Rac inhibitors
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Even though targeted therapies are available for cancers expressing oncogenic epidermal growth receptor (EGFR) and (or) human EGFR2 (HER2), acquired or intrinsic resistance often confounds therapy success.
13p vimahuateng 26-11-2021 10 1 Download
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The Rho-like GTPase Rac regulates distinct actin cytoskeleton changes required for adhesion, migration and invasion of cells. Tiam1 specifically activates Rac, and Rac has been shown to affect several signaling pathways in a partly cell-type-specific manner. Recently, we demonstrated that Rac activation inhibits Matrigel invasion of human carcinoma cells by tran-scriptional upregulation of tissue inhibitor of metalloproteinase-1.
16p inspiron33 23-03-2013 29 2 Download