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Racemic mixtures
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For the first time, removal of oxygen atoms from allylic hydroperoxide functionality and reintroduction to the double bond was achieved using catalytic OsO4 and chiral cinchona alkaloid derivatives in an acetone–water mixture to give corresponding chiral 1/2,3-triol with an enantioselectivity up to 99% ee. The hydroperoxide group was used as both a co-oxidant and a source of hydroxyl groups.
18p
langthannam
29-12-2021
13
0
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Xanthohumol is a prenylated chalcone that exhibit antioxidant, anticancer and chemoprotective effects. Its only source in human nutrition is beer, nevertheless a large part of xanthohumol from hops is isomerized by heat to isoxanthohumol and desmethylxanthohumol, from which a racemic mixture of 6- and 8-prenylnaringenins is formed during the beer production. Xanthohumol is also converted to isoxanthohumol by digestion, leading to the formation of 8-prenylnaringenin that is being catalyzed by the enzymes of the intestinal microorganisms as well as liver enzymes.
12p
mudbound
10-12-2021
7
1
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A critical appraisal of the current strategies for the synthesis of enantiopure drugs is presented, along with a systematic background for the computational design of stereoselective porous polymers. These materials aim to achieve the enantiomeric excess of any chiral drug, avoiding the racemic separation.
6p
vijiraiya2711
27-05-2020
13
0
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The corresponding cobalt complex of the polymer brusches was used as a highly efficient recyclable catalyst for the hydrolytic kinetic resolution of racemic mixture of epichlorohydrin. The reaction was carried out under solvent-free condition at room temperature in the presence of 0.5 mol% of cobalt, with enantiomeric excess (ee) of higher than 99% and a conversion of 55% being achieved after 1.5 hours.
8p
giesumanh
07-11-2018
40
0
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Fresh root of Vietnamese carrot (Daucus carota L.) has been employed as a biocatalyst in the asymmetric reduction of prochiral ketones and the enantioselective hydrolysis of racemic esters. In the previous reaction, (S)-alcohols were formed in quantitative yield with highly enantiomeric purity (ee > 93%). However in the latter, this biocatalyst presented a poor enantioselectivity (ee < 50%). Besides, the selectively reducing capability of carrot on a conjugated aldehyde and a racemic mixture of aldehyde was also investigated.
5p
uocvong04
24-09-2015
58
2
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