as a basis to query the International Wheat Genome Survey Sequence to identify all members of the TaHKT2;1 family.
15p
viminato2711
22-05-2020
12
0
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Translational medicine requires the full extent of patient data to be accessible so that questions spanning multiple data sources, such as those discussed above, can be asked and answered. For example, a physician in clinical practice would like to easily ask for the criteria for the diagnosis of a disease and the recommendations for perso- nalized medicines. However, TMKB has the potential to be equally relevant to scien- tists developing new pharmaceutical products.
15p
thangbienthai
17-11-2012
42
1
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources...
0p
thulanh21
15-11-2011
46
1
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Hình 2.22: Phần ảnh minh họa tổng thể kết quả BLAST Phần này cho ta thông tin tổng quát về sự bắt cặp của trình tự query với các trình tự khác trong cơ sở dữ liệu. Trình tự query là thanh đỏ có đánh số, các thanh khác là các trình tự trong cơ sở dữ liệu. Thanh nào càng gần thanh query thì sự tƣơng đồng với trình tự query càng cao, ngoài ra màu sắc cũng thể hiện độ tƣơng đồng ( màu đỏ có điểm số cao nhất, tới màu hồng,…)....
22p
zues03
19-06-2011
86
9
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